Quality of life, HPV-status and phase angle predict survival in head and neck cancer patients under (chemo)radiotherapy undergoing nutritional intervention: Results from the prospective randomized HEADNUT-trial

Kutz, Laura Magdalena; Abel, Jakob; Schweizer, Diana; Tribius, Silke; Krüll, Andreas; Petersen, Cordula; Löser, Anastassia

doi:10.1016/j.radonc.2021.11.011

Cited by 14 publications

(9 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance, we observed a negative effect of long-term PEG use on survival. Since our previous works showed that malnutrition negatively impacts survival in HNC patients [ 5 , 8 ], these results are consistent [ 5 , 21 ].…”

Section: Discussionsupporting

confidence: 85%

“…Our previous works did not show any differences between the control and intervention group regarding general patient features and different oncological endpoints [ 7 , 8 ]. Accordingly, we separated our patient population into those treated with definitive versus adjuvant combined chemoradiotherapy or radiotherapy alone: In both groups (definitive vs. adjuvant setting), 21 patients (34.4% each) denied the presence of pretreatment swallowing disorders.…”

Section: Resultsmentioning

confidence: 95%

See 1 more Smart Citation

Impact of dosimetric factors on long-term percutaneous enteral gastrostomy (PEG) tube dependence in head and neck cancer patients after (chemo)radiotherapy—results from a prospective randomized trial

et al. 2022

View full text Add to dashboard Cite

Purpose/objective To analyze dose–volume histogram (DVH)-derived data on the exposure of organs at risk with impact on long-term percutaneous enteral gastrostomy (PEG) tube dependence in head and neck cancer patients at 6 and 12 months after definitive or adjuvant (chemo)radiotherapy. Materials and methods Sixty-one patients were prospectively treated with (chemo)radiotherapy. Prophylactic or reactive gastrostomy tube placement was performed in 41 (67.2%) patients. Dose–volume histogram parameters were obtained for the swallowing apparatus. Results Median follow-up time was 25 (2–34) months. Overall survival was shorter in patients with inlying PEG tubes at 6 and 12 months (log rank p = 0.038 and p = 0.017) after therapy completion. The estimated median time of tube dependency was 6 (95% confidence interval: 2–14) months. After 6 months, 46.5% of patients were tube dependent. After 12 months, this estimated proportion fell to 31.5%. For both time points, the volume to the larynx (in %) receiving at least 50 Gy (larynx V50Gy) exceeding 53% was predictive for long-term tube feeding (6 months: p = 0.041 and 12 months: p = 0.042) being an independent predictor during multivariable analysis. There was no clinical feature influencing tube dependence after 12 months. Conclusion Long-term gastrostomy dependence was found to be strongly associated with an exposure of laryngeal structures (specifically, V50Gy ≥ 53%) during radiotherapy. Consequently, the avoidance of supraglottic as well as glottic structures is warranted.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Resultsmentioning

confidence: 95%

Impact of dosimetric factors on long-term percutaneous enteral gastrostomy (PEG) tube dependence in head and neck cancer patients after (chemo)radiotherapy—results from a prospective randomized trial

et al. 2022

View full text Add to dashboard Cite

show abstract

“…After elimination of duplicates and screening of the titles and abstracts of each of the articles, 18 were selected as potentially eligible for full-text reading. Ten articles were excluded, three of them for not containing valid data [ 44 , 45 , 46 ], another three because they were poster or abstract [ 47 , 48 ], three because of a lack of a control group [ 19 , 20 , 49 , 50 ], and one for including patients without cancer [ 51 ] (provided in Supplementary Table S1 ). Finally, eight studies [ 39 , 40 , 41 , 42 , 52 , 53 , 54 , 55 ] were selected for the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Phase Angle, Handgrip Strength, and Other Indicators of Nutritional Status in Cancer Patients Undergoing Different Nutritional Strategies: A Systematic Review and Meta-Analysis

