Quality of life and clinical correlates in patients with diabetic foot ulcers

Valensi, P.; Girod, I; Baron, Florence; Moreau-Defarges, T; Guillon, P.

doi:10.1016/s1262-3636(07)70193-3

Cited by 107 publications

(122 citation statements)

References 25 publications

Supporting

Mentioning

104

Contrasting

Unclassified

Order By: Relevance

“…In our study as well as in the literature, disability was associated with aging (13,14). Thus, even though the primary healing rate observed in our series might be considered satisfactory and is in agreement with those of published prospective studies with a similar follow-up duration (5,6,15), GTS for foot care, as defined by healing and absence of recurrence and disability, occurred in Ͻ50% of the patients (44.9%).…”

Section: Mortalitysupporting

confidence: 92%

“…The primary healing rate was 77.5%, but the years after the initial event were marked by high rates of ulcer recurrence (60.9%) and amputations (43.8%). At the end of the follow-up period or at the time of their death, 28.1% of the patients were considered to have a disability leading to dependency, which is one of the essential criteria used to evaluate functional status (13). To our knowledge, no data concerning prospective evaluation of disability or dependency in diabetic subjects with foot ulcers are available nor has it ever been considered as a therapeutic criterion in any previous study.…”

Section: Mortalitymentioning

confidence: 99%

See 1 more Smart Citation

Long-Term Outcome and Disability of Diabetic Patients Hospitalized for Diabetic Foot Ulcers

Ghanassia

Villon²,

Dieudonné³

et al. 2008

Diabetes Care

172

120

View full text Add to dashboard Cite

OBJECTIVE -The long-term outcome and functional status of subjects hospitalized for diabetic foot ulcers have been poorly studied and thus are the topics of this study.RESEARCH DESIGN AND METHODS -Ninety-four consecutive diabetic subjects hospitalized for diabetic foot ulcers between January 1998 and December 2000 were prospectively followed for mean Ϯ SD 79.5 Ϯ 13.3 months. We calculated rates of primary healing, new ulcers, amputations, mortality, and disability and evaluated the global therapeutic success (GTS) of foot care management as defined by the association of primary healing without recurrence or disability at the end of follow-up.RESULTS -Follow-up was successful in 89 of 94 subjects (63 men and 31 women; age 63.7 Ϯ 10.8 years). Of these, 69 (77.5%) experienced primary healing without major amputation, 39 (43.8%) underwent amputation (24 minor and 15 major), and 46 died (51.7%), including 23 from cardiovascular events. Forty-two of 69 patients who experienced primary healing (60.9%) had ulcer recurrence. At the end of the follow-up period, 25 patients (28.1%) were dependent and 40 subjects (44.9%) had achieved GTS. Multivariate analysis showed the role of age as an independent predictor of GTS (P Ͻ 0.05) and of impaired renal function/ albuminuria as independent predictors of healing failure, first amputation, and mortality (P Ͻ 0.01).CONCLUSIONS -Despite a satisfactory initial healing rate, the global long-term outcome of patients hospitalized for diabetic foot ulcers was poor. Nephropathy appears to be an important predictor of long-term outcome. Further studies are needed to establish recognized criteria for therapeutic success going beyond just the evaluation of healing rate in the management of diabetic foot ulcers.

show abstract

Section: Mortalitysupporting

confidence: 92%

Section: Mortalitymentioning

confidence: 99%

Long-Term Outcome and Disability of Diabetic Patients Hospitalized for Diabetic Foot Ulcers

Ghanassia

Villon²,

Dieudonné³

et al. 2008

Diabetes Care

172

120

View full text Add to dashboard Cite

show abstract

“…A weakness of the current study is that HRQoL was not measured with a disease-specific scale, for example, the DFU scale (29), which would yield more adequate HRQoL measurement. Studies that investigate HRQoL in patients with DFU mostly use the generic Rand SF-36 (30)(31)(32), sometimes in combination with a disease-specific scale (29).…”

Section: Al (5)mentioning

confidence: 99%

“…Studies that investigate HRQoL in patients with DFU mostly use the generic Rand SF-36 (30)(31)(32), sometimes in combination with a disease-specific scale (29). In contrast, EQ-5D is more used in studies on diabetes in general and its complications (33)(34)(35).…”

