Quality Improvement with Design of Experiments

Vuchkov, Ivan N.; Boyadjieva, Lidia N.

doi:10.1007/978-94-009-0009-7

Cited by 55 publications

(42 citation statements)

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“…al.·Silvae Genetica (2011) 60-3/4, 155-160 Comparative pollen weight was pollen weight per catkin for each treatment/pollen weight per catkin for the control. 2n pollen rates were evaluated by analysis of variance with the statistical program Orthogonality Experiment Assistant II Version 3.1 and q test or S-N-K test according to Forestry Experimental Design (XU and HUANG, 1995;VUCHKOV and BOYADJIEVA, 2001).…”

Section: N Pollen Inductionmentioning

confidence: 99%

Induction of 2n pollen by colchicine inPopulus×popularisand its triploids breeding

Xue

et al. 2011

Silvae Genetica

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Induction of 2n pollen is a required technique for cultivating polyploid via sexual polyploidy. Orthogonal design or Taguchi Design was applied to select the best treatment process of 2n pollen induction inPopulus×popularisfrom different levels of the meiosis stage of male flower buds, colchicine concentration, times of injection, and interval between injections. Flow cytometry and chromosome counting were used to identify the triploids from the offspring ofP.×euramericana. (Dode) Guinier pollinated with induced pollen ofP.×popularis. The results showed that high 2n pollen rate can be achieved by selecting the flower buds during diakinesis stage in meiosis, and then injecting 0.6% colchicine 4 times with 2 hours interval. The 2n pollen rate reached 62.10% by this process, and two triploids were obtained, which indicates that it is possible for cultivating triploids via 2n pollen induction by colchicine treatment in poplar. Results and protocol related to 2n pollen induction, polyploid identification and effect of 2n pollen in this study might be applicable in polyploidy breeding in sectionAigeirosandTacamahacaof poplar.

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Section: N Pollen Inductionmentioning

confidence: 99%

Induction of 2n pollen by colchicine inPopulus×popularisand its triploids breeding

Xue

et al. 2011

Silvae Genetica

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“…7 After this time span the line sag due to increased thermal heating would exceed the operational limits, as has been calculated by UCTE in the course of its investigations. 8 ETRANS is the coordination body between the Swiss grid companies (and not a TSO itself).…”

Section: :21mentioning

confidence: 96%

“…This stresses the operational control and protection of the networks, including the primary energy supply 7 . o The lack of proper security-related standards and of specific security technologies for information and communication systems in the control and protection of the electricity infrastructure jeopardises the achievement of the required riskrelated goals.…”

Section: Executive Summarymentioning

confidence: 99%

“…It also introduces the risk of malicious activities through the information and communication infrastructure with the goal of disrupting the power supply. 7 o The complexity of the network topology creates the possibility of failures that propagate throughout the system, potentially leading to cascading blackouts. There is also a potential that failures escalate from local problems to broad disturbances, as happened in the most recent blackouts.…”

Section: Executive Summarymentioning

confidence: 99%

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Critical Infrastructures at Risk

Gheorghe¹,

Masera²,

Weijnen³

et al. 2006

Topics in Safety, Risk, Reliability and Quality

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“…62 Moreover, lack of fit was statistically nonsignificant (p=0.0895), revealing that the data were fitting within the employed model. 63 The polynomial equation describing the effect of different factors on the PS was as follows: …”

Section: Preparation Of the Nanostructured Formulationsmentioning

confidence: 99%

Tailored nanostructured platforms for boosting transcorneal permeation: Box–Behnken statistical optimization, comprehensive in vitro, ex vivo and in vivo characterization

Elsayed¹,

Sayed²

2017

IJN

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Ocular drug delivery systems suffer from rapid drainage, intractable corneal permeation and short dosing intervals. Transcorneal drug permeation could increase the drug availability and efficiency in the aqueous humor. The aim of this study was to develop and optimize nanostructured formulations to provide accurate doses, long contact time and enhanced drug permeation. Nanovesicles were designed based on Box–Behnken model and prepared using the thin film hydration technique. The formed nanodispersions were evaluated by measuring the particle size, polydispersity index, zeta potential, entrapment efficiency and gelation temperature. The obtained desirability values were utilized to develop an optimized nanostructured in situ gel and insert. The optimized formulations were imaged by transmission and scanning electron microscopes. In addition, rheological characters, in vitro drug diffusion, ex vivo and in vivo permeation and safety of the optimized formulation were investigated. The optimized insert formulation was found to have a relatively lower viscosity, higher diffusion, ex vivo and in vivo permeation, when compared to the optimized in situ gel. So, the lyophilized nanostructured insert could be considered as a promising carrier and transporter for drugs across the cornea with high biocompatibility and effectiveness.

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Quality Improvement with Design of Experiments

Cited by 55 publications

References 0 publications

Induction of 2n pollen by colchicine inPopulus×popularisand its triploids breeding

Induction of 2n pollen by colchicine inPopulus×popularisand its triploids breeding

Critical Infrastructures at Risk

Tailored nanostructured platforms for boosting transcorneal permeation: Box–Behnken statistical optimization, comprehensive in vitro, ex vivo and in vivo characterization

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Quality Improvement with Design of Experiments

Cited by 55 publications

References 0 publications

Induction of 2n pollen by colchicine inPopulus×popularisand its triploids breeding

Induction of 2n pollen by colchicine inPopulus×popularisand its triploids breeding

Critical Infrastructures at Risk

Tailored nanostructured platforms for boosting transcorneal permeation: Box&ndash;Behnken statistical optimization, comprehensive in vitro, ex vivo and in vivo characterization

Contact Info

Product

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Tailored nanostructured platforms for boosting transcorneal permeation: Box–Behnken statistical optimization, comprehensive in vitro, ex vivo and in vivo characterization