Quality of life as an outcome variable and a risk factor for total mortality and cardiovascular disease

Tibblin, Gösta; Svärdsudd, Kurt; Welin, Lennart; Erikson, Henry; Larsson, Bo

doi:10.1097/00004872-199306003-00015

Cited by 35 publications

(38 citation statements)

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“…As noted earlier, HRQOL predicts mortality in disease-specific patients; however, evidence-based results are needed to determine whether the generic self-reported HRQOL is independently associated with mortality among the general and recent activity limitation) were significant predictors of short-term and long-term hospitalization and mortality in Cox regression models controlling for demographic factors and co-morbidity [32]. A previous study in Sweden, the Go¨teborg Quality of Life Assessment [10], was constructed in 1973 from the response of men that were 50 years old at the time of the initial survey (1963) and re-evaluated 10 years later. The quality of life assessment consisted of evaluations of subjective well-being, health, and welfare.…”

Section: Discussionmentioning

confidence: 97%

“…Most previous HRQOL studies focused on causespecific measures, and there is evidence that HRQOL measures predict cause-specific mortality, such as mortality due to heart or cardiovascular disease [9][10][11][12], hemodialysis [13][14], asthma [15], and chronic obstructive pulmonary disease [16][17]. Few studies, however, have explored whether generic self-reported HRQOL measures are independently associated with mortality in community-dwelling older persons.…”

Section: Introductionmentioning

confidence: 99%

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Health-related quality of life as a predictor of mortality among community-dwelling older persons

Yang²,

et al. 2007

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Health-related quality of life (HRQOL) measures predict cause-specific mortality, but few studies have explored whether generic self-reported HRQOL measures are independently associated with mortality in community-dwelling older persons. We postulated that a general measure of HRQOL, the short form 36-item questionnaire (SF-36), would be independently predictive of mortality among community-dwelling older persons. To evaluate this hypothesis, we followed a fixed cohort of 4,424 community-dwelling older persons recruited from a 2000 population-based survey in Taiwan until 2003 and investigated whether HRQOL was predictive of 3-year mortality, even after adjusting for traditional clinical risk variables. The data were collected via a door-to-door survey, and interviewers collected information on the subjects' demographics, medical history, utilization of health services, functional ability, falls, and self-reported physical and mental symptoms. Of the 6053 eligible subjects, 4,424 residents agreed to participate in the baseline survey and were contacted in 2003. During the 3-year period, the 3-year cumulative mortality rate for the study population was 5%. Mortality was significantly higher among males (5.57% vs. 4.27%, p = 0.049), and cumulative mortality increased with age (chi (2)-test for trend; chi (2) = 7.734, p = 0.001). For all scales except bodily pain, there was a significant relationship between a 10-point lower baseline score and mortality. Our primary multivariate risk model, which included two summary measures of HRQOL and significant clinical variables, demonstrated that a 10-point decrease in either the baseline Physical Component Summary (PCS) score or the baseline Mental Component Summary (MCS) score was associated with higher mortality (PCS: RR: 1.60, 95% CI: 1.39-1.83; p < 0.001; MCS: RR: 1.16, 95% CI: 1.01-1.34; p = 0.036). The findings suggested that low baseline PCS and MCS scores were important independent risk factors for 3-year mortality among community-dwelling older persons, even after adjusting for other risk factors.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Health-related quality of life as a predictor of mortality among community-dwelling older persons

Yang²,

et al. 2007

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“…Thus, impaired HRQOL has been incriminated for cardiovascular disorders as well as increased incidence of death and hospitalization [30,31,32,33]. It has been shown that lower scores in the three major components of HRQOL are strongly associated with a higher risk of death and hospitalization, independent of demographic and comorbid factors in hemodialysis patients [13,34].…”

Section: Discussionmentioning

confidence: 99%

Adaptation and Validation of the Kidney Disease Quality of Life-Short Form Questionnaire in the Greek Language

Malindretos

Sarafidis

Spaia³

et al. 2009

Am J Nephrol

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Aim: The aim of this study was to examine the validity, reproducibility and internal consistency of a Greek translation of the Kidney Disease Quality of Life-Short Form (KDQOL-SF) questionnaire. Methods: The KDQOL-SF questionnaire was translated from English to Greek and was administered in 240 randomly selected patients undergoing hemodialysis in six Renal Units in Greece. The instrument’s validity was tested by examining the association between patient’s KDQOL-SF scores and comorbidity assessed with the Index of Coexistent Disease. Reproducibility was examined by readministering the questionnaire in 50 randomly selected patients within 1 month. Internal consistency was assessed by estimating Cronbach’s alpha coefficient. Results: Patients were divided into two groups according to the severity of comorbidity assessed with the Index of Coexistent Disease. Those with less comorbid conditions had significantly higher scores in most components of the KDQOL-SF questionnaire, confirming its validity. The correlation coefficients between the two administrations of the instrument ranged from 0.88 to 0.98 for each of the main components, which was above the desired level of 0.85. Cronbach’s alpha coefficient ranged from 0.91 to 0.92 for the various components, values well above the minimum desired 0.70 level. Conclusions: The present study shows that the Greek version of the KDQOL-SF questionnaire has high validity, reproducibility and internal consistency. Production of validated translations of the KDQOL-SF questionnaire in various languages will help promote health-related quality of life of end-stage renal disease patients all over the world.

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“…To optimize dialysis therapy, however, the health-related quality of life (HRQOL) of hemodialysis patients also needs to be improved. To improve the HRQOL of these patients, it is important to identify factors that contribute to their poor quality of life [7,15,31,33,35].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with health-related quality of life among hemodialysis patients in the DOPPS

et al. 2007

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Quality of life as an outcome variable and a risk factor for total mortality and cardiovascular disease

Cited by 35 publications

References 0 publications

Health-related quality of life as a predictor of mortality among community-dwelling older persons

Health-related quality of life as a predictor of mortality among community-dwelling older persons

Adaptation and Validation of the Kidney Disease Quality of Life-Short Form Questionnaire in the Greek Language

Factors associated with health-related quality of life among hemodialysis patients in the DOPPS

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