Quality of life and radiotherapy in brain metastasis patients

Fernandez, Gonçalo; Pocinho, R.; Travancinha, C.; Netto, E.; Roldão, M.

doi:10.1016/j.rpor.2012.08.003

Cited by 22 publications

(15 citation statements)

References 36 publications

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“…They reported a mean survival time of only 3.1 months. Also in Fernandez et al study 40 median survival time for group of 39 patients (14 with lung cancer) treated with WBRT was only 3 months. Those results varied considerably from mean survival times in our study sample and other investigations of radiosurgical treatment.…”

Section: Discussionmentioning

confidence: 88%

Evaluation of results of linac-based radiosurgery for brain metastases from primary lung cancer

Jezierska

Adamska

Liebert

2014

Reports of Practical Oncology & Radiotherapy

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Section: Discussionmentioning

confidence: 88%

Evaluation of results of linac-based radiosurgery for brain metastases from primary lung cancer

Jezierska

Adamska

Liebert

2014

Reports of Practical Oncology & Radiotherapy

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“…Prior reports describe functional deterioration among patients with brain metastasEs, 25 but none appear to have examined linkages between specific metastasis or patient characteristics and impending disablement. Characteristics reported to be associated with reduced survival, e.g., number of metastases, were not predictive of declining mobility in our study, apart from performance status, 24 possibly due to the more limited time intervals examined, mean 36.6 days.…”

Section: Discussionmentioning

confidence: 99%

Nested Cohort Study to Identify Characteristics That Predict Near-Term Disablement From Lung Cancer Brain Metastases

Cheville

Basford

Parney

et al. 2017

Archives of Physical Medicine and Rehabilitation

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Objectives To test whether the presence of patient- and imaging-level characteristics: 1) are associated with clinically meaningful changes in mobility among late stage cancer patients with metastatic brain involvement; and 2) can predict their risk of near-term functional decline. Design Prospective nested cohort study Setting Quaternary academic medical center Participants The study population consisted of a nested cohort of the 66 patients with imaging confirmed brain metastases among a larger cohort of 311 patients with late stage lung cancer. Interventions Not applicable Main Outcomes Functional evaluations with the Activity Measure for Post-Acute Care Computer Adaptive Test (AM-PAC-CAT) and symptom intensity ratings were collected at monthly intervals for up to 2 years. Results In exploratory univariate models, whole brain radiation therapy (WBRT) and imaging findings of cerebellar or brain stem involvement were associated with large AM-PAC-CAT declines in mobility (−4.55, SE 1.12; −2.87, SE 1.0; and −3.14, SE 1.47, respectively). Also in univariate models, participants with new neurological signs or symptoms at imaging (−2.48, SE 0.99), new brain metastases (−2.14, SE 0.99), or new and expanding metastases (−2.64, SE 1.14) declined significantly. Multivariate exploratory mixed logistic models including WBRT, cerebellar/brainstem location, presence of new and expanding metastases, and worst pain intensity had excellent predictive capabilities for AM-PAC-CAT score declines of 7.5 and 10 points, C statistics ≥0.8. Conclusions Among patients with lung cancer and brain metastases, a cerebellar/brainstem location, new and expanding metastases, and treatment with WBRT may predict severe, near-term mobility losses and indicate a need to consider rehabilitation services.

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“…Despite a number of studies assessing QOL in patients with cancer, a standardized questionnaire does not exist to assess QOL in patients with BM, limiting full comparison with results of prior studies. Although certain parameters of QOL have worsened after WBRT in many studies (Fernandez, Pocinho, Travancinha, Netto, & Roldão, 2012;Gerrard et al, 2003;Steinmann et al, 2009;Wong et al, 2009), numerous studies have reported that QOL improved or did not change with WBRT in patients with BM (Addeo et al, 2007;Bezjak et al, 2002;Scott, Suh, Stea, Nabid, & Hackman, 2007;Takahashi et al, 2008;Yaneva & Semerdjieva, 2006). These varying results may be because of the heterogeneous population of patients with BM in different studies.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life, Psychological Burden, and Sleep Quality in Patients With Brain Metastasis Undergoing Whole Brain Radiation Therapy

Teke¹,

Bucaktepe²,

Kibrisli³

et al. 2016

CJON

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Statistically significant improvements were noted in KPS scores from baseline evaluation to the end of WBRT and to three months after WBRT. No significant differences were observed in SF-36 and HADS scores between the start and the end of WBRT. Anxiety scores were negatively correlated with survival at the end of WBRT. Overall survival was better in those who reported better sleep. WBRT improves KPS scores and does not worsen sleep quality or mood, even in patients with poor performance status. When changes in mood and sleep quality are observed, survival and QOL may improve in patients with BM; consequently, nurses should be responsive to these changes.

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Quality of life and radiotherapy in brain metastasis patients

Cited by 22 publications

References 36 publications

Evaluation of results of linac-based radiosurgery for brain metastases from primary lung cancer

Evaluation of results of linac-based radiosurgery for brain metastases from primary lung cancer

Nested Cohort Study to Identify Characteristics That Predict Near-Term Disablement From Lung Cancer Brain Metastases

Quality of Life, Psychological Burden, and Sleep Quality in Patients With Brain Metastasis Undergoing Whole Brain Radiation Therapy

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