Nutrient pollution, a growing problem for most European river basins, is a priority challenge in the Danube River Basin, a river that interconnects freshwater with the marine environment. The nutrient content of the Lower Danube waters in a river area where hydro-technical works to improve navigation conditions were carried out, respectively between km 375 and km 175, was evaluated in conection with other water quality parameters and with the hydrological regime. This paper is based on the data obtained during the period 2011-2017 on water samples taken from 10 sampling sections, and the following parameters were investigated: pH, ammonia nitrogen - NH4-N, nitrites - NO2-N, nitrates - NO3-N, total nitrogen - TN, orthophosphates - PO4-P, total phosphorus - TP, Chlorophyll a - Chl �a�, all of which are correlated with water flow - Q. The results showed a significant correlation between the nutrients content, Chl �a�, and water flow, taking into account both the anthropic and climatic pressures on the aquatic ecosystem and the impact of the water body loads on the Black Sea coastal zone.