Quality marker discovery of Danggui Jianzhong decoction for treating primary dysmenorrhoea based on chinmedomics strategy

Wang, Ying; Yang, Lei; Zhang, Xiwu; Sun, Ye; Sun, Hui; Ge, Yan; Zhao, Qiqi; Han, Ying; Wang, Xijun

doi:10.1016/j.phymed.2023.154724

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…According to results of ELISA, ZZCD can exert antidepressant and anxiety effects by reducing the levels of pro‐inflammatory factors (IL‐1β and TNF‐α) in peripheral blood, increasing the levels of anti‐inflammatory factors (IL‐10) and neurotransmitters (5‐HT, DA and GABA), and regulating HPA axis hormones (CRH, ACTH, and CORT). Similar to our results, previous reports have shown changes in these neurotransmitters, pro‐inflammatory cytokines and HPA axis hormones in the depression mice 34–36 . These results indicate that ZZCD can intervene in depression by regulating the HPA axis and peripheral immunity.…”

Section: Discussionsupporting

confidence: 92%

“…ZZCD was effective in interfering with both the anxiety and depressive behaviors.Therefore, it is suggested that chronic restraint stress combined with corticosterone injection is an effective method for constructing anxiety-depression models, and ZZCD can significantly reverse the anxiety-depression state caused by it.According to results of ELISA, ZZCD can exert antidepressant and anxiety effects by reducing the levels of pro-inflammatory factors (IL-1β and TNF-α) in peripheral blood, increasing the levels of anti-inflammatory factors (IL-10) and neurotransmitters (5-HT, DA and GABA), and regulating HPA axis hormones (CRH, ACTH, and CORT). Similar to our results, previous reports have shown changes in these neurotransmitters, pro-inflammatory cytokines and HPA axis hormones in the depression mice [34][35][36]. These results indicate that ZZCD can intervene in depression by regulating the HPA axis and peripheral immunity.…”

supporting

confidence: 92%

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Zhi Zi Chi decoction (Gardeniae fructus and semen Sojae Praeparatum) attenuates anxious depression via modulating microbiota–gut–brain axis in corticosterone combined with chronic restraint stress‐induced mice

Tian,

Wang,

Teng

et al. 2023

CNS Neurosci Ther

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BackgroundThe microbiota–gut–brain axis plays a critical role in neuropsychiatric disorders, particularly anxious depression, and attracts more attention gradually. Zhi Zi Chi decoction (ZZCD) consisting of Gardenia jasminoides J. Ellis and Glycine max (L.) Merr, is a classic formula in clinic and widely applied in anxiety and depression treatment. However, the underlying mechanisms of regulating microbiota–gut–brain axis in the treatment of anxious depression by oral administration of ZZCD remain elusive.Materials and MethodsIn this project, we clarified the origin and preparation methods of the Gardenia jasminoides J. Ellis and Glycine max (L.) Merr and examined the chemical ingredients of ZZCD by liquid chromatograph mass spectrometer. Then, corticosterone combined with chronic restraint stress was applied to establish an anxious depression model. After treated with ZZCD standard decoction, based on enzyme‐linked immunosorbent assay (ELISA), 16S rRNA technology, high‐throughput sequencing, quantitative RT‐PCR and fecal microbiota transplantation (FMT), the multiple associations between nucleus accumbens and intestinal flora in anxious depression mice were determined to clarify the mechanism of ZZCD in the treatment of anxiety and depression disorder.ResultsWe found various substances with antidepressant and antianxiety properties in ZZCD such as rosiridin and oleanolic acid. ZZCD could alleviate depressive and anxiety behaviors in anxious depression mice via regulating the disturbance of gut microbiota. Meanwhile, the bioactive compounds of ZZCD might directly active on neurodevelopment and neuroimmune‐related genes. Furthermore, the secretion of prolactin and estrogen, and interfering with mitogen‐activated protein kinase (MAPK) and tumor necrosis factor (TNF) signaling pathways were mainly involved in the multi‐target therapeutic effects of ZZCD against anxiety and depression.ConclusionsThese findings suggested that ZZCD exerts antidepressant effects pleiotropically through modulating the microbiota‐gut‐brain.

