Quality assurance and temporal stability of a 1.5 T MRI scanner for MR-guided Photon and Particle Therapy

Dorsch, S.; Paul, Katharina; Beyer, Cedric; Karger, Christian P.; Jäkel, Oliver; Debus, Jürgen; Klüter, Sebastian

doi:10.1016/j.zemedi.2023.04.004

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…First partially-enclosed prototype devices for patient rotation have already been investigated in small scale to test feasibility and imaging capabilities (5)(6)(7)(8)(9). While imaging in particle therapy today usually is performed with x-ray-based systems, also the use of magnetic resonance imaging (MRI) has become increasingly important (10)(11)(12). In photon radiotherapy, integrated hybrid-systems combining MRI and linear accelerators are already wellestablished (13)(14)(15)(16)(17)(18), and rst concepts for combining particle therapy with MRI have been evaluated (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Compliance of volunteers in a fully-enclosed patient rotation system for MR-guided radiation therapy – a prospective study

Beyer,

Paul,

Dorsch

et al. 2023

Preprint

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Background Particle therapy makes a noteworthy contribution in the treatment of tumor diseases. In order to be able to irradiate from different angles, usually expensive, complex and large gantries are used. Instead rotating the beam via a gantry, the patient itself might be rotated. Here we present tolerance and compliance of volunteers for a fully-enclosed patient rotation system in a clinical magnetic resonance (MR)-scanner for potential use in MR-guided radiotherapy, conducted within a prospective evaluation study. Method A patient rotation system was used to simulate and perform magnetic resonance imaging (MRI)-examinations with 50 volunteers without an oncological question. For 20 participants, the MR-examination within the bore was simulated by introducing realistic MRI noise, whereas 30 participants received an examination with image acquisition. Initially, body parameters and claustrophobia were assessed. The subjects were then rotated to different angles for simulation (0°, 45°, 90°, 180°) and imaging (0°, 70°, 90°, 110°). At each angle, anxiety and motion sickness were assessed using a 6-item State-Trait-Anxiety-Inventory (STAI-6) and a modified Motion Sickness Assessment Questionnaire (MSAQ). In addition, general areas of discomfort were evaluated. Results Out of 50 subjects, three (6%) subjects terminated the study prematurely. One subject dropped out during simulation due to nausea while rotating to 45°. During imaging, further two subjects dropped out due to shoulder pain from positioning at 90° and 110°, respectively. The average result for claustrophobia (0 = no claustrophobia to 4 = extreme claustrophobia) was none to light claustrophobia (average score: simulation 0.64 ± 0.33, imaging 0.51 ± 0.39). The mean anxiety scores (0% = no anxiety to 100% = maximal anxiety) were 11.04% (simulation) and 15.82% (imaging). Mean motion sickness scores (0% = no motion sickness to 100% = maximal motion sickness) of 3.5% (simulation) and 6.76% (imaging) were obtained across all participants. Conclusion Our study proves the feasibility of horizontal rotation in a fully-enclosed rotation system within an MR-scanner. Anxiety scores were low and motion sickness was only a minor influence. Both anxiety and motion sickness showed no angular dependency. Further optimizations with regard to immobilization in the rotation device may increase subject comfort.

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Section: Introductionmentioning

confidence: 99%

Compliance of volunteers in a fully-enclosed patient rotation system for MR-guided radiation therapy – a prospective study

Beyer,

Paul,

Dorsch

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Compliance of volunteers in a fully-enclosed patient rotation system for MR-guided radiation therapy: a prospective study

Beyer,

Paul,

Dorsch

et al. 2024

Radiat Oncol

View full text Add to dashboard Cite

Background Particle therapy makes a noteworthy contribution in the treatment of tumor diseases. In order to be able to irradiate from different angles, usually expensive, complex and large gantries are used. Instead rotating the beam via a gantry, the patient itself might be rotated. Here we present tolerance and compliance of volunteers for a fully-enclosed patient rotation system in a clinical magnetic resonance (MR)-scanner for potential use in MR-guided radiotherapy, conducted within a prospective evaluation study. Methods A patient rotation system was used to simulate and perform magnetic resonance imaging (MRI)-examinations with 50 volunteers without an oncological question. For 20 participants, the MR-examination within the bore was simulated by introducing realistic MRI noise, whereas 30 participants received an examination with image acquisition. Initially, body parameters and claustrophobia were assessed. The subjects were then rotated to different angles for simulation (0°, 45°, 90°, 180°) and imaging (0°, 70°, 90°, 110°). At each angle, anxiety and motion sickness were assessed using a 6-item State-Trait-Anxiety-Inventory (STAI-6) and a modified Motion Sickness Assessment Questionnaire (MSAQ). In addition, general areas of discomfort were evaluated. Results Out of 50 subjects, three (6%) subjects terminated the study prematurely. One subject dropped out during simulation due to nausea while rotating to 45°. During imaging, further two subjects dropped out due to shoulder pain from positioning at 90° and 110°, respectively. The average result for claustrophobia (0 = no claustrophobia to 4 = extreme claustrophobia) was none to light claustrophobia (average score: simulation 0.64 ± 0.33, imaging 0.51 ± 0.39). The mean anxiety scores (0% = no anxiety to 100% = maximal anxiety) were 11.04% (simulation) and 15.82% (imaging). Mean motion sickness scores (0% = no motion sickness to 100% = maximal motion sickness) of 3.5% (simulation) and 6.76% (imaging) were obtained across all participants. Conclusion Our study proves the feasibility of horizontal rotation in a fully-enclosed rotation system within an MR-scanner. Anxiety scores were low and motion sickness was only a minor influence. Both anxiety and motion sickness showed no angular dependency. Further optimizations with regard to immobilization in the rotation device may increase subject comfort.

show abstract

Quality assurance and temporal stability of a 1.5 T MRI scanner for MR-guided Photon and Particle Therapy

Cited by 2 publications

References 41 publications

Compliance of volunteers in a fully-enclosed patient rotation system for MR-guided radiation therapy – a prospective study

Compliance of volunteers in a fully-enclosed patient rotation system for MR-guided radiation therapy – a prospective study

Compliance of volunteers in a fully-enclosed patient rotation system for MR-guided radiation therapy: a prospective study

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