“…The primary outcome in the included studies was mortality/survival (n = 9, 50%), 24,[26][27][28]32,33,35,36,40 time to hospital (n = 5) 29,31,37-39 and quality of life (n = 3). 25,30,34 One included randomized controlled trial reported mortality as a secondary outcome, whereas Glasgow Outcome Score was the primary outcome. 23 The presented studies were mainly from Europe (n = 15) and the median study duration time was 22 months [13.25-40] ( Table 1).…”