Quality of Life and Comorbidities in Urticaria: What Is Known?

Gieler, Uwe; Gieler, Tanja; Schut, Christina; Niemeier, V.; Peters, Eva M.J.; Kupfer, Jörg

doi:10.1007/s13671-015-0105-6

Cited by 4 publications

(3 citation statements)

References 54 publications

(50 reference statements)

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“…diseases, type-2 diabetes, and cancer [35,36]. Moreover, these patho-physiological stressrelated processes are associated with a large number of other diseases such as chronic dermatological conditions (e.g., skin aging [37], urticaria [38,39], or skin tumors; [40]), asthma bronchiale [41,42], or obesity [43,44], and many more.…”

Section: Plos Onementioning

confidence: 99%

“…Ultimately, acute stress exposure leads to systemic low-grade inflammation, which is–in the long-term–a key factor for the development of the most important diseases in industrialized nations such as cardiovascular diseases, type-2 diabetes, and cancer [ 35 , 36 ]. Moreover, these patho-physiological stress-related processes are associated with a large number of other diseases such as chronic dermatological conditions (e.g., skin aging [ 37 ], urticaria [ 38 , 39 ], or skin tumors; [ 40 ]), asthma bronchiale [ 41 , 42 ], or obesity [ 43 , 44 ], and many more.…”

Section: Introductionmentioning

confidence: 99%

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Physiological stress in response to multitasking and work interruptions: Study protocol

et al. 2022

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Background The biopsychological response patterns to digital stress have been sparsely investigated so far. Important potential stressors in modern working environments due to increased digitalization are multitasking and work interruptions. In this study protocol, we present a protocol for a laboratory experiment, in which we will investigate the biopsychological stress response patterns to multitasking and work interruptions. Methods In total, N = 192 healthy, adult participants will be assigned to six experimental conditions in a randomized order (one single-task, three dual-task (two in parallel and one as interruption), one multitasking, and one passive control condition). Salivary alpha-amylase as well as heart rate as markers for Sympathetic Nervous System Activity, heart rate variability as measure for Parasympathetic Nervous System (PNS) activity, and cortisol as measure for activity of the hypothalamic-pituitary adrenal (HPA) axis will be assessed at six time points throughout the experimental session. Furthermore, inflammatory markers (i.e., IL-6, C-reactive protein (CRP), and secretory immunoglobulin-A) will be assessed before and after the task as well as 24 hours after it (IL-6 and CRP only). Main outcomes will be the time course of these physiological stress markers. Reactivity of these measures will be compared between the experimental conditions (dual-tasking, work interruptions, and multitasking) with the control conditions (single-tasking and passive control). Discussion With this study protocol, we present a comprehensive experiment, which will enable an extensive investigation of physiological stress-responses to multitasking and work interruptions. Our planned study will contribute to a better understanding of physiological response patterns to modern (digital) stressors. Potential risks and limitations are discussed. The findings will have important implications, especially in the context of digital health in modern working and living environments.

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Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physiological stress in response to multitasking and work interruptions: Study protocol

et al. 2022

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“…[9] There are certain comorbidities, frequently associated with urticaria: Autoimmunity, infections, allergy, emotional stress, and metabolic syndrome with dietary factors that can aggravate chronic urticaria (CU). [1,2,[10][11][12][13][14][15][16][17][18][19] Some patients have more than one concomitant disease. These patients are older, have longer duration of urticaria, and are more resistant to antihistamines.…”

Section: Indian Journal Of Skin Allergymentioning

confidence: 99%

Urticaria and comorbidities

Gotua

Agondi

Chérrez-Ojeda

2022

IJSA

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Urticaria is a mast cell (MC)-driven skin disease. Degranulation of these cells is triggered by the activation of several receptors on its surface. The activation of MC in chronic spontaneous urticaria (CSU) appears to be associated with an autoimmune etiology. Certain comorbidities such as autoimmunity, infections, allergy, emotional stress, and metabolic syndrome are frequently associated with chronic urticaria (CU). The objective of this review is to highlight the frequent association between CU and several comorbidities, which can lead to a worse prognosis for the underlying disease. We searched for original and review articles on CU and comorbidities in PUBMED, abstracts published in AAAAI and EAACI; all of them in English. Our review reinforced how CSU, being itself an autoimmune disease, is strongly linked to several other autoimmune diseases. Besides autoimmunity, emotional stress was considered another frequent comorbidity associated with CU and also a trigger factor for urticaria exacerbation. Some studies recently considered CU as a low-grade chronic inflammatory condition and may be associated with metabolic syndrome. In conclusion, CU is considered a heterogeneous disease with distinct clinical features. It is worth remembering that CU should not be considered just a skin disease and its complete control could minimize a worse clinical outcome.

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