Quality of Life and Symptom Burden among Long-Term Lung Cancer Survivors

Yang, Ping; Cheville, Andrea L.; Wampfler, Jason A.; Garces, Yolanda I.; Jatoi, Aminah; Clark, Matthew M.; Cassivi, Stephen D.; Midthun, David E.; Marks, Randolph S.; Aubry, Marie Christine; Okuno, Scott H.; Williams, Brent A.; Nichols, Francis C.; Trastek, Victor F.; Sugimura, Hiroshi; Sarna, Linda; Allen, Mark S.; Deschamps, Claude; Sloan, Jeff A.

doi:10.1097/jto.0b013e3182397b3e

Cited by 161 publications

(140 citation statements)

References 35 publications

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“…Even long-term survivors still experienced clinically significant dyspnea, fatigue and pain [11], with a poorer HRQoL as a result [6,11]. Additionally, previous findings from studies conducted in North America and Europe have shown that factors such as old age, male, low income, extent of resection, squamous cell carcinoma and adjuvant therapy, and high fatigue and pain scores are associated with poorer HRQoL [11][12][13].…”

Section: Introductionmentioning

confidence: 96%

Supportive care needs and health-related quality of life among Chinese lung cancer survivors

Chan¹,

Choi²,

Chan³

et al. 2012

ALC

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Purpose: The purpose of this study was to explore the supportive care needs and health-related quality of life (HRQoL) of lung cancer survivors, and to identify the association between patient characteristics, HRQoL and supportive care needs. Method: This was a sub-study of a larger scale survey of cancer survivors' supportive care needs. A total of 48 lung cancer survivors were recruited from a regional teaching hospital, and a three-part structured questionnaire was used to collect 1) socio-demographic and clinical characteristics, 2) supportive care needs and 3) health-related quality of life data. Results: The three most commonly reported unmet needs were all in the health-system information domain: 1) being informed about your results as soon as possible (58%), 2) being informed about cancer which is under control or diminishing (50%), and 3) being informed about things you can do to help yourself get well (46%). The second most common unmet need domain was access to healthcare and ancillary support services. The survivors generally reported satisfactory HRQoL. However, household income and unmet physical and psychological needs were independently associated with HRQoL among these survivors. Conclusion: The high unmet needs in the health-system information area call for a review of the content and amount of information provided to lung cancer survivors. In addition, more attention should be given to lung cancer survivors with low incomes but high physical and psychological unmet needs, who require appropriate follow-up and long-term care of a physical, social and psychological kind.

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Section: Introductionmentioning

confidence: 96%

Supportive care needs and health-related quality of life among Chinese lung cancer survivors

Chan¹,

Choi²,

Chan³

et al. 2012

ALC

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“…Leo et al [15] konnten zeigen, dass bei etwa 25% der Patienten, vor allem bei älteren Patienten sowie Patienten mit bereits präoperativ eingeschränkter Lebensqualität, im Zeitraum von 6 Monaten nach Pneumonektomie eine Minderung der Lebensqualität angegeben wurde [30]. Die Lebensqualität nach Lungenresektion wird somit zunehmend zu einem wichtigen Aspekt und sollte daher präoperativ mit dem Patienten besprochen werden.…”

Section: Lebensqualität Nach Pneumonektomieunclassified

“…Als signifikanten Risikofaktor für eine reduzierte Lebensqualität im postoperativen Verlauf konnte in unterschiedlichen Studien das Patientenalter über 70 Jahre identifiziert werden [7,15,19]. Die Patienten berichten über Schmerzen, Müdigkeit, Dyspnoe, Husten und verminderten Appetit [30]. Yang et al [30] berichten, dass ausgedehnte Resektionen des Lungenparenchym über die Lobektomie hinaus, die Lebensqualität und Beschwerdesymptomatik negativ beeinflussen.…”

Section: Lebensqualität Nach Pneumonektomieunclassified

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Folgen der Pneumonektomie in der Früh- und Spätphase

Hatz

Klotz

2013

Chirurg

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Pneumonectomy can represent the appropriate surgical treatment option in advanced or centrally localized non-small cell lung cancer (NSCLC). A satisfactory oncologic tumor surgery can be reached in these cases although pneumonectomy is associated with a significantly higher mortality and morbidity than less extensive resection of the lung parenchyma.The aim of this article is a systematic review and the presentation of possible postoperative consequences of pneumonectomy in the early and late phases, which depend not only on the underlying disease but are also primarily affected by the state and function of the remaining contralateral lung parenchyma. Cardiopulmonary complications, especially pneumonia, pulmonary embolism, cardiac arrhythmia or myocardial infarction lead to increased 30-day mortality in the early postoperative period. Moreover, advanced ages over 70 years can be identified as a significant risk factor for poor quality of life after pneumonectomy.

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“…Samples were obtained at the time of tumor diagnosis. Formalin-fixed paraffin-embedded samples (if available after diagnosis), slides (for diagnosis) or both were stored at the Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and patients were followed up for 10 years after diagnosis (18). Among the 571 patients selected, 278 (48.7%) exhibited adenocarcinoma, 76 (13.4%) carcinoid tumors, 52 (9.1%) squamous carcinoma, 34 (6.0%) SCLC and 131 (22.9%) possessed other or unspecified cell type tumors.…”

Section: Case Series Reportmentioning

confidence: 99%

Metformin use and young age lung cancer: A case series report

et al. 2016

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Abstract. Metformin, a widely-prescribed antihyperglycemic drug for the treatment of diabetes mellitus type 2 (DM-II), has been demonstrated to be antineoplastic in vivo and in vitro. However, various preclinical and epidemiological studies investigating the effects of metformin on lung cancer have obtained inconclusive results. The aim of the present study was to retrospectively investigate the effects of metformin, for the treatment of diabetes mellitus type 2 (DM-II), on the onset of lung cancer. In the present study, the pathological features of ten consecutive young age lung cancer cases, aged between 15 and 45 years old at the time of diagnosis and exhibiting existing primary DM, were investigated using the Mayo Clinic Lung Cancer Cohort database. Amongst this cohort, there were 2 cases of DM type 1 (DM-I) and 8 cases of DM-II. Of these patients, two exhibiting adenocarcinoma and DM-II had not been administered metformin; however, 1 patient exhibiting lymphoma and 4 patients with pulmonary neuroendocrine tumors (NETs) had been administered metformin at least 12 months prior to lung cancer diagnosis. The remaining 3 patients exhibiting NETs and DM-II had been treated with insulin therapy. The present study hypothesized that the high proportion of NETs observed in the cases of metformin-treated DM-II was unlikely to be a random event. It was suggested that metformin treatment was not effective in the prevention of pulmonary NETs, and that metformin may instead induce the occurrence of NETs via as yet unknown signaling pathways. The present hypothesis may potentially serve as a novel indicator for the requirement to monitor young patients with diabetes, who are being treated with metformin, for the occurrence of pulmonary NETs.

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Quality of Life and Symptom Burden among Long-Term Lung Cancer Survivors

Cited by 161 publications

References 35 publications

Supportive care needs and health-related quality of life among Chinese lung cancer survivors

Supportive care needs and health-related quality of life among Chinese lung cancer survivors

Folgen der Pneumonektomie in der Früh- und Spätphase

Metformin use and young age lung cancer: A case series report

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