Quality control functions of the Visual Field Reading Center (VFRC) for the Optic Neuritis Treatment Trial (ONTT)

Visual field defects in acute optic neuritis - distribution of different types of defect pattern, assessed with threshold-related supraliminal perimetry, ensuring high spatial resolution

“…This may be due to differences in perimetric methodology and due to changes of the applied classification procedure: the suprathreshold strategy employed in our study may be less sensitive to very subtle visual field loss than the threshold strategy which was employed in the ONTT study [12,20]. In the ONTT study, the VFD was classified as diffuse if visual field tests were not performed due to poor visual acuity, and if the whole 30°field was depressed to a significantly lesser extent on the pattern deviation probability plot than on the total deviation probability plot [12,13]. In our opinion, large scotomas extending over the entire 30°of VF should be classified as central scotomas, in accordance with their position and shape.…”

“…To compare our results with the well-known ONTT study by Keltner et al [12][13][14], we re-classified the VFs of the present study according to the categorization instructions of the ONTT Visual Field Reading Center [12]. To achieve more coherent/comparable data, we categorized all VFs that were classified as altitudinal, arcuate, double arcuate and nasal step defects in the ONTT study to retinal nerve fibre bundle defects.…”

Development and validation of a computerized expert system for evaluation of automated visual fields from the Ischemic Optic Neuropathy Decompression Trial

“…Complete agreement in every category was achieved in only 47.4% of 309 affected eyes. In a masked retest, the agreement on shapes was present for 76.2% of 42 cases [7,18]. The same investigators have recently developed a similar classification methodology for visual fields obtained in the Ocular Hypertension Treatment Study (OHTS).…”

“…Glaucoma trials have utilized a number of approaches for evaluating progression, but the algorithms seldom include classifications based upon the defect type. [3-6] Although the Optic Neuritis Treatment Trial (ONTT) investigators categorized visual field defects, they did not use strict definitions for classification and patterns of field loss were qualitatively rather than quantitatively determined [7]. …”

Stratus OCT Quality Control in Two Multi-Centre Multiple Sclerosis Clinical Trials

“…[1][2][3][4][5][6][7] The Reading Center at the University of California (UC), Davis, has served as both a visual field and an OCT reading centre and has participated in several multi-centre therapeutic clinical trials in multiple sclerosis (MS), glaucoma, and optic neuritis. [8][9][10][11] OCT reading centres are valuable in clinical trials not only to provide quality data assessment, standardise procedures, and certify technicians, but also to implement the procedures necessary to reduce the number of poor (unusable) scans and improve the quality of OCT data.…”