Quality of Life and Sexual Function Benefits of Long-Term Testosterone Treatment: Longitudinal Results From the Registry of Hypogonadism in Men (RHYME)

Rosen, Raymond C.; Wu, Frederick C. W.; Behre, Hermann M.; Porst, Hartmut; Meuleman, E.J.H.; Maggi, Mario; Romero-Otero, Javier; Martínez-Salamanca, Juan Ignacio; Jones, T. Hugh; Debruyne, F.M.J.; Kurth, K. H.; Hackett, Geoff; Quinton, Richard; Ströberg, Peter; Reisman, Yacov; Pescatori, Edoardo S.; Morales, Antonio Martín; Bassas, Lluís; Cruz, Natalio; Cunningham, Glenn R.; Wheaton, Olivia

doi:10.1016/j.jsxm.2017.07.004

Cited by 31 publications

(22 citation statements)

References 29 publications

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“…Studies have shown that testosterone replacement therapy (TRT) can offer a wide range of benefits that extend beyond sexual health for men with hypogonadism. These include improved: mood; cognition; muscle mass; bone density; red blood cell production, and metabolic control . There is also increasing research demonstrating that all‐cause mortality in men who have a low testosterone level is higher than in those with a normal testosterone level …”

Section: Epidemiology and Diagnosis Of Tdsmentioning

confidence: 99%

NHS discrimination of testosterone deficiency syndrome

Cervoni¹

2020

Trends Urol & Men's Health

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Section: Epidemiology and Diagnosis Of Tdsmentioning

confidence: 99%

NHS discrimination of testosterone deficiency syndrome

Cervoni¹

2020

Trends Urol & Men's Health

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“…In the case of sexual problems due to hypogonadism and erectile dysfunction, testosterone and phosphodiesterase type 5 inhibitor (PDE5 inhibitors) can improve sexual function [28,[33][34][35]. For treatment or prevention of postmenopausal vaginal atrophy, various options are available, such as hormonal replacement therapy (systemic and topical) [36].…”

Section: Treatment Strategies For Sexual Dysfunctionmentioning

confidence: 99%

Recommended patient information sheet on the impact of haematopoietic cell transplantation on sexual functioning and sexuality

Eeltink¹,

Incrocci²,

Leeuw³

2019

ecancer

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Sexual concerns are common after haematopoietic cell transplantation (HCT). Exposure to total body irradiation (TBI), alkylating agent and graft versus host disease (GvHD) can all affect sexual function, leading to problems in sexual desire, arousal and the orgasm phase of the sexual response cycle. In high-risk haematological malignancies, such as acute leukaemia and myelodysplastic syndromes, HCT often offers the highest chance for long-term survival. In addition, these haematological diseases and HCT can have an impact on body image, self-esteem, (sexual) relationship and psychosocial factors, all of which are able to affect sexuality and sexual function. Five years post HCT, 80% of the female survivors and 46% of the male survivors report sexual dysfunction.It has been shown that these patients cope better after having discussed sexual health. While healthcare providers (HCPs) have the responsibility to address sexual issues, it has been demonstrated that 48%-82% HCT recipients reported not having discussed sexual issues with their HCPs and that only one-third of the HCPs routinely discussed sexual issues with their patients. HCPs describe a lack of knowledge and being uncomfortable with the topic as the most important reasons for not addressing sexual functioning. Even so, it would help >90% HCPs if the patient initiated discussing sexual issues. However, to empower patients addressing sexual issues, adequate comprehensive patient information is needed. In an effort to better meet the patients' need, a patient information sheet: 'Information for patients undergoing Hematopoietic Cell Transplantation: the impact of the disease and treatment on sexual function and sexuality', has been created.In this review, we describe what is known about the impact of HCT on sexual function and briefly the management of sexual problems.

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“…5. Sexuality: Lower T is associated with lower sexuality, variously measured (Yeap et al 2012;Corona et al 2017;Rizk et al 2017;Rosen et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Enzyme Immunoassays May Be Inaccurate: Familiar Correlates of Male Testosterone (T) Replicate in Britons when T is Measured by Mass Spectrometry but Do Not Replicate in Americans When T is Measured by Enzyme Immunoassay

Mazur

Clifton

2018

Preprint

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Several correlations have been reported between men's testosterone (T) and other characteristics, e.g., T declines during the day, declines with obesity, and declines with advancing age. We asked if these relationships hold in older men when T is assayed from saliva.Here seven familiar correlations are tested among older American men, their salivary T measured by enzyme immunoassay (EIA). Some correlations can also be tested among older British men, their salivary T assayed by liquid chromatography-tandem mass spectroscopy (LC-MS/MS), a technique noted for its specificity. Most of our attempts at replication failed in the American data but succeeded in the British data. We conclude that failure to replicate in Americans is likely due to inaccuracy of EIA values for T, and that most T correlations hold true in older men when salivary T is accurately measured by LC-MS/MS. 3 central regulator of crucial body functions, these alterations can be translated in significant clinical sequelae" (Diamanti-Kandarakis et al. 2017).Here we ask if seven previously-reported correlates of T, usually measured from serum, are still seen in older men when T is assayed from saliva. We tested these correlations in two large datasets, one American and one British. American data were collected by the National Social Life, Health & Aging Project (NSHAP), a two-wave panel (years 2006 and 2011) of older Americans ranging in age from 57 to 85 at Wave 1. T was measured in each wave by enzyme immunoassay (EIA) of saliva samples collected at the time of interview.British data were collected in a single wave of the National Survey of Sexual Attitudes and Lifestyles: 2010-2012 (Natsal-3), which assayed salivary T by liquid chromatography-tandem mass spectroscopy (LC-MS/MS), a technique noted for its specificity. Natsal-3 did not include all the variables used from NSHAP so not as many correlations could be tested.Several validation studies show salivary T to be correlated with "free" T in serum, i.e., with that small portion of total T not bound to protein and thus physiologically active (Shirtcliff et al. 2002;Keevil et al. 2014;Fiers et al. 2014). Biobehavioral researchers increasingly collect saliva rather than blood since saliva is cheaper and easier. Among several assay techniques, EIA has become a workhorse of behavioral studies because it is quick, convenient, inexpensive, and does not require radioactive material. Recently, however, Welker et al. (2016) presented results that question the accuracy of EIA for measuring salivary T. PREVIOUSLY REPORTED CORRELATES OF MALE TWithout presenting a full literature review, we note correlations previously reported, which can be tested on one or both of our datasets. For example, it is now well established 4 that in men, T has a diurnal rhythm, that low T is associated with obesity, and that T usually declines as men age. These head the list of propositions tested here in older men, which also contains other T correlations reported less frequently or consistently:1. Diurnal: Male T has a diurnal rh...

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Quality of Life and Sexual Function Benefits of Long-Term Testosterone Treatment: Longitudinal Results From the Registry of Hypogonadism in Men (RHYME)

Cited by 31 publications

References 29 publications

NHS discrimination of testosterone deficiency syndrome

NHS discrimination of testosterone deficiency syndrome

Recommended patient information sheet on the impact of haematopoietic cell transplantation on sexual functioning and sexuality

Enzyme Immunoassays May Be Inaccurate: Familiar Correlates of Male Testosterone (T) Replicate in Britons when T is Measured by Mass Spectrometry but Do Not Replicate in Americans When T is Measured by Enzyme Immunoassay

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