et al. 2023

View full text Add to dashboard Cite

Malnutrition in cancer patients is one of the most influential factors in the evolution and mortality of such patients. To reduce the incidence of malnutrition, it is necessary to establish a correct nutritional intervention. For this purpose, precise tools and indicators must be developed to determine the patient’s condition. The main objective of this systematic review and meta-analysis was to analyze the relationship between different nutritional strategies, phase angle (PA), and handgrip strength in patients with cancer, with the secondary objectives being the modification of other indicators of nutritional status, such as weight and body mass index (BMI). A systematic review of randomized clinical trials was carried out in March 2023 in the databases PubMed, Web of Science, Cochrane, and Scopus. As a risk-of-bias tool, RoB 2.0 was utilized. A total of 8 studies with a total of 606 participants were included in the analysis. A significant increase in PA was observed after the different nutritional strategies (SMD: 0.43; 95% CI: 0.10 to 0.77; p = 0.01; I2 = 65.63%), also detecting a significant increase in handgrip strength (SMD: 0.27, 95% CI: 0.08 to 0.47; p = 0.01; I2 = 30.70%). A significant increase in PA and handgrip were observed in cancer patients subjected to different nutritional strategies. These results suggest that these indicators could be used in the nutritional and functional assessment of the patients.

show abstract

“…Since it is well established that QoL and toxicity assessment by physicians leads to lower incidence and severity of symptoms compared to patients' reports (28), we decided to prospectively collect patientreported outcomes in addition to data retrospectively extracted from medical les. We used the multi-item multidomain EORTC QLQ-C30 and QLQ-H&N35 instruments, as they are considered reliable and valid measurement tools of QoL and are used in many international clinical trials (29)(30)(31)(32). We observed a trend for a better global QoL (77.6 vs 65.2, p = 0.07) and for a higher role functioning score (91.4 vs 80.3, p = 0.06) according to the QLQ-C30 questionnaire after eRT ± CT.…”

Section: Discussionmentioning

confidence: 99%

Exclusive Radio±chemoTherapy versus upfront Surgery in the treatment of HPV-related localized or locally ADvanced Oropharyngeal squamous cell Carcinoma (RT-SHADOC): a tricentric study of efficacy, tolerance and quality of life

Baude,

Guigou,

Thibouw

et al. 2023

Preprint

View full text Add to dashboard Cite

Background The treatment of stage I-III HPV + oropharyngeal squamous cell carcinoma (HPV-OPSCC) is based on either surgery ± adjuvant therapy or exclusive radio ± chemotherapy. We sought to compare these two therapeutic strategies in terms of efficacy, tolerance and quality of life (QoL).Methods Patients treated for stage I-III HPV-OPSCC from 2010 to 2021in 3 academic centers were included and sorted according to the treatment strategy: surgery or exclusive radio ± chemotherapy. Efficacy and tolerance were retrospectively assessed, and QoL was prospectively evaluated using QoL assessment instruments.Results Eighty-three patients were included, 21 underwent surgery and 62 definitive radio-±chemotherapy. 2-year progression-free survival (PFS) and overall survival (OS) were respectively 80% and 86% in the surgical group and 92% and 95% in the non-surgical group, with no significant difference. At the end of treatment, 64.5% of patients presented a grade III symptom, without significant difference between the two groups. No patient had late grade III toxicity at 24 months. Forty-five patients (11 in the surgical group, 34 in the nonsurgical group) participated in the prospective quality-of-life analysis. Patients reported significantly more fatigue and loss of appetite after surgery, whereas patients in the radio ± chemotherapy group described significantly more salivary and oral problems and difficulty swallowing. The global quality of life score tended to be better in the radio ± chemotherapy group (EORTC QLQ-C30 77.6 vs 65.2, p = 0.07).Conclusion No significant difference in terms of efficacy, physician-reported toxicity and patient-reported quality of life was found between surgery and radio ± chemotherapy in the treatment of stage I-III HPV-OPSCC.

show abstract

Quality of life, HPV-status and phase angle predict survival in head and neck cancer patients under (chemo)radiotherapy undergoing nutritional intervention: Results from the prospective randomized HEADNUT-trial

Cited by 14 publications

References 45 publications

Impact of dosimetric factors on long-term percutaneous enteral gastrostomy (PEG) tube dependence in head and neck cancer patients after (chemo)radiotherapy—results from a prospective randomized trial

Impact of dosimetric factors on long-term percutaneous enteral gastrostomy (PEG) tube dependence in head and neck cancer patients after (chemo)radiotherapy—results from a prospective randomized trial

Phase Angle, Handgrip Strength, and Other Indicators of Nutritional Status in Cancer Patients Undergoing Different Nutritional Strategies: A Systematic Review and Meta-Analysis

Exclusive Radio±chemoTherapy versus upfront Surgery in the treatment of HPV-related localized or locally ADvanced Oropharyngeal squamous cell Carcinoma (RT-SHADOC): a tricentric study of efficacy, tolerance and quality of life

Contact Info

Product

Resources

About