Quality of life, anxiety and depression patient‐reported outcome measures in testicular cancer: A systematic review

Abstract

Objectives Several patient‐reported outcome measures (PROMs) are available for the assessment of quality of life (QoL), anxiety and depression for testicular cancer (TCa); however, these PROMs have uncertain validation of their psychometric properties for TCa‐only cohorts. This systematic review aims to critically analyse and evaluate the psychometric properties of these QoL, anxiety and depression PROMs. Methods PubMed, EMBASE and PsycInfo were searched by two independent reviewers from inception to August 2020. Evaluative studies that assessed measurement properties of PROM(s) tools used for measuring QoL, anxiety and depression in TCa patients were included. The COnsensus‐based Standards for the selection of health status Measurement Instruments (COSMIN) updated criteria for good measurement properties were used in the evaluation of PROM psychometric quality. This systematic review was registered on the PROSPERO database (CRD42020160232). Results Of 4,305 abstracts screened, a final eight full‐text articles were included in this review. Five general and two TCa‐specific PROMs were identified (depression, n = 1; anxiety and depression, n = 2; QoL, n = 4). All studies were incomplete in the validation of nine measurement properties and the modal methodological quality was ‘indeterminate’. The European Organisation for Research and Treatment of Cancer Quality ‐Testicular Cancer 26 questionnaire and CAYA‐T had the highest psychometric validation with three out of nine measurement properties being ‘sufficient’. Conclusion This systematic review identifies a paucity of PROM‐validation studies assessing anxiety, depression and QoL in TCa‐only cohorts. We recommend further comprehensive and standardised psychometric validation studies of QoL, anxiety and depression PROMs in TCa‐only study populations.

Patient Reported Outcome Measures for Salivary Function: A Systematic Review

“…We utilized the COSMIN standards, a series of reporting guidelines for studies of PROM measurement properties, which have been widely used to assess the quality of other disease-specific PROMs. [45][46][47][48] Overall, we found significant variability in the developmental quality and measurement properties of the 16 identified PROMs. Of the instruments evaluated in this review, the Xerostomia Inventory represented the most rigorously developed PROM for xerostomia evaluation and met criteria for adequacy in nearly all (6/7) domains except content validity.…”

“…In this review, we assessed the quality of currently available PROMs for salivary dysfunction, including hyposalivation, obstructed salivation, and hypersalivation symptoms. We utilized the COSMIN standards, a series of reporting guidelines for studies of PROM measurement properties, which have been widely used to assess the quality of other disease‐specific PROMs 45–48 . Overall, we found significant variability in the developmental quality and measurement properties of the 16 identified PROMs.…”

Quality of life assessment in testicular non-seminomatous germ cell tumour survivors

“…Socioeconomic factors [32] and nancial toxicity [7] have been shown to interact and in uence QoL in complex ways. Anxiety and depression, both more common in GCT [5], may impact QoL [13,33].…”

Testicular Cancer Treatments and Sexuality: A Narrative Review

“…Despite the high survival rate and the high rate of response to treatments [15], many TC patients experience a broad set of undesired social, psychological, and sexual side effects due to the treatments [16][17][18][19][20]. In particular, as part of the male reproductive system, the testes play a functional role in spermatogenesis and in the formation of testosterone by assisting in androgen production [21][22][23], and so, this can be impaired.…”