Quality of life and exercise performance in unoperated children with anomalous aortic origin of a coronary artery from the opposite sinus of valsalva

Sing, Alan C.; Tsaur, Stephen; Paridon, Stephen M.

doi:10.1017/s1047951116001542

Cited by 9 publications

(7 citation statements)

References 42 publications

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“…On the other hand, medical patients have a restricted lifestyle, which may impact their own and families QoL, as reported by Sing et al [28], who demonstrated that patients' families were often experiencing a decreased level of general health and emotional and physical QoL scores. To minimize this, exercise restriction should be better defined and families should be better counselled, to understand that their children can participate in most activities.…”

Section: Discussionmentioning

confidence: 98%

Anomalous aortic origin of coronary arteries: Early results on clinical management from an international multicenter study

Padalino

Franchetti

Sarris

et al. 2019

International Journal of Cardiology

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Background: Anomalous aortic origin of coronary arteries (AAOCA) is a rare abnormality, whose optimal management is still undefined. We describe early outcomes in patients treated with different management strategies. Methods: This is a retrospective clinical multicenter study including patients with AAOCA, undergoing or not surgical treatment. Patients with isolated high coronary take off and associated major congenital heart disease were excluded. Preoperative, intraoperative, anatomical and postoperative data were retrieved from a common database. Results: Among 217 patients, 156 underwent Surgical repair (median age 39 years, IQR: 15-53), while 61 were Medical (median age 15 years, IQR: 8-52), in whom AAOCA was incidentally diagnosed during screening or clinical evaluations. Surgical patients were more often symptomatic when compared to medical ones (87.2% vs 44.3%, p b 0.001). Coronary unroofing was the most frequent procedure (56.4%). Operative mortality was 1.3% (2 patients with preoperative severe heart failure). At a median follow up of 18 months (range 0.1-23 years), 89.9% of survivors are in NYHA ≤ II, while only 3 elderly surgical patients died late. Return to sport activity was significantly higher in Surgical patients (48.1% vs 18.2%, p b 0.001). Conclusions: Surgery for AAOCA is safe and with low morbidity. When compared to Medical patients, who remain on exercise restriction and medical therapy, surgical patients have a benefit in terms of symptoms and return to normal

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Section: Discussionmentioning

confidence: 98%

Anomalous aortic origin of coronary arteries: Early results on clinical management from an international multicenter study

Padalino

Franchetti

Sarris

et al. 2019

International Journal of Cardiology

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“…4 We currently lack prospective longitudinal data providing evidence as to the best management strategy for these patients and if intervention alters the risk of suffering SCD. Previous studies on QOL assessment of these patients utilized generic PedsQL questionnaires and thus reported normal QOL score in unoperated 5 and operated AAOCA patients. 6 This is the first study to assess QOL and family impact, using cardiac specific (PCQLI) and PedsQL Family Impact Module following a diagnosis of AAOCA.…”

Section: Discussionmentioning

confidence: 99%

Decreased Quality of Life in Children With Anomalous Aortic Origin of a Coronary Artery

Agrawal

Mery

Sami

et al. 2021

World J Pediatr Congenit Heart Surg

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Background: Anomalous aortic origin of a coronary artery (AAOCA) is associated with sudden death in the young. We sought to determine quality of life (QOL) in patients/families affected by AAOCA. Methods: Patients with AAOCA (8-18 years) were prospectively included from January 2016 to May 2017. Parent proxy and patient Pediatric Cardiac Quality of Life Inventory (PCQLI) were used to evaluate QOL and Pediatric Quality of Life Inventory (PedsQL) Family Impact Module to assess the impact of AAOCA on families, as primary outcomes. Secondary outcomes included peer relationship, anxiety, and depression assessed using patient-reported outcomes measurement information system. Patients deemed high-risk were offered surgery/exercise restriction. Generalized linear mixed regression models were used to determine significant predictors of outcomes. Results: Fifty-three patients, the majority (n = 31, 59%) unrepaired, and 49 caregivers were included. Using PCQLI, patient and parent proxy QOL scores were similar to published scores for children with long-QT syndrome. Patients’ QOL score was associated with exertional symptoms, perceived chronic disease, and altered parent’s concentration ability. Likewise, parent proxy QOL scores were associated with mother’s living situation, exertional symptoms, parent missing work for ≥1 day, and disturbed parental functioning at work. Family impact scores were associated with lower maternal education, among other measures. Risk categories or surgical status did not impact patient, parent proxy reported, or family impact QOL. Conclusion: Anomalous aortic origin of a coronary artery is associated with decreased QOL as perceived by patients and caregiver and is associated with numerous facets of family functioning. These findings are independent of risk categorization or surgical status.

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“…A panel discussion with families affected by AAOCA during these meetings brought special attention to the psychosocial needs of patients as well as their parents and siblings. As in any other field of medicine, quality of life measurement should be standard of care for these patients and families . Improved counseling and measurement of exercise performance over time will help to improve the care and well‐being of these patients.…”

Section: Discussionmentioning

confidence: 99%

“…As in any other field of medicine, quality of life measurement should be standard of care for these patients and families. 17 Improved counseling and measurement of exercise performance over time will help to improve the care and well-being of these patients.…”

Section: Re S U Ltsmentioning

confidence: 99%

Current practices are variable in the evaluation and management of patients with anomalous aortic origin of a coronary artery: Results of a survey

Agrawal

Mery

Day

et al. 2017

Congenital Heart Disease

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Quality of life and exercise performance in unoperated children with anomalous aortic origin of a coronary artery from the opposite sinus of valsalva

Cited by 9 publications

References 42 publications

Anomalous aortic origin of coronary arteries: Early results on clinical management from an international multicenter study

Anomalous aortic origin of coronary arteries: Early results on clinical management from an international multicenter study

Decreased Quality of Life in Children With Anomalous Aortic Origin of a Coronary Artery

Current practices are variable in the evaluation and management of patients with anomalous aortic origin of a coronary artery: Results of a survey

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