Quality of life and sense of coherence in young people and adults with uncomplicated epilepsy: A longitudinal study

Persenius, Mona; Rystedt, Ingrid; Wilde‐Larsson, Bodil; Bååth, Carina

doi:10.1016/j.yebeh.2015.04.002

Cited by 11 publications

(3 citation statements)

References 23 publications

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“…For example, O’Donohoe (1983) suggested that restrictions imposed on a child with epilepsy are typically in proportion to the severity of their epilepsy, and children with intractable or refractory epilepsy, whose seizures are not well controlled by treatment, are typically considered to have a more severe form of epilepsy [23]. For some children with epilepsy, repetitive seizures may negatively impact their quality of life, education employment and they may be at elevated risk of early mortality [24]. Epilepsy is a common neurological disorder, that affects 1–3% of the general population and ~0.6% of the pediatric population [25].…”

Section: Epilepsymentioning

confidence: 99%

Genetics and Extracellular Vesicles of Pediatrics Sleep Disordered Breathing and Epilepsy

Sanz-Rubio

2019

IJMS

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Sleep remains one of the least understood phenomena in biology, and sleep disturbances are one of the most common behavioral problems in childhood. The etiology of sleep disorders is complex and involves both genetic and environmental factors. Epilepsy is the most popular childhood neurological condition and is characterized by an enduring predisposition to generate epileptic seizures, and the neurobiological, cognitive, psychological, and social consequences of this condition. Sleep and epilepsy are interrelated, and the importance of sleep in epilepsy is less known. The state of sleep also influences whether a seizure will occur at a given time, and this differs considerably for various epilepsy syndromes. The development of epilepsy has been associated with single or multiple gene variants. The genetics of epilepsy is complex and disorders exhibit significant genetic heterogeneity and variability in the expressivity of seizures. Phenobarbital (PhB) is the most widely used antiepileptic drug. With its principal mechanism of action to prolong the opening time of the γ-aminobutyric acid (GABA)-A receptor-associated chloride channel, it enhances chloride anion influx into neurons, with subsequent hyperpolarization, thereby reducing excitability. Enzymes that metabolize pharmaceuticals including PhB are well known for having genetic polymorphisms that contribute to adverse drug–drug interactions. PhB metabolism is highly dependent upon the cytochrome P450 (CYP450) and genetic polymorphisms can lead to variability in active drug levels. The highly polymorphic CYP2C19 isozymes are responsible for metabolizing a large portion of routinely prescribed drugs and variants contribute significantly to adverse drug reactions and therapeutic failures. A limited number of CYP2C19 single nucleotide polymorphisms (SNPs) are involved in drug metabolism. Extracellular vesicles (EVs) are circular membrane fragments released from the endosomal compartment as exosomes are shed from the surfaces of the membranes of most cell types. Increasing evidence indicated that EVs play a pivotal role in cell-to-cell communication. Theses EVs may play an important role between sleep, epilepsy, and treatments. The discovery of exosomes provides potential strategies for the diagnosis and treatment of many diseases including neurocognitive deficit. The aim of this study is to better understand and provide further knowledge about the metabolism and interactions between phenobarbital and CYP2C19 polymorphisms in children with epilepsy, interplay between sleep, and EVs. Understanding this interplay between epilepsy and sleep is helpful in the optimal treatment of all patients with epileptic seizures. The use of genetics and extracellular vesicles as precision medicine for the diagnosis and treatment of children with sleep disorder will improve the prognosis and the quality of life in patients with epilepsy.

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Section: Epilepsymentioning

confidence: 99%

Genetics and Extracellular Vesicles of Pediatrics Sleep Disordered Breathing and Epilepsy

Sanz-Rubio

2019

IJMS

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“…Parents of children with epilepsy are at high risk of having anxiety 4 . There are many recent studies on quality of life of the children with epilepsy and their parents' 4,[8][9][10][11][12] . Studies to address the behavioral/psychiatric problems often associated with childhood epilepsy and its effects on parent's anxiety are lacking 3 .…”

mentioning

confidence: 99%

Mental health problems in children with uncomplicated epilepsy; relation with parental anxiety

Gökgöz-Durmaz

Ci̇han

Meltem³

et al. 2016

Turk J Pediatr

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In those with epilepsy, 39.8% (n: 33) were girls, 60.2% (n: 50) were boys and their mean age was 9.34 ± 3.99 years. Control group was more successful in school (p<0.001). Emotional problems score in children with epilepsy was higher than control group (p<0.001). Case group's behavior problems and attention deficit hyperactivity scores were higher (p<0.001, p=0.009 respectively). Prosocial behavior scores of the control group were significantly higher (p=0.004). State (p=0.001) and trait (p=0.001) anxiety levels of parents of children with epilepsy were higher.Children with epilepsy have more neuro-behavioral problems; and their parents have greater anxiety levels. Physicians should be in contact with children with epilepsy for the psychological health of the family besides seizure control.

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“…Os FAEs de primeira geração (ex: fenobarbital, carbamazepina, fenitoína) possibilitam o controle das crises em menos de 70% da população, além da sua estreita margem terapêutica e grande variabilidade interindividual (PERSENIUS et al, 2015). Desta forma os FAEs de segunda geração (ex: topiramato, levetiracetam, tiagabina, gabapentina, lamotrigina) surgiram com o objetivo de proporcionar novas opções farmacológicas, além de trazer novas perspectivas para os pacientes com epilepsia.…”

Section: Epilepsiaunclassified

Avaliação da técnica de microextração em fase líquida com fibra oca (HF-LPME) para análise do topiramato em plasma e saliva por LC-MS/MS

Montanari¹

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Quality of life and sense of coherence in young people and adults with uncomplicated epilepsy: A longitudinal study

Cited by 11 publications

References 23 publications

Genetics and Extracellular Vesicles of Pediatrics Sleep Disordered Breathing and Epilepsy

Genetics and Extracellular Vesicles of Pediatrics Sleep Disordered Breathing and Epilepsy

Mental health problems in children with uncomplicated epilepsy; relation with parental anxiety

Avaliação da técnica de microextração em fase líquida com fibra oca (HF-LPME) para análise do topiramato em plasma e saliva por LC-MS/MS

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