Quality of life domains relevant to people living with HIV and AIDS who are on antiretroviral therapy in Swaziland

Ntshakala, Theresa Thembi; Mavundla, Thandisizwe Redford; Dolamo, Bethabile Lovely

doi:10.4102/curationis.v35i1.87

Cited by 9 publications

(12 citation statements)

References 10 publications

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“…Consequently, to increase the length and quality of survival of PLWHA who are on ART, it is essential that an evaluation of their QoL becomes more important than quantity of life. ART may indeed prolong life but may only do so at considerable cost to the QoL of PLWHA [17]. There is a geographical discrepancy in HIV/AIDS economic evaluation research [18].…”

Section: Introductionmentioning

confidence: 99%

Health related quality of life of people receiving highly active antiretroviral therapy in Southwest Ethiopia

Desta¹,

Biru

Kefale

2020

PLoS ONE

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Background Highly Active Antiretroviral Therapy (HAART) is a standard of HIV management to suppress viral load and delay progression to AIDS. However, questions have been raised about the use of antiretroviral therapy and how it affects quality of life (QoL) of people living with HIV/ AIDS (PLWHA). The study hence aimed to assess the QoL of PLWHA who were taking HAART at Mizan-Tepi University Teaching Hospital (MTUTH) and identify factors associated with QoL. Methods A cross sectional study was conducted among PLWHA receiving HAART at MTUTH from March 04-April 1, 2018. Patients were recruited consecutively and interviewed with structured questionnaire. A data abstraction tool was used to extract data from patient medical records. Quality of life was assessed using the World Health Organization Quality of Life HIV-BREF (WHOQOL-HIV-BREF) standard tool. Data was entered to Epi-Info version 3.5.3 and analyzed using SPSS version 22 for windows. A multivariable logistic regression analysis was fitted to identify factors associated with QoL. A statistical significance was established at a p value <0.05. Results A total of 240 participants with the mean age of 35.11 (SD = 9.08) years were included in the study. This study found that 57.1% of the patients had high global score of QoL. Patients with normal current health (AOR = 3.38, 95% CI = 1.56-7.31)) and having family support (AOR = 3.12, 95% CI = 1.51-6.46) were positively associated with high global score of QoL, while patients with low HAART adherence (AOR = 0.40, 95%, CI = 0.19-0.86) were negatively associated with high global score of QoL.

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Section: Introductionmentioning

confidence: 99%

Health related quality of life of people receiving highly active antiretroviral therapy in Southwest Ethiopia

Desta¹,

Biru

Kefale

2020

PLoS ONE

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“…ART defaulters in this study might have discontinued their ART when they became more focused on spirituality and religion as coping mechanisms, but this could not be confirmed nor denied based on the available information. Ntshakala 17 studied the QoL of ART patients in Swaziland and found that spirituality conflicted with ART adherence. Other researchers reported similar associations between spirituality and HRQoL.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported that PLWHA who experienced challenges in coping with ART had poorer ART adherence levels and poorer HRQoL mean scores compared to PLWHA without such challenges. 17 , 19 …”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life of antiretroviral treatment defaulters in Botswana

Ndubuka

Lim

Wal

et al. 2016

South. Afr. j. HIV med.

