“…169 In many cases, spectroscopicbased tools such as ultraviolet−visible (UV−vis), near-infrared (NIR), Fourier transform-infrared (FT-IR), and Raman spectroscopy have been successfully used for real time monitoring and process control, 170 including the monitoring of extraction and crystallization processes, the production of solid dosage forms, and the quantitation of active substances and impurities. 168 However, these approaches often lack specificity and sensitivity for several other PAT applications. For this reason, chromatography might be considered to be a useful strategy considering its excellent robustness, specificity, and resolution.…”