Quality of life by proxy and mortality in institutionalized older adults with dementia

González-Vélez, Abel E; Forjaz, Maria João; Giráldez‐García, Carolina; Martín-García, Salomé; Martinez‐Martín, Pablo

doi:10.1111/ggi.12225

Cited by 16 publications

(12 citation statements)

References 33 publications

(71 reference statements)

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“…Alzheimer’s disease (AD) was the most included type of dementia, and it was the sole subtype evaluated in over a third of the studies ( n = 11) [ 20 , 25 , 27 , 28 , 32 , 39 , 43 – 47 ] ; four studies considered AD in combination with dementia with Lewy Bodies (DLB) [ 21 , 31 ], vascular dementia (VD) [ 34 ] or mixed [ 30 ]. Seven of the studies considered any type of dementia [ 19 , 24 , 33 , 35 , 37 , 38 , 40 ], and eight studies did not specify the type of dementia under investigation [ 22 , 23 , 26 , 29 , 36 , 41 , 42 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

Convergent validity of EQ-5D with core outcomes in dementia: a systematic review

Hussain

Keetharuth

Rowen

et al. 2022

Health Qual Life Outcomes

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Objectives To explore through a systematic review, the convergent validity of EQ-5D (EQ-5D-3L and EQ-5D-5L (total score and dimensions)) with core outcomes in dementia and investigate how this may be impacted by rater-type; with the aim of informing researchers when choosing measures to use in dementia trials. Methods To identify articles relevant to the convergent validity of EQ-5D with core dementia outcomes, three databases were electronically searched to September 2022. Studies were considered eligible for inclusion within the review if they included individual level data from people with dementia of any type, collected self and/or proxy reported EQ-5D and collected at least one core dementia outcome measure. Relevant data such as study sample size, stage of dementia and administration of EQ-5D was extracted, and a narrative synthesis was adopted. Results The search strategy retrieved 271 unique records, of which 30 met the inclusion criteria for the review. Twelve different core outcome measures were used to capture dementia outcomes: cognition, function, and behaviour/mood across the studies. Most studies used EQ-5D-3L (n = 27). Evidence related to the relationship between EQ-5D and measures of function and behaviour/mood was the most robust, with unanimous directions of associations, and more statistically significant findings. EQ-5D dimensions exhibited associations with corresponding clinical outcomes, whereby relationships were stronger with proxy-EQ-5D (than self-report). Conclusion Measuring health-rated quality of life in dementia populations is a complex issue, particularly when considering balancing the challenges associated with both self and proxy report. Published evidence indicates that EQ-5D shows evidence of convergent validity with the key dementia outcomes, therefore capturing these relevant dementia outcomes. The degree of associations with clinical measures was stronger when considering proxy-reported EQ-5D and differed by EQ-5D dimension type. This review has revealed that, despite the limited targeted psychometric evidence pool and reliance on clinical and observational studies, EQ-5D exhibits convergent validity with other dementia outcome measures.

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Section: Resultsmentioning

confidence: 99%

Convergent validity of EQ-5D with core outcomes in dementia: a systematic review

Hussain

Keetharuth

Rowen

et al. 2022

Health Qual Life Outcomes

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“…Using proxies to determine the HRQoL has been done before, e.g., relatives, friends, or professional caregivers were questioned if patients themselves were unable to answer the questionnaire due to illness or insufficient cognitive abilities (e.g., critically ill patients [ 55 ], patients with dementia [ 56 ], or young children [ 57 , 58 ]). While the agreement between patients and proxies was relatively good in some studies (e.g., [ 55 ]), there is evidence that proxies tend to report a lower quality of life than the patients themselves [ 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Disease profile and health-related quality of life (HRQoL) using the EuroQol (EQ-5D + C) questionnaire for chronic metallic mercury vapor intoxication

Steckling

Plaß

Blüml

et al. 2015

Health Qual Life Outcomes

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BackgroundToxic mercury is still being used today for example by workers mining gold, resulting in diverse health symptoms in users and individuals in proximity. A considerable burden of disease (BoD) can be assumed, while previous analyses were limited by data scarcity. Besides limited epidemiological data, neither data about the health-related quality of life (HRQoL) nor about the disease severity (disability weight, DW) is available. The aim of the project was to develop disease profiles of chronic metallic mercury vapor intoxication (CMMVI) by including the HRQoL to improve the data basis for BoD analyses of gold miners exposed to mercury.MethodsDisease profiles comprising the disease label [a], differentiation into disease stages [b], description of the cause of exposure [c], a list of common symptoms [d], and an assessment of the HRQoL [e] were developed using expert elicitation and literature search. The HRQoL was assessed by experts using the five EuroQol dimensions accompanied by the cognition add-on questionnaire (EQ-5D + C).ResultsThe ten sources used for the analyses (interview transcript, presentation, and eight literature reviews) identified more than 250 terms describing 85 distinguishable health effects of CMMVI. The analysis revealed 29 common symptoms that were frequently mentioned. Moderate and severe CMMVI cases differ regarding their symptoms and/or symptom severity and HRQoL, resulting in the EQ-5D + C-3L codes 121222 and 233333, respectively.ConclusionsThe profiles should be used to facilitate the ascertainment of CMMVI cases, to compare the HRQoL with other diseases, to derive DWs for improving BoD estimates, and to foster discussions about how to reduce the associated burden.Electronic supplementary materialThe online version of this article (doi:10.1186/s12955-015-0388-0) contains supplementary material, which is available to authorized users.

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“…Mild cognitive impairment (MCI), an intermediate state from normal aging to dementia,1 has gradually aroused global health professionals’ interests 2. McDaniel advocated for the first time in 1971 that cognitive dysfunction may correlate with renal failure 3.…”

Section: Introductionmentioning

confidence: 99%

Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study

Pei¹,

Lai²,

He³

et al. 2018

CIA

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IntroductionFew studies focused on mild cognitive impairment (MCI) in maintenance hemodialysis (MHD) patients. This study was conducted to survey the prevalence, the potent risk factors of MCI in MHD patients, and further observe the progress of MCI in a period of 6 months.MethodologyMini-Mental State Examination, and Montreal Cognitive Assessment were used to assess cognitive condition. MHD patients were enrolled from The First Affiliated Hospital of Nanjing Medical University, who had a stable hemodialysis history for more than 3 months.ResultsSixty-four MHD patients and 54 general subjects were finally included. The average age of both groups was more than 60 years. The prevalence of MCI in the MHD group was significantly higher than that in general population (60.9% vs 29.6%, P<0.05). Spearman correlation analysis indicated that MCI was related to age, comorbidities, education years, uric acid, serum albumin, and blood pressure. The prevalence and severity of MCI in the MHD group remained unchanged during the 6 months (prevalence: 59.5%–66.6%, MoCA scores: 22.9–22.5).ConclusionMHD patients sustain a fairly high prevalence of MCI. Multiple risk factors influence the incidence and progression of MCI in MHD patients. More attention should be paid to this special population.

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Quality of life by proxy and mortality in institutionalized older adults with dementia

Cited by 16 publications

References 33 publications

Convergent validity of EQ-5D with core outcomes in dementia: a systematic review

Convergent validity of EQ-5D with core outcomes in dementia: a systematic review

Disease profile and health-related quality of life (HRQoL) using the EuroQol (EQ-5D + C) questionnaire for chronic metallic mercury vapor intoxication

Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study

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