Quality of Life After Palliative Radiation Therapy for Patients With Painful Bone Metastases: Results of an International Study Validating the EORTC QLQ-BM22

Zeng, Liang; Chow, Edward; Bedard, Gillian; Zhang, Liying; Fairchild, Alysa; Vassiliou, Vassilios; El-Din, Mohamed A. Alm; Filho, Reynaldo Jesus Garcia; Kumar, Aswin; Forges, Fabien; Tseng, Ling‐Ming; Hou, Ming‐Feng; Chie, Wei‐Chu; Bottomley, Andrew

doi:10.1016/j.ijrobp.2012.05.028

Cited by 82 publications

(72 citation statements)

References 17 publications

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“…To determine whether patients with an intermediate level of PD at baseline might have more chance of converting to a high level of PD during follow-up, the patients below the cutoff value were divided into two groups: low (7)(8)(9)(10)(11) and an intermediate (12)(13)(14)(15)(16) level.…”

Section: Psychological Distressmentioning

confidence: 99%

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Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

et al. 2017

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Background: Psychological distress (PD) has a major impact on quality of life. We studied the incidence of PD before and after radiotherapy for painful bone metastases. Furthermore, we aimed to identify factors predictive for PD. Methods: Between 1996 and 1998, the Dutch Bone Metastasis Study included 1157 patients with painful bone metastases. Patients were randomized between two fractionation schedules. The study showed a pain response of 74% in both groups. Patients filled out weekly questionnaires for 13 weeks, then monthly for two years. The questionnaires included a subscale for PD on the Rotterdam Symptom Checklist. We used generalized estimating equations and multivariable logistic regression analyses. Results: At baseline, 290 patients (27%) had a high level of PD. For the entire group, the level of PD remained constant over time. The majority of patients with a low level of PD at baseline remained at a low level during follow-up. In patients with a high level of PD at baseline, the mean level of PD decreased after treatment and stabilized around the cutoff level. Female patients, higher age, worse performance, lower pain score and worse self-reported QoL were associated with an increased chance of PD, although the model showed moderate discriminative power. Conclusions: A substantial proportion of patients had a high level of PD before and after radiotherapy for painful bone metastases. Most patients who reported high levels of PD when referred for palliative radiotherapy remained at high levels thereafter. Therefore, screening of PD prior to treatment seems appropriate, in order to select patients requiring intervention.

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Section: Psychological Distressmentioning

confidence: 99%

“…Painful bone metastases have a negative impact on the QoL of patients [5,6]. Studies show that radiotherapy stabilizes or improves QoL [7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

et al. 2017

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“…Although a few studies showed that radiotherapy for painful bone metastases contributes to improvement of QoL, no thorough studies have been published focusing on the course of QoL after radiotherapy. (4,(6)(7)(8) These patients frequently have other contributing factors that influence QoL, like visceral metastases, deteriorating physical condition, psychosocial issues or side-effects from systemic treatments. (4,9) Furthermore, adequate treatment of pain at one site might unmask pain at other sites, resulting in migrating pain.…”

Section: Introductionmentioning

confidence: 99%

“…To our knowledge only one publication compared QoL in 22 responding patients versus 8 non-responders. (8) Moreover, it would be helpful to identify the remaining 30-40% of patients who will not respond to radiotherapy, in order to prevent overtreatment and loss of valuable time. These patients might benefit more from a change in pain medication (10) or other treatments, such as radiopharmaceuticals (11), bisphosphonates (12,13), minimally invasive surgery (14,15) and/or systemic therapy.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Relation to Pain Response to Radiation Therapy for Painful Bone Metastases

Westhoff

Graeff

Monninkhof

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

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“…This greatly improves the quality of life for many patients with disseminated cancer. 119 There is also evidence of a reduction in lesion viability after HIFU and a remineralisation of spongious bone. 120 Tumour ablation in curative treatment aims for complete coagulation necrosis of the primary lesion.…”

Section: Bone Metastasesmentioning

confidence: 99%

Clinical applications of high-intensity focused ultrasound

et al. 2016

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Quality of Life After Palliative Radiation Therapy for Patients With Painful Bone Metastases: Results of an International Study Validating the EORTC QLQ-BM22

Cited by 82 publications

References 17 publications

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

Quality of Life in Relation to Pain Response to Radiation Therapy for Painful Bone Metastases

Clinical applications of high-intensity focused ultrasound

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