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BackgroundAntiretroviral therapy (ART) improves patients’ health-related quality of life (HRQoL). Defaulting from ART has detrimental consequences, including the development of viral resistance, treatment failure and increased risks of disease progression. Little is known about the quality of life of ART defaulters and reasons for discontinuing their ART.ObjectivesThis study sought to measure the HRQoL of ART patients in Botswana who were on ART for up to 5 years but had discontinued treatment for at least 3 months, and to identify factors associated with ART defaulting.MethodWe conducted a cross-sectional study with 104 eligible respondents in four ART clinics in south eastern Botswana. We assessed respondents’ HRQoL using the World Health Organization Quality of Life Questionnaire for HIV short form. Clinical information was obtained from respondents’ medical records. Data were analysed using SAS version 9.2.ResultsReasons for discontinuing ART were inaccessible clinics (22.4%), feeling better (21.4%), running out of pills (11.2%), depression (8.2%), lack of care and/or support (8.2%), failure to understand instructions (7.7%), medications’ side effects (6.1%) and alcohol abuse (3.1%). In multivariate analyses, respondents aged 36–45 years had a 0.03 lower independence HRQoL score compared to those aged 35 and younger (β = -0.03; 95% confidence interval: -1.72, -1.66). Despite defaulting from their ART, respondents’ calculated HRQoL scores were moderate.ConclusionThis study highlights the need to enhance ART adherence in order to improve the HRQoL of people living with HIV and/or AIDS.

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“…HAART may lengthen life, but at a significant cost to the HRQoL of HIV-infected people. 13 The more HAART improves the QoL of patients, the more difficult it becomes to maintain frequent contact with healthcare providers, leading to monthly appointments to obtain HAART being missed. 14 On the other hand, the assessment of HRQoL in these patients has become important, as their well-being may be affected not only by treatment failure but also by other treatmentrelated toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the QoL of people taking HAART has also been measured by the presence or absence of side effects of HAART. 13 In Ethiopia, HIV/AIDS has been recognized not only as a health problem, but also as a development challenge. Despite the efforts to contain the spread of the infection and prolong the lives of infected people by increasing access to antiretroviral drugs and improving clinical care, there has been less focus on patients' QoL and associated factors in the country.…”

Section: Introductionmentioning

confidence: 99%

<p>Assessment of Health-Related Quality of Life and Associated Factors Among HIV/AIDS Patients on Highly Active Antiretroviral Therapy (HAART) at Ambo General Hospital, West Shewa, Ethiopia</p>

Dinsa¹,

Atomsa²,

Taye³

2020

HIV

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Background: Determining the degree of health-related quality of life (HRQoL) and associated factors in human immunodeficiency virus (HIV)-positive people is of great importance. Objective: The aim of this study was to assess the HRQoL and associated factors among HIV-infected patients who were on highly active antiretroviral therapy (HAART) at Ambo General Hospital. Methods: A study with a cross-sectional design was conducted on 296 HIV-infected patients who were on HAART at Ambo General Hospital from February 20 to May 20, 2019. Patients were recruited by a random sampling technique and a P-value <0.05 was set as statistically significant. Th main outcome measure was HRQoL. Results: The majority of study participants were female (56.8%). More than half (53%) of the participants had low overall HRQoL. Those who were married and who earned <1500 ETB were less likely to experience low overall HRQoL than single people (AOR: 4.41, P=0.024) and those who earned more (AOR: 4.27, P=0.000), respectively. Those with current illness and who had no HIV-positive family members were more likely to experience lower overall quality of life than those with no current illness (AOR: 32.29, P=0.000) and with one HIV-positive family member (AOR: 4.03, P=0.003), respectively. Those with recent WHO clinical stage I were less likely to experience a lower overall quality of life than those with stage II (AOR: 0.07, P=0.000). Conclusion: Current illness, recent WHO stage and having no HIV-positive family members were found to be strongly associated with lower quality of life in HIV-positive patients on antiretroviral therapy.

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Quality of life domains relevant to people living with HIV and AIDS who are on antiretroviral therapy in Swaziland

Cited by 9 publications

References 10 publications

Health related quality of life of people receiving highly active antiretroviral therapy in Southwest Ethiopia

Health related quality of life of people receiving highly active antiretroviral therapy in Southwest Ethiopia

Health-related quality of life of antiretroviral treatment defaulters in Botswana

<p>Assessment of Health-Related Quality of Life and Associated Factors Among HIV/AIDS Patients on Highly Active Antiretroviral Therapy (HAART) at Ambo General Hospital, West Shewa, Ethiopia</p>

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