Quality of Life, Anxiety, and Depression in Patients With Early-Stage Mycosis Fungoides and the Effect of Oral Psoralen Plus UV-A (PUVA) Photochemotherapy on it

Graier, Thomas; Fink‐Puches, Regina; Porkert, Stephanie; Lang, Roland; Pöchlauer, Sophie; Ratzinger, Gudrun; Tanew, Adrian; Selhofer, Sylvia; Sator, Paul‐Gunther; Hofer, Angelika; Gruber‐Wackernagel, Alexandra; Legat, Franz J.; Vieyra-Garcia, Pablo A.; Quehenberger, Franz; Wolf, Peter

doi:10.3389/fmed.2020.00330

Cited by 8 publications

(5 citation statements)

References 59 publications

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“…It is encouraging to discover that they acknowledge the emotional influence of MF. Interestingly, previous studies have reported low anxiety levels in patients (5,18,19). However, concerns were raised regarding the adequacy of the scales used to assess anxiety in these patients, and it is possible that patients with more advanced stages indeed are more anxious.…”

Section: Discussionmentioning

confidence: 99%

Illness Perception Regarding Early-stage Mycosis Fungoides among Dermatologists: A Multi-centre Cross-sectional Study

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Goldzweig

Bratt³

et al. 2022

Acta Derm Venereol

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Early-stage mycosis fungoides is a rare cutaneous T-cell lymphoma with a good prognosis. Data regarding patients’ illness perception of mycosis fungoides are accumulating. However, investigating the dermatologists’ viewpoint is also essential, as it shapes the therapeutic relationship and doctor–patient communication. The aim of this study was to investigate the aspects of dermatologists’ illness perception towards early-stage mycosis fungoides and the way they present it to patients. Twenty-five dermatology residents and 55 attending physicians from all Israeli dermatology departments and the community completed the study questionnaires online. Dermatologists viewed mycosis fungoides as a chronic disease, causing a moderate emotional burden. In contrast to previously published data regarding patients’ illness perception, dermatologists demonstrated dominancy in the notion that patients were able to control their disease. Most dermatologists thought that patients perceived mycosis fungoides as an indolent lymphoma that causes anxiety. Dermatologists used a high diversity of themes when presenting mycosis fungoides to patients. The differences between the residents’ and attending physicians’ perceptions were minimal. Dermatologists have a kaleidoscope of views regarding the way they perceive mycosis fungoides, the way they think patients perceive it, and the way they communicate with patients. Maintaining patient-centred communication enables dermatologists to identify these gaps and view mycosis fungoides from their patients’ perspective.

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Section: Discussionmentioning

confidence: 99%

Illness Perception Regarding Early-stage Mycosis Fungoides among Dermatologists: A Multi-centre Cross-sectional Study

Segal

Goldzweig

Bratt³

et al. 2022

Acta Derm Venereol

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“…The lack of any demographic or obvious clinical differences between the objective responders and the nonresponders contributes to the strength of the data. Only one other study to date has evaluated psychological distress in relation to treatment in this population, 7 assessing the impact of PUVA. Our study adds evidence to support the benefit of other treatment modalities on mental health in this population as well as the impact of treatment on worrying.…”

Section: Discussionmentioning

confidence: 99%

“… 6 Psoralen plus ultraviolet A photochemotherapy (PUVA) has recently been shown to improve health-related quality of life and psychological well-being in patients with early-stage MF. 7 However, only limited general psychological distress questionnaires have been used for CTCL, while no worry-specific instruments have been used.…”

Section: Introductionmentioning

confidence: 99%

Psychological Distress and Treatment Outcome in Patients With Early-Stage Mycosis Fungoides

