Quality-by-design approach for development of sustained-release multiple-unit beads of lamotrigine based on ion-cross-linked composite of pectin and okra mucilage: An in vitro appraisal

Safety study of carboxymethylated Basella alba mucilage: a subchronic oral toxicity evaluation in Wistar albino rats

“…Mucilage was extracted from the plant's stem and fruits by precipitation [11]. The carboxymethylation process is achieved through a sodium hydroxide-chloroacetic acid system in which the -CH2COO--group replaces the hydroxyl group on sugar residue.…”

Tailored Basella Alba Mucilage-Based Bipolymeric Hydrogel Beads for Controlled Release of Diclofenac Sodium

“…Acetone was taken as an equal volume of the filtrate and added to it. The precipitated mucilage was separated and washed thrice with acetone to remove residual water and then dried in a hot air oven at 35 °C, powdered, and stored in a desiccator for further use [10].…”

“…As per the literature, extensive chemical modification of polymers has been done, but very scarce data is available on the chemical modification of mucilage. Chemical modification improves the specific functional properties of polymer by introducing functional groups [9][10][11][12]. Bandopadhyay and Nayak (2023) have reported that thiolation of Fenugreek seed polysaccharide can be used as a mucoadhesive agent [13].…”

Molecularly Imprinted Drug Carrier for Lamotrigine—Design, Synthesis, and Characterization of Physicochemical Parameters

“…Nevertheless, its low aqueous solubility at a level of 0.17 g L −1 may result in the delayed onset of action due to sub-therapeutic plasma drug levels, and may also lead to therapeutic failure [8]. For that purpose, new forms of lamotrigine delivery such as nanoliposomes [9], polymeric nanoparticles [10], multiple-unit beads [11], or co-crystals [12], as well as alternative routes of its administration, such as intrathecal [13], transdermal [14], or nasal [15], have recently become a hot topic of scientific investigations. Recently, the latter administration route has gained particular attention due to the direct delivery of lamotrigine to the brain [15], but it suffers from fast clearance from the nasal cavity due to mucociliary action, susceptibility to enzymes present in the nasal mucosa, low absorption of polar drugs and macromolecules, lower bioavailability in case of cold or allergies interferes, and irritation to the mucosa [16].…”