Quality of life changes during adjuvant chemotherapy in patients with colon cancer

Lee, Seo Hee; Lee, Taek-Gu; Baek, Moo Jun; Kim, Jang Jin; Park, Sung Su; Lee, Sang-Jeon

doi:10.14216/kjco.16010

Cited by 1 publication

(1 citation statement)

References 26 publications

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“…To identify papers containing data on colorectal cancer as well as other types of cancer, a separate search was performed, and 23 authors were separately contacted for data on colorectal cancer patients. As one author sent the original data, one additional study [13] was included; one study [14] was newly included by manual search, resulting in a total of 11 studies. [4,5,13-21] Among them, eight studies pertained to the treatment of colon cancer and rectal cancer patients with chemotherapy, and the other three pertained to the treatment of rectal cancer patients with neoadjuvant chemotherapy.…”

Section: The Main Author (Syh) Made Decisions On Initial Article Inclmentioning

confidence: 99%

Neurocognitive Effects of Chemotherapy for Colorectal Cancer: A Systematic Review and a Meta-Analysis of 11 Studies

Hwang

Kim

et al. 2021

Cancer Res Treat

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Chemotherapy-related cognitive impairment (CRCI) is a controversial concept not much explored on colorectal cancer patients. Materials and Methods We identified eleven prospective studies: eight studies on 696 colorectal cancer patients who received chemotherapy and three studies on 346 rectal cancer patients who received neoadjuvant chemoradiotherapy. Standardized mean differences (SMDs) of neuropsychological test results and the cognitive quality-of-life scale were calculated using random effect models. A meta-regression was conducted to investigate the association between mean study population age and effect sizes. Results The association between chemotherapy and cognitive impairment was not clear in colorectal cancer patients (SMD, 0.003; 95% confidence interval,-0.080 to 0.086). However, a metaregression showed that older patients are more vulnerable to CRCI than younger patients (β=-0.016, p < 0.001). Conclusion Chemotherapy has an overall positive negligible effect size on the cognitive function of colorectal patients. Age is a significant moderator of CRCI.

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Section: The Main Author (Syh) Made Decisions On Initial Article Inclmentioning

confidence: 99%

Neurocognitive Effects of Chemotherapy for Colorectal Cancer: A Systematic Review and a Meta-Analysis of 11 Studies

Hwang

Kim

et al. 2021

Cancer Res Treat

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Quality of life changes during adjuvant chemotherapy in patients with colon cancer

Cited by 1 publication

References 26 publications

Neurocognitive Effects of Chemotherapy for Colorectal Cancer: A Systematic Review and a Meta-Analysis of 11 Studies

Neurocognitive Effects of Chemotherapy for Colorectal Cancer: A Systematic Review and a Meta-Analysis of 11 Studies

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