“…The drawback is that, given the prevalence of disease in most populations, it could take more than 10 years using this method to identify a CT with a high error rate if the threshold for an error is set at SIL. The percentage of diagnoses reclassified as unsatisfactory (UNS), ASC, or worse ranges from 12% to 94% [19][20][21][22][23][24][25][26] (Table 17.6). [15][16][17] Even when defined as an upgrade to atypical squamous cells (ASC) or worse, some have reported a frequency as low as 0.18%.…”