Quality of Life following Radical Surgical Treatment of Gastric Carcinoma

Thybusch-Bernhardt, A.; Schmidt, Christian; Küchler, Thomas; Schmid, Andreas; Henne‐Bruns, Doris; Kremer, Bernd

doi:10.1007/pl00012339

Cited by 50 publications

(24 citation statements)

References 14 publications

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“…In the present study, there were no differences in quality of life relating to the extent of the lymphadenectomy, in agreement with the results of other studies 14,15 . Thybusch-Bernhardt et al 15 analysed a series of 152 patients with gastric cancer, 81 per cent of whom had undergone a D2 lymphadenectomy and 19 per cent an extended gastrectomy.…”

Section: Discussionsupporting

confidence: 94%

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Impact of surgical procedure for gastric cancer on quality of life

Liaño

Martínez

Ciga

et al. 2003

British Journal of Surgery

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Background:The aim was to assess quality of life in a group of patients who had a curative resection for gastric cancer. Methods:The European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire with a gastric cancer-specific module was used in patients who had undergone R0 gastrectomy between 1992 and 1999, and who had no disease at the last check-up. A response was obtained from 54 patients, 36 men and 18 women, of mean age 67 years. Of these, 24 patients had total gastrectomy and 26 D2 lymphadenectomy.Results: Significant differences were found only in the social domain of quality of life in patients aged over 70 years (P = 0·036); there was no impact of operation type on overall quality of life.Conclusion: The quality of life of patients undergoing curative surgery for gastric cancer, regardless of age, was not significantly influenced by the type of gastrectomy, or whether lymphadenectomy was performed.

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Section: Discussionsupporting

confidence: 94%

“…Thybusch-Bernhardt et al 15 analysed a series of 152 patients with gastric cancer, 81 per cent of whom had undergone a D2 lymphadenectomy and 19 per cent an extended gastrectomy. They concluded that neither operative procedure adversely affected the patient's state of health.…”

Section: Discussionmentioning

confidence: 99%

Impact of surgical procedure for gastric cancer on quality of life

Liaño

Martínez

Ciga

et al. 2003

British Journal of Surgery

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“…All patients in our study had undergone radical surgery before they commenced adjuvant treatment. Several research groups, using a variety of instruments [Short Form (SF-36) Health Survey, D15, Spitzer Quality of Life Index, eortc qlq-C30 and -STO22], have reported a reduction in qol in similar populations [18][19][20][21] .…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Impact on Quality of Life of Chemoradiation in Gastric Cancer

et al. 2010

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ObjectiveOur phase i study prospectively evaluated quality of life (qol) in patients undergoing adjuvant chemoradiation for gastric adenocarcinoma. MethodsThirty-three patients receiving radiotherapy (45 Gy in 25 fractions), together with 12 weeks of infusional 5-fluorouacil and escalating doses of cisplatin every 2 weeks, completed the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 at five time points: baseline, completion of radiation, 4 weeks after completion of radiation, 6-12 months after completion of chemoradiation, and 2-3 years after completion of chemoradiation. ResultsMean age of the patients was 56 years (range: 31-77 years); 55% of the patients were male. Median followup was 2.7 years (range: 0.3-5 years). The 3-year overall survival was 83%. Five patients experienced dose-limiting toxicity (dlt). Median scores on global qol and on the social, role, emotional, nausea and vomiting, and fatigue scales showed clinically and statistically significant worsening at completion of radiation. Statistical but not clinical worsening was found for the physical and appetite scales. By 6-12 months, no subscale showed a difference, on average, from the baseline score. However, up to 45% of the patients remained below baseline on at least 1 subscale. Patients with dlt had worse scores on the emotional and the nausea and vomiting scales. Scores for global qol and for nausea and vomiting were significantly associated with chemotherapy dose. ConclusionsDuring chemoradiation, qol is impaired. Although most scores return to baseline, recovery may take 6-12 months, and subscale scores remain below baseline in a significant proportion of patients.

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“…Cross-sectional studies (Koster et al, 1987;Kusche et al, 1987;Buhl et al, 1990;Korenaga et al, 1992;Jentschura et al, 1997;Wu et al, 1997a;Zieren et al, 1998;Svedlund et al, 1999;Thybush-Bernhardt et al, 1999) of QOL after gastric cancer surgery provided important background for design of this study, delineating a number of specific hypotheses and research questions related to surgery and survivorship. This report examines QOL of gastric cancer patients receiving either D1 or D3 surgery.…”

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confidence: 99%

Quality of life after curative gastrectomy for gastric cancer in a randomised controlled trial

Chiou

et al. 2008

Br J Cancer

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Quality of life (QOL) was studied in gastric cancer patients treated on a randomised, controlled trial comparing D1 (level 1) with D3 (levels 1, 2 and 3) lymphadenectomy. A total of 221 patients were randomly assigned to D1 (n ¼ 110) and D3 (n ¼ 111) surgery. Quality-of-life assessments included functional outcomes (a 14-item survey about treatment-specific symptoms) and health perception (Spitzer QOL Index) was performed before and after surgery at disease-free status. Patients suffered from irrelative events such as loss of partners was excluded thereafter. Main analyses were done by intention-to-treat. Thus, 214 D1 (106/ 110 ¼ 96.4%) and D3 (108/111 ¼ 97.3%) R0 patients were assessed. Longitudinal analysis showed that functional outcomes decreased at 6 months after surgery and increased over time thereafter, while health perceptions increased over time in general. On the basis of linear mixed model analyses, patients having total gastrectomy, advanced cancer and hemipancreaticosplenectomy, but not complications had poorer QOL than those without. D1 and D3 patients showed no significant difference in QOL. The results suggest that changes of QOL were largely due to scope of gastric resection, disease status and distal pancreaticosplenectomy, rather than the extent of lymph node dissection. This indicates that nodal dissection can be performed for a potentially curable gastric cancer.

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Quality of Life following Radical Surgical Treatment of Gastric Carcinoma

Cited by 50 publications

References 14 publications

Impact of surgical procedure for gastric cancer on quality of life

Impact of surgical procedure for gastric cancer on quality of life

Evaluating the Impact on Quality of Life of Chemoradiation in Gastric Cancer

Quality of life after curative gastrectomy for gastric cancer in a randomised controlled trial

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