Peripheral neuropathy affects ;5% of the population and diabetes is the most common cause. 1 Diabetic neuropathy often leads to pain, but clinicians do not always address neuropathic pain with their patients. 1,2 Given the effect of painful diabetic neuropathy (PDN) on patients' quality of life, appropriate treatment of this prevalent condition is essential. 1 To increase the delivery of effective management for patients with PDN, the American Academy of Neurology Institute (AANI) published a guideline on the treatment of PDN in 2011, and recently updated this guideline. 1The AANI also provides quality measures for individual physicians and clinicians, as well as treatment teams or practices to implement. The AANI's "Practice guideline update: Oral and topical treatment of painful diabetic polyneuropathy" posed a unique opportunity to simultaneously develop quality measures that could quantify how often guideline statements are implemented in practice while also evaluating potential new quality measures that would directly track patient care and outcomes. 1 Based on a meta-analysis, the practice guideline revealed that the medication classes with the highest efficacy for PDN are gabapentinoids, serotonin norepinephrine reuptake inhibitors, tricyclic antidepressants, and sodium channel blockers. 1 Furthermore, topical, nontraditional, and nonpharmacologic interventions are available. 1 Based on the considerable potential harms of opioids, the guideline recommends against starting opioids, including tramadol and tapentadol, for PDN, and recommends offering the option of a safe taper off opioids for those already taking them. 1 In concert with this guideline, the AANI formed a multidisciplinary work group tasked with identifying and developing process measures whose specifications stemmed from the updated diabetic neuropathy guideline statements as well as potential outcome measures that could apply to all polyneuropathy populations, not limited to diabetic neuropathy. These measures complement the AANI's distal symmetric polyneuropathy quality measurement set, which was released in 2014 and reaffirmed in 2019, and are not meant to be comprehensive measures reflecting all of the important aspects of the care of patients with polyneuropathy. 3