Quality of life among patients on levothyroxine: A cross-sectional study

Quran, Thekraiat Al; Bataineh, Ziad; Al-Mistarehi, Abdel-Hameed; Okour, Abdulhakeem; Yonis, Othman Beni; Khassawneh, Adi; AbuAwwad, Rana; qura'an, Anood Al

doi:10.1016/j.amsu.2020.10.030

Cited by 13 publications

(14 citation statements)

References 28 publications

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“…Our results are in line with and comparable to what has been seen in cross-sectional studies and prospective trials at endocrine clinics. 7,11,12 Among the patients in this study, goiter symptoms, poor social life, and eye symptoms were among the least evident clinical findings. Findings from other studies on these findings were found identical to the present study.…”

Section: Discussionmentioning

confidence: 70%

“…Furthermore, because many thyroid illnesses can be treated in a variety of methods (e.g., radioiodine, medicinal treatment, or surgery), precise information of the influence of each treatment modality on patients' HRQL is essential. 4,7,8 Despite significant progress in developing clinical diagnostic and therapeutic standards for managing hyperthyroidism, the impact of these management standards on patient health and QOL is not addressed properly. Keeping this in view, present study was designed with objective to evaluate the influence of thyroid hormones as well as the effect of treatment choice on the quality of life of patients visiting / admitted in tertiary healthcare centers in Karachi, Sindh Pakistan.…”

Section: Introductionmentioning

confidence: 99%

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Influence of thyroid hormones and effect of treatment choice on the quality of life of hyperthyroid patients.

Salman¹,

Iqbal

Ahmed

et al. 2023

TPMJ

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Objective: To evaluate the influence of thyroid hormones as well as the effect of treatment choice on the quality of life of patients visiting / admitted in tertiary healthcare centers in Karachi, Sindh Pakistan. Study Design: Cross-sectional study. Setting: Rafae Aam General Hospital Federal Area Karachi, Sindh, Pakistan. Period: March 2022 to June 2022. Material & Methods: Patient’s data related to their socio-demographic and clinical details was collected by using a pre-tested written questionnaire. Brazilian version of 36-Item Short Form Health Survey questionnaire was completed by all the study participants. Results: Total 337 participants were included in the study. Mean age of the study participants was 34.03 ± 10.06. Majority of them were females while most of them belonged to the age group of 18-29 years. Most of our study participants were urban residents, married, having no any formal education and suffering from comorbidities. Based on clinical examination, 272 (80.7%) patients were found euthyroidism while 65 (19.3%) were hyperthyroid. Thus, hyperthyroid patients displayed a greater toll on the quality of life, particularly in areas of physical (59.62 vs. 82.81; p<0.05) as well as emotional (61.54 vs. 82.81; p<0.05) functioning. Conclusion: This study concludes that hyperthyroid patients have a significant quality of life impairment, particularly in the physical and emotional domains. Moreover, regardless of the findings of the serum thyroid hormone levels, quality of life of hyperthyroid patients is compromised.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Influence of thyroid hormones and effect of treatment choice on the quality of life of hyperthyroid patients.

Salman¹,

Iqbal

Ahmed

et al. 2023

TPMJ

View full text Add to dashboard Cite

show abstract

“…Results from two cross-sectional studies showed that, compared with general population samples, there were small but significant impairments in QoL among patients treated with LT4 [ 20 , 21 ]. Quran et al found that all domains (using ThyPRO) were impacted in patients receiving LT4 therapy [ 22 ]. Moreover, a prospective cohort study observed that full recovery was not obtained in patients with autoimmune hypothyroidism, despite most aspects improving after 6 months of LT4 therapy [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Relatively Lower FT3 Levels Are Associated with Impaired Quality of Life in Levothyroxine-Treated Patients with Hashimoto Thyroiditis

Cui

Ding

Bian

et al. 2022

International Journal of Endocrinology

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Objective. Patients with Hashimoto thyroiditis (HT) frequently have some complaints despite achieving euthyroidism after levothyroxine (LT4) treatment. This study aimed to investigate the relevant factors affecting the quality of life (QoL) in euthyroid HT patients after LT4 treatment. Methods. In this case-control study, 133 participants with HT were included. They were divided into two groups: 64 euthyroid HT subjects (control group) and 69 HT patients were rendered euthyroid by LT4 treatment (well-controlled group). QoL was measured with the Thyroid-Related Patient-Reported Outcome (ThyPRO-39) questionnaire. Results. Both study groups were well matched with respect to gender, age, BMI, euthyroidism, and thyroid antibodies (TPOAb and TGAb). Compared with the control group, the well-controlled group had lower FT3 ( P < 0.01 ) levels. Of note, QoL was impaired on all scales in the well-controlled group. Moreover, ThyPRO-39 scores among the well-controlled group were significantly higher (worse) than the control group in all scales. Regarding the composite scale, its score was related to FT3 (r = −0.176, P = 0.043 ) but not to FT4 and TSH levels. Further logistic regression analysis revealed FT3 was significantly associated with elevated composite QoL [0.128 (0.029–0.577), P < 0.01 ] after adjustment of potential confounders. Conclusion. Relatively lower FT3 concentrations, even within the normal reference range, were related to impaired QoL in HT patients treated with LT4. This finding supports the great value of FT3 in clinical decision-making on dose adequacy.

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“…Relevant research so far focused mainly on the question of whether different treatments can improve quality of life. In relation to the replacement of the hormone thyroxine, it has been shown to improve quality of life, but the effect depends primarily on whether the hormone replacement reduces comorbid symptoms and disorders (Al Quran et al, 2020). Studies related to surgeries shown that complete thyroid removal may be more effective in improving the quality of life than medication, which may be related to the possibility autoimmune processes being significantly reduced in the absence of the target tissue (Bektas Uysal & Ayhan, 2016).…”

Section: Psychological Knowledge About Hashimoto's Diseasementioning

confidence: 99%

Hashimoto's thyroiditis in health psychological approach

Rigó

2022

Clinical Health Psychology in Practice

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Quality of life among patients on levothyroxine: A cross-sectional study

Cited by 13 publications

References 28 publications

Influence of thyroid hormones and effect of treatment choice on the quality of life of hyperthyroid patients.

Influence of thyroid hormones and effect of treatment choice on the quality of life of hyperthyroid patients.

Relatively Lower FT3 Levels Are Associated with Impaired Quality of Life in Levothyroxine-Treated Patients with Hashimoto Thyroiditis

Hashimoto's thyroiditis in health psychological approach

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