Quality-of-Life Changes Among Patients With Obsessive-Compulsive Disorder in a Partial Hospitalization Program

Bystritsky, Alexander; Saxena, Sanjaya; Maidment, Karron M.; Vapnik, Tanya; Tarlow, Gerald; Rosen, Richard

doi:10.1176/ps.50.3.412

Cited by 55 publications

(36 citation statements)

References 8 publications

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“…However, some studies report that the decrease in productivity and quality of life of severely ill and/or treatment-resistant anxiety patients was comparable to those of schizophrenics. 10,11 Anxiety Disorders Association of America estimates the costs to be over 42 billion dollars per year comparable to those of stroke and cardiovascular disorders. 12 …”

Section: Introductionmentioning

confidence: 99%

Treatment-resistant anxiety disorders

2006

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Several epidemiological studies confirmed that Anxiety Disorders as a group are the most prevalent psychiatric conditions in the United States. The importance of these conditions is underlined by the fact that they cause significant disability, poor quality of life, alcohol and drug abuse. Anxiety disorders are treatable conditions and respond to the front-line interventions such as serotonin reuptake inhibitors and cognitive behavioral therapy. However, only about 60% of patients respond to those treatments to any significant degree. Many still have residual symptoms or stay treatment refractory. The group of anxiety patients that is resistant to the treatment has been shown to have very poor quality of life and have highest rate of suicidal attempts than any other disorders. Many biological, treatment specific and social factors are affecting treatment resistance. In this paper, we are attempting to review reasons for the treatment resistance. In addition, we would like to review current strategies that could be helpful in reducing treatment resistance and aiding people chronically suffering from these severe and disabling conditions.

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Section: Introductionmentioning

confidence: 99%

Treatment-resistant anxiety disorders

2006

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“…The extant research suggests that significant but small improvements in QOL occur after cognitive-behavioral therapy or pharmacological treatment for OCD [e.g., Stewart et al, 2005;Tenney et al, 2003]. Overall improvements in QOL typically are unrelated or are related weakly to symptom reduction [e.g., Bystritsky et al, 1999]. Bystritsky et al [2001] compared psychosocial deficits and QOL impairments in patients with OCD to patients with schizophrenia before and after their respective treatments.…”

Section: Introductionmentioning

confidence: 99%

Quality of life in obsessive-compulsive disorder: an evaluation of impairment and a preliminary analysis of the ameliorating effects of treatment

et al. 2008

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Despite the substantial impairments in life functioning associated with obsessive-compulsive disorder (OCD), treatment outcome evaluations have focused almost exclusively on symptom reduction, a focus that may be too narrow to determine whether clinically significant change has occurred. Quality of life (QOL) impairment was evaluated in a clinical OCD sample (N=188) using a multidimensional life satisfaction measure. Relationships between treatment response and QOL change also were evaluated with a subsample of participants (n=120). Congruent with previous studies of OCD, substantial pretreatment QOL impairment was found across all life domains. Distinct treatment change subgroups were identified: a group reporting strong symptom reduction and very good QOL gains, a second group with significant symptom reduction but less robust QOL improvements, and a third group with limited symptom gains and QOL decreases. Implications for understanding OCD-related impairment and the clinical significance of treatment outcomes are discussed.

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“…Such insight helps the therapist create a basis to construct an adequate treatment strategy for the patient. Some studies reported that QoL improves over the course of psychotherapy and psychopharmacological treatment in OCD [9][10][11][12][13] . However, there is some evidence that QoL increases independent of symptom improvement.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Obsessive-Compulsive Disorder: The Different Impact of Obsessions and Compulsions

et al. 2007

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Background: Patients with obsessive-compulsive disorder (OCD) are troubled by repeated obsessions and/or compulsions, which seem senseless and frequently repugnant. Objective: The study examines the differential impact of obsessions and compulsions on the quality of life (QoL) of patients with OCD. Methods: Seventy-five patients (43 females, 32 males) between 21 and 62 years old with OCD (ICD 10 F42.0–F42.2) were recruited from the outpatient clinic for anxiety disorders at the Department of Psychiatry of the University of Leipzig. The severity of OCD symptoms was assessed by the Yale Brown Obsessive-Compulsive Scale (a standardized, clinician-administered scale), and depressiveness was assessed with the Beck Depression Inventory (a self-report instrument). QoL was assessed by means of the WHOQOL-BREF, a self-administered questionnaire developed by WHO. Results: Compulsions reduced patients’ QoL in the WHOQOL-BREF domains ‘physical well-being’, ‘psychological well-being’ and ‘environment’, whereas obsessions did not have any impact on QoL ratings. Depressive symptoms were a strong predictor of poor QoL in OCD patients. Conclusions: In order to judge the QoL of OCD patients, obsessions and compulsions have to be considered differently. Diagnosing and treating depressive symptoms is important for improving the QoL in OCD.

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Quality-of-Life Changes Among Patients With Obsessive-Compulsive Disorder in a Partial Hospitalization Program

Cited by 55 publications

References 8 publications

Treatment-resistant anxiety disorders

Treatment-resistant anxiety disorders

Quality of life in obsessive-compulsive disorder: an evaluation of impairment and a preliminary analysis of the ameliorating effects of treatment

Quality of Life in Obsessive-Compulsive Disorder: The Different Impact of Obsessions and Compulsions

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