Quality of life during the first year after partial laryngectomy: Longitudinal study

Clasen, Daniel; Keszte, Judith; Dietz, Andreas; Oeken, Jens; Meister, E. F.; Guntinas‐Lichius, Orlando; Pabst, Friedemann; Büntzel, Jens; Jenzewski, E.-M.; Schnittger, Susanne; Meyer, Alexandra

doi:10.1002/hed.25095

Cited by 18 publications

(15 citation statements)

References 34 publications

(49 reference statements)

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“…Assessing the quality of life of patients with head and neck cancer is relevant for understanding the impact of the disease and its treatment on patients and patients' daily life 15 . The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ‐C30) is widely used to assess HRQOL in a patient with cancer.…”

Section: Introductionmentioning

confidence: 99%

Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer

Musoro

Coens

Schnittger³

et al. 2020

Head & Neck

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Background: We aimed to estimate minimally important difference (MID) for interpreting group-level change over time for European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scores in head and neck cancer. Methods: Data were derived retrospectively from two published EORTC trials. Clinical anchors were selected using correlation strength and clinical plausibility of the given anchor/QLQ-C30 scale pair. MIDs for within-group and

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Section: Introductionmentioning

confidence: 99%

Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer

Musoro

Coens

Schnittger³

et al. 2020

Head & Neck

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“…предложили свою интерпретацию для опросника EORTC QLQ-C30, изучая КЖ только у пациенток с раком молочной железы, проходящих полихимиотерапию [16], данный подход получил распространение. По крайней мере в одном исследовании авторы применили такой подход к изучению КЖ пациентов, перенесших резекцию гортани [17]. И снова клиническая интерпретация результатов внесла свои коррективы.…”

Section: Discussionunclassified

Dynamics of quality of life of head and neck cancer patients after treatment. Clinical significance

Карпенко

Сибгатуллин

Бойко

et al. 2019

Opuholi golovy i šei

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The study objective is to evaluate the quality of life as one of the main parameters that determines the effectiveness of treatment of patients with head and neck squamous cell carcinoma.Materials and methods. Thirty-three stage III—IV oral cancer patients aged between 39 and 70 years were asked to fill EORTC QLQ-C30 (European Organisation for Research and Treatment of Cancer quality of life questionnaire core 30-questions) and QLQ-H&N35 (head and neck cancer-specific module) before and 12—18 months after completion of the treatment that consisted of surgery followed by radiation with or without chemotherapy. Surgery included neck dissection with removal of the primary tumor via transoral (n = 5) or combined (n = 28) approach. Reconstruction was performed by primary closure (n = 5), with pedicled (n = 8) or free (n = 20) flaps.Results. According to EORTC QLQ-C30 questionnaire only positive shifts turned out to be statistically significant: general health, emotional function, pain, insomnia and diarrhea. Site-specific EORTC QLQ-H&N35 questionnaire revealed several positive (pain in the head and neck, feeling ill, use of painkillers and weight gain) and negative (public eating, problems with taste and smell, sticky saliva and dry mouth) changes. Applying algorithms for determining clinical significance changed the number and value of several scales and domains. Changes in general health, emotional function, pain, insomnia, pain in the head and neck, taste and smell disorders, mouth opening, sticky saliva, dry mouth, painkillers and weight gain were found to have some clinical relevance. Moreover, for one of them (mouth opening) statistical significance was not reached.Conclusions. Further research of clinical significance of changes and differences in scales and domains that determine and affect quality of life are needed. They will allow to understand more fully problems that every patient with oral cavity cancer tries to cope with.

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“…High‐risk patients must be adequately instructed that OPLS could heavily affect their swallowing, respiratory, and phonatory functions . Quality of life could be then severely impaired for a long period of time and whether OPLS reduces it to a lesser extent compared to total laryngectomy is not clear …”

Section: Discussionmentioning

confidence: 99%

“…30 Quality of life could be then severely impaired for a long period of time and whether OPLS reduces it to a lesser extent compared to total laryngectomy is not clear. [38][39][40] The other two models (Figures 2 and 3) are complication-specific and they can be even more useful for the head and neck surgeon. In the nomogram for airway complications, we have specifically investigated the incidence of postoperative pneumonia, emphysema, dysphagia or development of a laryngocutaneous fistula (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Nomograms for prediction of postoperative complications in open partial laryngeal surgery

Gallo

Locatello

Larotonda

et al. 2018

Journal of Surgical Oncology

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Background and Objectives Postoperative morbidity after open partial laryngeal surgery (OPLS) may be serious, leading to a prolonged length of hospital stay and increasing costs. We sought to define the predictive factors of complications and to develop nomograms for patients eligible for OPLS based on clinical and surgical data. Methods We critically reviewed 535 patients with laryngeal carcinoma who underwent OPLS at our Institution from 1982 to 2007. We have identified patients affected by postoperative local, airway, dysphagia, bleeding, surgical site infection, dehiscence of pexy, emphysema, and laryngocutaneous fistula complications. We have analyzed them according to age, smoking, alcohol, tumor site, clinical T and N classification, type of OPLS and neck dissection, previous treatments. Prognostic factors were considered in a multivariate logistic regression model with backward stepwise elimination and selected to construct and design nomograms for overall and specific complications. The performance was assessed using the c‐index, receiver operating characteristic, and calibration curves. Results Age, clinical T classification, type of OPLS, and alcohol were related to overall (35%) and airway complications. Nomograms were built for overall, dysphagia, and airway complications. Conclusions We have developed nomograms that can identify high‐risk patients undergoing OPLS and that can help to prevent severe complications and to tailor surgical planning.

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Quality of life during the first year after partial laryngectomy: Longitudinal study

Abstract: The discovered limitations of QOL should be observed more closely during follow-up treatment, and patients should be informed about these potential effects before partial laryngectomy.

Cited by 18 publications

References 34 publications

Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer

Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer

Dynamics of quality of life of head and neck cancer patients after treatment. Clinical significance

Nomograms for prediction of postoperative complications in open partial laryngeal surgery

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