Quality of life and sexual problems in disease‐free survivors of cervical cancer compared with the general population

Abstract

Several MR methods have been proposed over the last decade to obtain quantitative estimates of the tissue blood oxygen saturation (StO2) using a quantification of the blood oxygen level dependent effect. These approaches are all based on mathematical models describing the time evolution of the MR signal in biological tissues in the presence of magnetic field inhomogeneities. Although the experimental results are very encouraging, possible biases induced by the model assumptions have not been extensively studied. In this study, a numerical approach was used to examine the influence on T2*, blood volume fraction, and StO2 estimates of possible confounding factors such as water diffusion, intravascular signal, and presence of arterial blood in the voxel. To evaluate the impact of the vessel geometry, straight cylinders and realistic data from two‐photon microscopy for microvascular geometry were compared. Our results indicate that the models are sufficiently realistic, based on a good correlation between ground truth and MR estimates of StO2. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.

Quality of Life by Stage of Cervical Cancer among Malaysian Patients

“…For global health status or overall QOL, patients with cancer stage I, II and III have higher QOL compared to stage IV. These findings were similar with other studies (Park, 2007;Yao Xie, 2013). According to their studies, stage of cancer had a direct significant negative effect on QOL.…”

“…Besides that, some studies (Ferrandina et al, 2012;Mantegna et al, 2013) also suggested that QOL and sexual activity differ in early stage and late-stage cervical cancer. However, a study on QOL among the cervical cancer survivors found that the stage of cancer with adjustment of treatment does not give clinical meaningful differences in EORTC QLQ-30 or CX-24 subscales (Park et al, 2007). This finding concurred other studies which showed no significant association between stage of cancer and QOL (Greimer, 2007;Mirabeau-Beale et al, 2009).…”

Prevalence of Urogynaecological Symptoms in Survivors of Cervical Cancer in a Tertiary Care Gynaecologic Oncology Clinic of a Developing Country

“…Cystitis is seen usually as radiation doses approach 3000 cGy to the bladder. [1][2][3][4][5][6] This presents as accompanied by suprapubic tenderness, dysuria, urinary frequency and urgency Incontinence. As doses to the bladder approach more than 6000 cGy, acute hemorrhagic cystitis, chronic cystitis, fibrosis with decreased bladder capacity, and fistula formation may ensue.…”

“…As doses to the bladder approach more than 6000 cGy, acute hemorrhagic cystitis, chronic cystitis, fibrosis with decreased bladder capacity, and fistula formation may ensue. [1][2][3][4][5][6] The treatment of urinary incontinence in patients with prior radiation exposure and history of radical hysterectomy is particularly complicated especially for continuous incontinence of extraurethral origin viz fistula as surgical treatments can be compromised by the poor vascular supply to the tissues after radiation therapy. [4][5][6][7] Chemotherapy has widespread effects on various systems and specifically to lower urinary tract, can be a cause of haemorrhagic cystitis.…”

“…[1][2][3][4][5][6] The treatment of urinary incontinence in patients with prior radiation exposure and history of radical hysterectomy is particularly complicated especially for continuous incontinence of extraurethral origin viz fistula as surgical treatments can be compromised by the poor vascular supply to the tissues after radiation therapy. [4][5][6][7] Chemotherapy has widespread effects on various systems and specifically to lower urinary tract, can be a cause of haemorrhagic cystitis. [2][3][4] While assessing the need for specialist urogynaecological input in our patients, we noticed that contemporary literature available on morbidity burden of urinary symptoms is restricted only to very few specific conditions/complications.…”