Henderson Berg,

Popradi,

Roberge

et al. 2024

J Cutan Med Surg

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Background: Skin diseases have been shown to worsen psychological distress, which, in turn, may be detrimental to treatment outcomes. Both the impact of psychological distress on response to treatment in mycosis fungoides (MF) and the effect of treatments on psychological well-being are unclear. Objectives: To evaluate (1) the association between pretreatment psychological morbidity and treatment outcome in early-stage MF and (2) the impact of response to treatment on psychological well-being. Methods: This was a prospective cohort study of patients with early-stage MF who started a new stage-directed treatment for their disease. The response was determined using the modified severity-weighted assessment tool, and psychological distress was assessed using the 12-item General Health Questionnaire (GHQ-12) and Penn State Worry Questionnaire (PSWQ). Participants were followed for 1 year. Results: In all, 24 consecutive patients were recruited. Objective response rate was 71% (17/24), consistent with existing literature. Prior to treatment, 9 patients (38%) had clinically significant psychological distress on the GHQ-12, while 8 (33%) demonstrated high-level worry on the PSWQ. Of these patients, 6 had pathologic scores on both instruments. Patients with significantly less baseline anxiety/depression on the GHQ-12 responded better to treatment than patients with higher levels ( P = .004). In addition, responders’ mean GHQ-12 scores decreased by 39% and their PSWQ scores by 17%, whereas nonresponders’ GHQ-12 scores increased by 93% ( P = .042) and their PSWQ scores by 11% ( P = .019). Conclusions: These findings suggest that (1) baseline psychological distress is associated with worse outcomes in patients with early-stage MF and that (2) effective treatment improves psychological morbidity.

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“…scalp, nails, palms/soles or inverse/genital areas), arthritis, depression or systemic treatment. Adjusting the data used for the PFIS statistical analysis (as was done in a previous study for DLQI) by excluding the items with the answer “does not apply to me” (as was previously done for DLQI) 23 did not significantly change the study results (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Psoriasis and its impact on close relatives and partners of patients – A cross‐sectional questionnaire study

Grossschaedl,

Weger,

Graier

et al. 2024

Skin Health and Disease

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BackgroundLittle is known about the exact impact of psoriasis on the disease burden of close relatives and partners of those affected by the disease.ObjectivesThe aim of this single‐centre cross‐sectional study was to evaluate the quality of life in psoriasis patients and the impact of disease on partners and close relatives.Methods250 plaque‐type psoriasis patients (58.4% males and 41.6% females) with mostly treatment‐controlled disease (mean PASI of 1.7 and Dermatology Life Quality Index (DLQI) of 4.1) were recruited from the Psoriasis Registry Austria (PsoRA) and their close relatives and partners were invited to participate in the study. Patient Family Impact Score (PFIS) was calculated from the FamilyPso questionnaire data to establish categories of disease burden in close relatives and partners.ResultsValid FamilyPso questionnaires were returned from 153 (61.2%) close relatives and partners. Correlation analysis revealed a significant association between PASI and DLQI (r = 0.512, p < 0.001), PASI and PFIS (r = 0.228, p = 0.006), and DLQI and PFIS (r = 0.210, p = 0.014). An at least small or larger impairment of life quality (DLQI ≥ 2) was observed in 46.7% of psoriasis patients, despite treatment. A small or larger disease burden was detected in nearly 78.7% of the male and 77.3% of the female relatives and partners quantified with categorized PFIS.ConclusionsThe study revealed a significant impact of patients' psoriasis on the disease burden of close relatives and partners, depending on the severity of PASI and extent of quality of life disruption in patients. The gender of the relatives and partners had no impact on the PFIS.

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Quality of Life, Anxiety, and Depression in Patients With Early-Stage Mycosis Fungoides and the Effect of Oral Psoralen Plus UV-A (PUVA) Photochemotherapy on it

Cited by 8 publications

References 59 publications

Illness Perception Regarding Early-stage Mycosis Fungoides among Dermatologists: A Multi-centre Cross-sectional Study

Illness Perception Regarding Early-stage Mycosis Fungoides among Dermatologists: A Multi-centre Cross-sectional Study

Psychological Distress and Treatment Outcome in Patients With Early-Stage Mycosis Fungoides

Psoriasis and its impact on close relatives and partners of patients – A cross‐sectional questionnaire study

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