Quality control Fourier transform infrared determination of diazepam in pharmaceuticals

Moros, Javier; Garrigues, Salvador; Guárdia, Miguel de la

doi:10.1016/j.jpba.2006.10.036

Cited by 23 publications

(11 citation statements)

References 12 publications

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“…For the past two decades, the transmission FTIR spectroscopy has undergone significant application for quantitative purposes, several in the pharmaceutical analysis field 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 . As suggested above, a FTIR spectrum can be used for verifying the identity and purity of API and for detecting any spectral interference originating from the excipients.…”

Section: Introductionmentioning

confidence: 99%

Transmission FTIR derivative spectroscopy for estimation of furosemide in raw material and tablet dosage form

Gallignani

Rondon

Ovalles

et al. 2014

Acta Pharmaceutica Sinica B

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A Fourier transform infrared derivative spectroscopy (FTIR-DS) method has been developed for determining furosemide (FUR) in pharmaceutical solid dosage form. The method involves the extraction of FUR from tablets with N,N-dimethylformamide by sonication and direct measurement in liquid phase mode using a reduced path length cell. In general, the spectra were measured in transmission mode and the equipment was configured to collect a spectrum at 4 cm−1 resolution and a 13 s collection time (10 scans co-added). The spectra were collected between 1400 cm−1 and 450 cm−1. Derivative spectroscopy was used for data processing and quantitative measurement using the peak area of the second order spectrum of the major spectral band found at 1165 cm−1 (SO2 stretching of FUR) with baseline correction. The method fulfilled most validation requirements in the 2 mg/mL and 20 mg/mL range, with a 0.9998 coefficient of determination obtained by simple calibration model, and a general coefficient of variation <2%. The mean recovery for the proposed assay method resulted within the (100±3)% over the 80%–120% range of the target concentration. The results agree with a pharmacopoeial method and, therefore, could be considered interchangeable.

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Section: Introductionmentioning

confidence: 99%

Transmission FTIR derivative spectroscopy for estimation of furosemide in raw material and tablet dosage form

Gallignani

Rondon

Ovalles

et al. 2014

Acta Pharmaceutica Sinica B

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“…For the past two decades, Fourier Transform Infrared spectroscopy has undergone significant application in the pharmaceutical analysis field [31,32] due to its main advantages of an easy sample preparation with reduced or no pre-processing steps and the prediction of chemical and physical sample parameters from a single spectrum based on the use of multivariate calibration.…”

Section: Irbesartanmentioning

confidence: 99%

Development of Regression Analysis for Determination of Irbesartan in Pharmaceutical Tablets using Fourier Transform Infrared Spectrophotometry

Ma¹

2017

MACIJ

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A simple, cost-effective, fast and non-destructive analytical method was developed for the quantification of irbesartan in tablets using Fourier Transform Infrared (FT-IR) spectroscopy. The FTIR quantification of irbesartan in tablets was performed using two chemometric approaches, partial least squares (PLS) and principal component regression (PCR) methods. To compare the predictive ability of these models, the standard errors of prediction (SEP) were calculated. SEP error values in the range of 0.941-1.62% for calibration and validation data sets were obtained for the twoprocedures applied. A successful quantification of irbesartan in tablets containing 150 mg active ingredient/tablet was performed using the PLS model, with good recovery. The proposed procedure can be a fast, precise and convenient method of irbesartan quantification in commercial tablets.

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“…Peak area values in the interval between 1672 and 1682 cm −1 , corrected with a two points baseline established between 1850 and 1524 cm −1 , were employed to quantify diazepam in samples using an external calibration line obtained with six standard solutions of diazepam dissolved in chloroform. The method provided linear range from 0.16-2.14 mg g −1 with a LOD of 0.04 mg per tablet [133].…”

Section: Infrared (Ftir) Spectroscopymentioning

confidence: 99%

An Overview on Total Analytical Methods for the Detection of 1,4-Benzodiazepines

Uddin¹,

Victoria²,

Samanidou³

et al. 2014

Pharm Anal Acta

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Quality control Fourier transform infrared determination of diazepam in pharmaceuticals

Cited by 23 publications

References 12 publications

Transmission FTIR derivative spectroscopy for estimation of furosemide in raw material and tablet dosage form

Transmission FTIR derivative spectroscopy for estimation of furosemide in raw material and tablet dosage form

Development of Regression Analysis for Determination of Irbesartan in Pharmaceutical Tablets using Fourier Transform Infrared Spectrophotometry

An Overview on Total Analytical Methods for the Detection of 1,4-Benzodiazepines

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