Quality of life improves in children and adolescents during a community-based overweight and obesity treatment

Mollerup, Pernille Maria; Nielsen, Tenna Ruest Haarmark; Bøjsøe, Christine; Kloppenborg, Julie Tonsgaard; Baker, Jennifer L.; Holm, Jens Christian

doi:10.1007/s11136-017-1504-x

Cited by 24 publications

(19 citation statements)

References 53 publications

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“…Furthermore, the present study included a relatively large study population compared with similar previous studies in children, especially in our analyses of intervention outcome. Importantly, the children and adolescents with overweight and obesity underwent treatment using The Children’s Obesity Clinic protocol, which has, in several nonrandomized studies, shown improvement in metabolic risk variables and psychosocial well‐being, including degree of obesity in both patients and their parents , blood pressure , plasma lipid fractions , body composition , liver and muscle fat content , and quality of life .…”

Section: Discussionmentioning

confidence: 99%

Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children

Hollensted

Fogh

Schnurr

et al. 2018

Obesity

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Objective This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single‐nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents. Methods Children and adolescents with overweight or obesity (n = 920) and a population‐based control sample (n = 698) were recruited. Anthropometric and biochemical measures were obtained at baseline and in a subgroup of children and adolescents with overweight or obesity again after 6 to 24 months of lifestyle intervention (n = 754). The effects of the GRS were examined by multiple linear regressions using additive genetic models. Results At baseline, the GRS associated with BMI standard deviation score (SDS) both in children and adolescents with overweight or obesity (β = 0.033 [SE = 0.01]; P = 0.001) and in the population‐based sample (β = 0.065 [SE = 0.02]; P = 0.001). No associations were observed for cardiometabolic traits. The GRS did not influence changes in BMI SDS or cardiometabolic traits following lifestyle intervention. Conclusions A GRS for childhood BMI was associated with BMI SDS but not with other cardiometabolic traits in Danish children and adolescents. The GRS did not influence treatment response following lifestyle intervention.

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Section: Discussionmentioning

confidence: 99%

Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children

Hollensted

Fogh

Schnurr

et al. 2018

Obesity

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“…We found only 11 relevant studies for our review, although several other studies measured utility values, but were not included in our analyses because they did not report scored utility values (64)(65)(66)(67) or ascribe them to weight categories (68). Reviews of nonpreference-based studies assessing HRQoL in childhood populations suggest poorer HRQoL in obese youth (23,(69)(70)(71), with recent studies finding that interventions that reduce BMI are associated with improvements in HRQoL (72,73). Our meta-analysis results broadly support these findings; however, given this is a relatively emerging field within the literature, it is clear that more research is required to better understand potential quantitative associations useful for economic modelling.…”

Section: Discussionmentioning

confidence: 99%

Utility values for childhood obesity interventions: a systematic review and meta‐analysis of the evidence for use in economic evaluation

et al. 2018

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Rigorous estimates of preference-based utilities are important inputs into economic evaluations of childhood obesity interventions, yet no published review currently exists examining utility by weight status in paediatric populations. A comprehensive systematic literature review and meta-analysis was therefore undertaken, pooling data on preference-based health state utilities by weight status in children using a random-effects model. Tests for heterogeneity were performed, and publication bias was assessed. Of 3,434 potentially relevant studies identified, 11 met our eligibility criteria. Estimates of Cohen's d statistic suggested a small effect of weight status on preference-based utilities. Mean utility values were estimated as 0.85 (95% uncertainty interval [UI] 0.84-0.87), 0.83 (95% UI 0.81-0.85), 0.82 (95% UI 0.79-0.84) and 0.83 (95% UI 0.80-0.86) for healthy weight, overweight, obese and overweight/obese states, respectively. Meta-analysis of studies reporting utility values for both healthy weight and overweight/obese participants found a statistically significant weighted mean difference (0.015, 95% UI 0.003-0.026). A small but statistically significant difference was also estimated between healthy weight and overweight participants (0.011, 95% UI 0.004-0.018). Study findings suggest that paediatric-specific benefits of obesity interventions may not be well reflected by available utility measures, potentially underestimating cost-effectiveness if weight loss in childhood/adolescence improves health or well-being.

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“…3,4 Algunos estudios refieren que la intervención mediante la actividad física puede mejorar la calidad de vida de los niños con sobrepeso u obesidad. 5 El objetivo de este estudio fue determinar si un programa con actividad física y recomendaciones nutricionales mejora la calidad de vida relacionada con la salud (CVRS) de los niños con sobrepeso u obesidad. Se llevó a cabo un ensayo clínico aleatorizado (ECA) en la ciudad de Granada, España.…”

Section: Influencia De La Actividad Física Sobre La Calidad De Vida Dunclassified

Influencia de la actividad física sobre la calidad de vida de los niños con sobrepeso u obesidad

et al. 2019

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Quality of life improves in children and adolescents during a community-based overweight and obesity treatment

Abstract: Clinicaltrials.gov, ID-no.: NCT02013843.

Cited by 24 publications

References 53 publications

Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children

Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children

Utility values for childhood obesity interventions: a systematic review and meta‐analysis of the evidence for use in economic evaluation

Influencia de la actividad física sobre la calidad de vida de los niños con sobrepeso u obesidad

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