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Section: Discussionsupporting

confidence: 92%

supporting

confidence: 92%

Zhi Zi Chi decoction (Gardeniae fructus and semen Sojae Praeparatum) attenuates anxious depression via modulating microbiota–gut–brain axis in corticosterone combined with chronic restraint stress‐induced mice

Tian,

Wang,

Teng

et al. 2023

CNS Neurosci Ther

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show abstract

“…According to the relevant literature [ 8 , 9 ] and preliminary experiments, the project team used a combination of benzoic acid estrogens and oxytocin to prepare a rat model of PD. After an adaptation period of 3 days, except for the normal group, all rats were injected subcutaneously with a combination of benzoic acid estrogens and oxytocin to establish the rat model of primary dysmenorrhea.…”

Section: Experimental Methodsmentioning

confidence: 99%

Metabolomics study of graphene nuangong acupoint plaster for primary dysmenorrhea

Liu,

Zhang,

et al. 2024

Heliyon

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“…In 2015, Professor Xijun Wang published a monograph on Chinmedomics by Elsevier [131] , and he published six series of monographs in yearly volumes of Research Progress in Chinmedomics by Science Press (2016-2021) [132][133][134][135][136][137] . Chinmedomics has been used to evaluate the efficacy of approximately 20 classical TCM formulas and elucidate their mechanisms, a summary of these is provided in Table 4 [138][139][140][141][142][143][144][145][146][147][148][149][150][151][152][153][154] . We will use YHS and YCHD as examples to introduce the detail of Chinmedomics.…”

Section: Chinmedomics Method: Version 30 Plusmentioning

confidence: 99%

“…Ferulic acid, zizyphusin, cinnamic acid, protocatechuic acid-3-glucoside, and azelaic acid [154] GHB: Guanhuangbo (Phellodendri amurensis Cortex); TCM: Traditional Chinese medicine.…”

Section: Primary Dysmenorrheamentioning

confidence: 99%

Version updating of strategy for drug discovery based on effective constituents of traditional Chinese medicines

Sun

et al. 2023

Acupuncture and Herbal Medicine

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The discovery of effective constituents of traditional Chinese medicine (TCM) is an important approach in new drug development. Several well-known drugs, such as artemisinin, berberine, and taxol have been developed using this approach. However, the efficacy and safety of TCM, two key issues for drug development based on TCM clinical experience, remain unclear worldwide. The discovery of relevant constituents is the most important step for determining efficacy and safety. However, TCM formulas used as clinical drugs address a specific TCM syndrome (Zheng), and the complexity of the formula and vagueness of the syndrome make the identification of the effective constituents related to clinical effectiveness challenging. Over decades, researchers have developed transdisciplinary technologies and research methodologies to identify effective constituents in vivo. In this paper, the history of strategy development for identifying the effective constituents related to the clinical efficacy of TCM is reviewed and summarized. The main approaches include the phytochemical method, which involves the classical systematic separation and screening (extraction, separation, purification, structure identification, and activity test); bioactivity-guided separation; serum pharmacochemistry of TCM in vivo; and Chinmedomics, which connects in vivo constituents with the biomarkers of the relevant TCM syndrome. Chinmedomics is a promising strategy to help elucidate the material requirements for the efficacy of TCM, advance the discovery of lead compounds and innovative drugs, and promote modernization in TCM. http://links.lww.com/AHM/A64

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Quality marker discovery of Danggui Jianzhong decoction for treating primary dysmenorrhoea based on chinmedomics strategy

Cited by 6 publications

References 34 publications

Zhi Zi Chi decoction (Gardeniae fructus and semen Sojae Praeparatum) attenuates anxious depression via modulating microbiota–gut–brain axis in corticosterone combined with chronic restraint stress‐induced mice

Zhi Zi Chi decoction (Gardeniae fructus and semen Sojae Praeparatum) attenuates anxious depression via modulating microbiota–gut–brain axis in corticosterone combined with chronic restraint stress‐induced mice

Metabolomics study of graphene nuangong acupoint plaster for primary dysmenorrhea

Version updating of strategy for drug discovery based on effective constituents of traditional Chinese medicines

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