Quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease

Abstract

Background:Several studies have demonstrated considerable impairment of quality of life (QOL) in obstructive sleep apnea (OSA) patients, but its relation with severity of OSA is yet unclear.Study Objectives:To investigate the effects of OSA on the QOL and its association with the disease severity.Design and Setting:Observational, prospective case-control study.Materials and Methods:QOL of 69 OSA patients and 41 healthy controls were assessed using the Calgary sleep apnea quality of life index (SAQLI) on the morning following the polysomnography (PSG) study.Statistics:All statistical analyses were performed using the SPSS 17.0 (SPSS Inc., Chicago). Differences between sleep-related symptoms and SAQLI subscales scores were assessed with the Chi-square test and the Student t-test. Due to non-normal distribution, differences between SAQLI scores of controls and OSA patients were evaluated using a non-parametric Mann-Whitney test. Spearman correlation and backward multiple regression analysis were used to analyze the association between SAQLI scores and sleep indices and anthropometric variables and PSG variables.Results:Study included 69 cases (57 male and 12 females) with a mean age, weight, height, neck circumference, and body mass index 48.45 ± 10.12 years, 83.03 ± 16.48 kg, 159.75 ± 28.29 cm, 44.01 ± 3.23 cm and 30.77 ± 6.71 kg/m2. Mean apnea-hypopnea index was 26.39 ± 16.62. The median score of four SAQLI domains daily function, social interaction, emotional, symptoms and total mean SAQLI score were 3.64 (3.46-3.90), 3.77 (3.51-3.88), 3.64 (3.53-3.83), 4.80 (4.68-5.11), 4.09 (3.88-4.09),and 1.36 (1.29-1.71), 1.38 (1.24-1.62), 1.45 (1.23-1.62), 2.00 (1.78-2.26), 1.55 (1.46-1.73) for patients and controls respectively. All the individual domain scores and the mean SAQLI scores of patients were significantly higher than the controls.Conclusion:OSA causes significant impairment of QOL, but the severity of impairment is not directly proportional to the severity of OSA.

An updated review of pediatric drug‐induced sleep endoscopy

“…Those affected may suffer from daytime somnolence, academic difficulties, behavioral and neurocognitive problems, enuresis, cardiovascular complications, poor growth, and metabolic disorders. Additionally, children with OSA have been shown to have significant reductions in overall and disease‐specific quality of life . Adenotonsillar hypertrophy is recognized as the most significant contributor to OSA in otherwise healthy children.…”

Quality of Life in Obstructive Sleep Apnea-hypopnea Syndrome

“…The hypersomnia generated by the disease has an important impact on patients' lives. All studies agree that the following aspects significantly affect patients: non-restorative sleep, excessive fatigue, difficulty to stay awake, difficulties with memory and with keeping attention, falling asleep suddenly, malaise upon awakening and lack of concentration (14,16,27). This domain also seeks to identify the participation in activities and the limitation in these.…”

“…The most common manifestations of the patient with OSAHS are daytime sleepiness, nocturnal roncopathy and awakenings related to shortness of breath or respiratory effort (14), although irritability, difficulty concentrating, impaired memory, low energy for daily activities, chronic headache and depressive symptoms are also frequent (15). In addition, in patients with OSAHS there is a short-term increase in occupational and car accidents (16). All these conditions are directly related to the patient's quality of life, and not only to cardiovascular and metabolic alterations (7,17).…”

Functional capacity and quality of life between healthy subjects and patients with obstructive sleep apnea

“…Recentes estudos 3,4,5 têm avaliado e indicado as principais complicações causadas pela AOS. Assim como em nossa investigação, alguns relatos indicam um prejuízo na qualidade de vida e na capacidade funcional dessa população.…”

“…3 Esse comprometimento está relacionado com a gravidade do distúrbio do sono. 4 A capacidade funcional, que é a habilidade que o indivíduo apresenta para realizar, de forma autônoma, as atividades de vida diária (AVD'S), 5 pode estar afetada nesses pacientes. 6 De acordo com a literatura, há controvérsias quanto às limitações na capacidade funcional de pacientes com AOS.…”