Quality of Life Amongst Multidrug-Resistant TB Patients: An Exploratory Study About Distributive Dimensions and Interactions

Abstract

Background: Multidrug-resistant (MDR)-TB has emerged as a major challenge to eliminate TB as envisioned at policy level. Distinctive traits associated with the disease such as physical, psychosocial and environmental dimensions may influence the treatment outcome in both directions. Quality of life (QoL) indicators may capture these traits distinctively.Objective: To quantify the differential effect of MDR-TB on specific QoL domains, their distributions across the strata and to check for possible interactions.Method: This community-based cross-sectional study was conducted on 98 MDR-TB patients registered in the calendar year 2017 under National Tuberculosis Elimination Programme (NTEP) in a central Indian district using the WHO-QoL BREF Scale by patients in their vicinity. The transformed domain scores were descriptively summarized, stratified and exploratory visualised. Likert mapping for each item was done. A two-way ANOVA test was applied to check differences across strata and interaction effects were calculated.Result: Participants perceived a higher QoL in the social domain (median score 69, IQR 56-75) while the psychological health domain (median 31 IQR 20.5-44) was professed as most negotiated by disease. More than 50% of participants were found to be dissatisfied with their assumed physical status in item-wise analysis. A statistically significant interaction (p=0.008) was detected with education strata to income tertile most evident in the physical domain while psychological domain alone (p=0.017) without significant interaction with treatment duration (p=0.316) was associated with the type of TB. Overall QoL scores were tilted in favour of an urban setting, male gender and towards a relatively younger population. Conclusion:The overall deficits in QoL are evident in the study, per se in the psychological and physical domains. Moreover there is an inequitable distribution of these scores as revealed in the study. Inclusion of an additional parameter of periodical QoL assessment may thus predict the outcome at individual level and may address this inequity at policy level.

A complementary approach to measure construct validity of WHO QOL BREF in Indian multidrug-resistant tuberculosis (MDR-TB) patients through psychometric property and factor analysis

“…The detailed descriptions of the participants' profile and their transformed score distributions are published elsewhere. 22 This section focuses entirely on the validity and reliability perspective of the tool to measure QoL among MDR TB patients.…”

“…We performed DIF analysis for gender, duration of treatment (<14 months versus >14 months) and as per categorisation of patients (newly diagnosed versus old patients). Question related to personal safety and security (8), sexual activity ( 21), social support (22) and home environment (23) were perceived differently by male and female participants. This difference was found to be statistically significant.…”

“…It also consists of one item from Social relationship domain i.e. social support (22). This dimension can be rephrased as "peripheral self".…”