Section: Al (5)mentioning

confidence: 99%

Health-Related Quality of Life Predicts Major Amputation and Death, but Not Healing, in People With Diabetes Presenting With Foot Ulcers: The Eurodiale Study

et al. 2014

View full text Add to dashboard Cite

Low health-related quality of life (HRQoL) has been consistently reported to be associated with poor prognosis for a variety of health outcomes in various settings. We aimed to evaluate whether HRQoL in patients presenting with new diabetic foot ulcers (DFUs) has prognostic significance for ulcer healing, major amputation, and death. RESEARCH DESIGN AND METHODSWe followed 1,088 patients with new DFUs presenting for treatment at one of the 14 centers in 10 European countries participating in the Eurodiale (European Study Group on Diabetes and the Lower Extremity) study, prospectively until healing (76.9%), major amputation (4.6%), or death (6.4%) up to a maximum of 1 year. At baseline, patient and ulcer characteristics were recorded as well as EQ-5D, a standardized instrument consisting of five domains and a visual analog scale for use as a measure of HRQoL. The prognostic influence of the EQ-5D domains was evaluated in multivariable Cox regression analyses on the time-to-event data, adjusting for baseline clinical characteristics of the ulcer and comorbidities. RESULTSWhile predictive effects of HRQoL, adjusted for possible confounders, were absent for healing, decreased HRQoL, especially in the physical domains, was statistically significant for major amputation (mobility, self-care, usual activities) and death (self-care, usual activities, pain/discomfort). CONCLUSIONSLow HRQoL appears to be predictive for major amputation and death, but high HRQoL does not increase healing. Future studies into the influence of HRQoL on ulcer outcome are important in attempts to decrease treatment failure and mortality.

show abstract

“…Our findings are in agreement of several studies that also focus on quality of living among patients struggling Diabetic Foot Ulcer. Such studies are by Valensi et al (2005) and Ribu et al (2006), of which both studies use the SF-36 Questionnaires and these two studies were both crosssectional and observational design, only that Ribu et al (2006) compared the scores of patients with DFU ulcer score to the general population without Diabetes where as Valensi et al (2005) compared the QOL among Diabetic patients with and without DFU. These studies however, did not measure HBOT influence on ulcer healing and quality of living.…”

Section: Discussionmentioning

confidence: 99%

The Physiological, Biochemical and Quality of Life Changes in Chronic Diabetic Foot Ulcer after Hyperbaric Oxygen Therapy

Bajuri¹,

Ayesyah²,

Ab³

et al. 2017

View full text Add to dashboard Cite

ABSTRAK Terapi Oksigen Hiperbaric (TOH) dikesan dapat meningkatkan pengoksigenan dan kesan anti-mikrob yang berpotensi meningkatkan penyembuhan ulser kronik. Kajian ini bertujuan menilai kesan TOH dalam ulser kaki diabetik (UKD) yang kronik. Seramai enam puluh pesakit dikelaskan mengikut ABSTRACTHyperbaric oxygen therapy (HBOT) was established to increase oxygenation and antimicrobial effect that potentially improve the healing of chronic ulcer. Present study aim to assess the effects of HBOT in chronic diabetic foot ulcer (DFU). A total of sixty patients classified according to Wagner 1, 2 or 3 chronic diabetic foot ulcers, were recruited and subsequently divided randomly into two groups; HBOT and control group. All patients underwent the standard treatment for DFU, but for the HBOT group, underwent 20 HBOT sessions, each lasted 80 -90 mins at 2.5 atmospheres absolute (ATA). White cell count (WCC) and C-reactive protein (CRP) levels were taken during inclusion, at second and fourth week of treatment. Wound sizes were documented at each follow up until six months follow up. SF-36 at one-month post hyperbaric oxygen therapy was used to measure the health-related quality of life. Reduction of WCC and CRP in HBOT group were significant throughout the treatment (p=0.046 and p=0.039, respectively). A total of 26 patients (86.7%) from the HBOT group achieved complete ulcer healing at six months' follow-up, while 18 patients (60%) in the control group's ulcer healed completely. Patients treated with HBOT had significantly better mental and physical health constituent of quality of life. It must be emphasised that HBOT is an adjunctive therapy to the standard management of chronic DFU in accelerating wound healing for a better quality of life.

show abstract

Quality of life and clinical correlates in patients with diabetic foot ulcers

Cited by 107 publications

References 25 publications

Long-Term Outcome and Disability of Diabetic Patients Hospitalized for Diabetic Foot Ulcers

Long-Term Outcome and Disability of Diabetic Patients Hospitalized for Diabetic Foot Ulcers

Health-Related Quality of Life Predicts Major Amputation and Death, but Not Healing, in People With Diabetes Presenting With Foot Ulcers: The Eurodiale Study

The Physiological, Biochemical and Quality of Life Changes in Chronic Diabetic Foot Ulcer after Hyperbaric Oxygen Therapy

Contact Info

Product

Resources

About