Quality of life after hepatic resection

Studer, Peter; Horn, T.; Haynes, Alan G.; Candinas, Daniel; Banz, Vanessa

doi:10.1002/bjs.10735

Cited by 16 publications

(16 citation statements)

References 26 publications

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“…In this study, patients older than 40 years showed comparable overall PCS after the RF procedure compared to that of the general German control population. This is in contrast to HRQoL reports after HR, where HRQoL regularly shows an initial decline with considerable improvement after 6 months with the highest scores after 24 months 6 . According to Toro et al and Dasgupta et al 27 , 28 this pattern may be indicative of the regenerative capacity of the liver.…”

Section: Discussioncontrasting

confidence: 99%

“…Regarding hepatic neoplasms, hepatic resection (HR) is considered to be the gold standard in the management of both primary and metastatic disease. However, HR is still associated with relatively high morbidity rates up to 59.9% 2 – 5 and with a corresponding initial decline in HRQoL after surgery 6 . Radiofrequency ablation (RF) affords more rapid post-procedure recovery and thus good post-procedure HRQoL by virtue of its minimally invasive nature, and has been increasingly accepted as an alternative in the management of primary or metastatic liver tumors 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

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Quality of life analysis after stereotactic radiofrequency ablation of liver tumors

Schullian

Gertl

Laimer

et al. 2020

Sci Rep

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The purpose of this study was to evaluate the health-related quality of life (HRQoL) after stereotactic radiofrequency ablation (SRFA) of liver tumors and identify variables associated with decreased HRQoL and to compare it to other treatments in case of concurrency. From 2011 to 2017 577 patients underwent SRFA for liver tumors in 892 ablation sessions. 303 (52.5%) patients completed a HRQoL questionnaire once after the ablation. HRQoL was assessed by the Short Form (SF)-12 health survey with mental and physical component scales and by a general questionnaire to assess disease and treatment-specific items as well as to compare tolerability of SRFA to transarterial chemoembolization (TACE), hepatic resection (HR) and chemotherapy (CTX). The median SF-12 PCS was 46.6 and MCS was 53.2. Patients experiencing pain or complications and patients refusing repeat SRFA showed significantly lower PCS (43.2 vs 48.6, p = 0.0003; 32.8 vs 46.9, p = 0.005 and 40.6 vs 46.9, p = 0.009). 355 (97.8%) patients indicated willingness to undergo repeat SRFA with little to no fear in 292 (80.7%) patients. Among patients with multiple therapies, SRFA was rated by 40 (90.9%) as preferred re-treatment, HR by 1 (2.3%) and CTX by 3 (6.8%). In conclusion, we have shown that SRFA has good HRQoL-outcomes and reported low morbidity rates. Consequently the vast majority of study patients would accept a repeated SRFA if necessary (97.8%), without fear (80.7%). SRFA was preferred among patients who experienced concurrent treatments, such as HR or CTX.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quality of life analysis after stereotactic radiofrequency ablation of liver tumors

Schullian

Gertl

Laimer

et al. 2020

Sci Rep

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“…Such a study enables researchers to identify areas of care that may need particular attention, while learning those to which patients may adapt naturally. Similar common human reactions were identified in the study of patients following hepatic resection, indicating that those with malignant and benign disease had similar QoL measurements. As the only treatment possible for survival, it would seem that the malignant group attuned themselves to the situation.…”

supporting

confidence: 64%

Quality of life and patient-reported outcomes

Church

2018

British Journal of Surgery

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“…11 In recent years, more studies have started reporting QoL, recognizing its place as an important perioperative and longer term outcome measure. [12][13][14] Up until now there has been no systematic review or meta-analysis evaluating this subject.…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta-analysis on the quality of life after hepatic resection

Wee

Syn

Lee

et al. 2020

HPB

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Background: Quality of life (QoL) after hepatic resection is a pertinent issue that has been poorly studied. The aim of this study was to compare changes in QoL before and after hepatic resection. Methods: A systematic review was performed using Medline, EMBASE, and the Cochrane library. Whenever possible, pooled mean differences of survey scores pre-and post-operatively were calculated. Results: 22 studies were included comprising a total of 1785 participants. Using the EORTC-QLQ 30C survey, patients with benign disease tend to have better QoL post-surgery than those with malignant disease. There were post-operative improvements in the following FACT-HEP domains: physical at 9 months (MD 3.14, 95%CI 2.70 to 3.58, P < 0.001), social and family at 3 (MD 1.45, 95%CI 0.12 to 2.77, p = 0.030), 6 (MD 1.12, 95%CI 0.21 to 2.04, p = 0.020), 9 (MD 0.66, 95%CI 0.03 to 1.28, p = 0.040), and 12 (MD 0.58, 95%CI 0.12 to 1.03, p = 0.010) months, emotional at 9 (P < 0.001) and 24 months (P < 0.001), hepatobiliary at 24 months (p < 0.001), and global health status at 9 months (p = 0.002). Conclusion: QoL scores tend to deteriorate post-surgery, but recover to baseline in the long-term at 9months. Patients with malignant disease, and those who underwent major hepatectomy, have poorer QoL scores.

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Quality of life after hepatic resection

Abstract: This study confirmed overall good QoL in patients undergoing liver resection for benign or malignant tumours, which improved after surgery. Benign diseases were associated with better short- and long-term QoL scores.

Cited by 16 publications

References 26 publications

Quality of life analysis after stereotactic radiofrequency ablation of liver tumors

Quality of life analysis after stereotactic radiofrequency ablation of liver tumors

Quality of life and patient-reported outcomes

A systematic review and meta-analysis on the quality of life after hepatic resection

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