Quality of Life and Cognitive Function of Liver Transplant Patients: A Prospective Study

Moore, Kathleen A.

doi:10.1053/jlts.2000.9743

Cited by 67 publications

(52 citation statements)

References 36 publications

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“…Kober et al 20 found that the QOL reported by men was less than the one reported by women, whereas in a later study Moore et al did not find any difference. 21 Results of QOL studies that used different tools should be compared with caution, however. 22 As in most of the studies published, we found that overall, LT improves the QOL of patients considerably as a whole.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal prospective evaluation of quality of life in adult patients before and one year after liver transplantation

Karam

Castaing

Danet

et al. 2003

Liver Transplantation

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We assessed the impact of liver transplantation (LT) on the quality of life (QOL) of French recipients 1 year after surgery. A French version of the questionnaire used by the National Institute of Diabetes and Digestive and Kidney Disease-Pittsburg, USA (NIDDK), was validated by the back-translation method. Five QOL domains were evaluated: measures of disease, psychological distress, personal function, social function, and general health perception. Patients enrolled onto the waiting list completed the questionnaire before and 1 year after LT. Respondents were age-and gender-matched with healthy subjects recruited from the general population (GP). One year after LT, the analysis of data from 67 consecutive patients showed dramatic improvement in the five domains. Compared with baseline, patients noted fewer disease-related symptoms (P < .0001) and lower level of distress overall (P < .001). However, levels of distress caused by excess appetite (P < .01), trembling (P < .05), and headaches (P ‫؍‬ .06) were more likely to increase than decrease. Twenty-five percent of patients prevented by their disease from going to work before LT were no longer so limited at 1-year follow-up. General health perception improved remarkably, with seven times as many recipients reporting improved health as reporting worse health. A correlation was found between the pretransplantation severity of cirrhosis and the social and role function after LT (P < .05). In summary, the French version of the NIDDK questionnaire seems to be reliable. The results of transplant recipients were generally close to those of the general population. Although it is not a true return to normal status, it approaches it. (Liver Transpl 2003;9:703-711.)

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Section: Discussionmentioning

confidence: 99%

Longitudinal prospective evaluation of quality of life in adult patients before and one year after liver transplantation

Karam

Castaing

Danet

et al. 2003

Liver Transplantation

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“…It has been shown that cognitive deficits detectable in patients with end-stage liver failure improve after transplantation, [5][6][7][8] but whether this improvement is maintained in the long term is unknown.…”

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confidence: 99%

Cognitive dysfunction and health-related quality of life in long-term liver transplant survivors

Lewis

Howdle

2003

Liver Transplantation

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Although several studies have investigated short-term effects of liver transplantation on cognitive function and health-related quality of life, there have been no studies looking at long-term effects. Patients who received a single liver transplant at St James's University Hospital (Leeds, UK) before October 1, 1991, were invited to participate in this cross-sectional study. Cognitive function was assessed using the Mini-Mental State Examination, the Rey Auditory Verbal Learning Test, trail-making tests, the Stroop test, and the Benton Visual Retention Test. Anxiety and depression were documented using the Hospital Anxiety and Depression Scale. Health-related quality of life was assessed using the EuroQol. Twenty-five healthy volunteers acted as controls. Thirty-six patients had undergone transplantation before October 1, 1991. Thirteen patients (36%) had died, 6 patients had received more than one transplant, 2 patients did not speak English, and 3 patients did not want to participate, leaving 12 patients included in the study. Patients scored significantly lower on measures of health-related quality of life than healthy controls, but there were no differences in levels of anxiety or depression. Patients scored significantly lower than controls across a wide range of cognitive functions, suggesting global cognitive impairment. We show that patients who survive for more than 10 years after liver transplantation have significant cognitive dysfunction and poor health-related quality of life. Whether these patients never return to normal after transplantation or whether they experience an increased rate of decline in cognitive function and health-related quality of life is uncertain and requires further study. O ne-year survival rates for liver transplantation now exceed 90% in some centers and soon are expected to exceed 70% at 10 years. 1 Many studies have looked at short-term effects of liver transplantation, but very few are looking at long-term effects. 2,3 To our knowledge, no study has explored cognitive function or health-related quality of life in extremely long-term survivors of liver transplantation (Ͼ10 years). One of the few studies looking at long-term outcome followed up patients for up to 5 years and concluded that improvements seen in health-related quality of life continued to this time. 4 Another similar cross-sectional study by De Bona et al 3 managed to recruit seven patients who had received their transplants 49 to 60 months previously. They showed there was an initial improvement in health-related quality of life and psychological distress, followed approximately 6 months later by a further decline, which then began to resolve again after approximately 36 months. These studies did not have patients who underwent transplantation more than 5 years previously.It has been shown that cognitive deficits detectable in patients with end-stage liver failure improve after transplantation, 5-8 but whether this improvement is maintained in the long term is unknown.Cognitive problems faced by these patie...

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“…In another composite analysis published in 1999, Bravata et al concluded that there were no differences between the sexes in post-LTx QOL, although the authors commented on the scarcity of studies dealing with this topic (Bravata et al, 1999). Moore came to the same conclusion in a single-center prospective study of 10 LTx recipients compared to normal controls (Moore et al, 2000).…”

Section: Gender Differencesmentioning

confidence: 95%

Quality of Life and Physical Activity after Liver Transplantation. Literature Review.

Stępień–Słodkowska

Niewiadomska

Kotarska

2017

Central European Journal of Sport Sciences and Medicine

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Liver transplantation has become one of the most effective treatments for end-stage renal disease. For patients, however, the decision to have orthotopic liver transplantation (OLT) is often made in an effort to improve their quality of life and to reduce their risk of mortality and morbidity. Quality of life is an important aspect of therapy for transplant patients because this category reflects the subjective evaluation of one's own life in the physical, psychological and social dimensions. One of the means to achieve a better quality of life is not only good health, but also physical activity. Physical activity has been demonstrated to be of significance not only in the assessment of fitness levels but also could be of importance in long term recovery process after major surgical operations. The aim of this study was a review of literature showing the improved quality of life in patients after liver transplantation as well as the influence of physical activity on their physical health, mental health and quality of life after transplantation. Longitudinal data showed remarkable improvement of common domains of QOL comparing pre-and post-transplant items. Gender, occupation and regular physical activity have an influence on the quality of life after liver transplantation.

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Quality of Life and Cognitive Function of Liver Transplant Patients: A Prospective Study

Cited by 67 publications

References 36 publications

Longitudinal prospective evaluation of quality of life in adult patients before and one year after liver transplantation

Longitudinal prospective evaluation of quality of life in adult patients before and one year after liver transplantation

Cognitive dysfunction and health-related quality of life in long-term liver transplant survivors

Quality of Life and Physical Activity after Liver Transplantation. Literature Review.

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