Quality control in manufacturing process by near infrared spectroscopy

Construction of predictive models for gentamicin contents in aqueous solution using specific near infrared spectral regions

“…With the advance in chemometrics and computational technology, useful information can be extracted from the weak signals in NIR spectra [12]. Indeed, it has been successfully used for on-line analysis of monitoring pharmaceutical production and bio-fermentation [13][14][15][16]. However, the NIR method has not been used to analyze a single component and the impure components of structurally similar multi-component drugs in aqueous solution.…”

Infrared-Spectroscopy: A Non-Invasive Tool for Medical Diagnostics and Drug Analysis

“…In industrial fields like pharmaceutics this vibrational spectroscopic technique has become a standard tool for quality control since the 1970s [1][2][3][4][5][6][7]. In the last 40 years data processing and prediction became faster and more precise because of high performance computational systems.…”

Development and Validation of an Analytical Method for Identification of Granulated Nicarbazin by near Infrared Reflectance Spectroscopy

“…In the development of the identification test for nicarbazin raw material, the NIR conformance testing approach was utilised to perform sample qualification. [25][26][27] In conformance testing, a calibration set (library) of NIR spectra are recorded from a representative collection of approved batches. After digital pre-processing, such as second derivatisation to remove baseline offset differences between the spectra, the calibration set is represented as an average spectrum and a standard deviation spectrum.…”