Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design

Mirković, Dušica; Ibrić, Svetlana; Antunović, Marko

doi:10.2298/vsp1304374m

Cited by 2 publications

(2 citation statements)

References 15 publications

(7 reference statements)

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“…The spectrum of diseases in which the TPN application is indicated is very wide, so it can be said that they are used in almost all areas of medicine. TPN admixtures known as the "All-in-One", are systems in which all the macronutrients (amino acids, glucose, lipids) and micronutrients (electrolytes, vitamins, oligoelements) are mixed and stored in the ethyl-vinyl-acetate (EVA) bag 1,2 .…”

Section: Introductionmentioning

confidence: 99%

Investigation of short-term stability of parenteral nutrition nanoemulsions prepared under laboratory conditions

Mirković

Ibrić

2020

VOJNOSANIT PREGL

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Background/Aim. The application of nanoemulsions (NE) in parenteral nutrition represents a very important advancement that marked the medicine and pharmacy of the twentieth century. Over the years, the technology of the production of NE and total parenteral nutrition (TPN) nanoemulsions or admixtures has undergone constant improvement. Representing the continuation of the previous research, this paper deals with nanoemulsions in a concentration of 20% that were prepared under laboratory conditions. The main emphasis was put on the possibility of detecting the potential presence of large droplets or agglomerates of droplets that could cause fatal effects. In addition, the quality assessment of the TPN admixture containing these nanoemulsions was performed. These results were compared with the results obtained from the TPN admixture prepared from the industrial emulsion (Lipofundin MCT/LCT 20% ®). Methods. During the 30-day period of monitoring nanoemulsion physical-chemical characteristics, the volume diameters that define the width of the lipid droplet size distribution were determined using the laser diffraction method. In addition, TPN physical and chemical characteristics were monitored for 72 hours and included: measurements of the mean droplet diameter, the volume diameter, distribution of the droplet size, ie. polydispersity index (PDI), ζ-potential, and pH values. Results. Obtained results were in accordance with the literature data related to the quality of parenteral nanoemulsions (values of volume diameters ranged between 50 and 490 nm). TPN admixtures remained stable during the testing period, even in cases when TPN admixtures containing either a newly formed or an industrial nanoemulsion were tested. Conclusion. Characteristics of investigated nanoemulsions do not significantly alter under the ambient temperature storage. If the preparation principles and the component mixing order are followed, TPN admixture possessing satisfactory physical and chemical quality and stability can be obtained.

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Section: Introductionmentioning

confidence: 99%

Investigation of short-term stability of parenteral nutrition nanoemulsions prepared under laboratory conditions

Mirković

Ibrić

2020

VOJNOSANIT PREGL

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“…Advantages of admixing all nutrients in one container provide more convenience for administration, efficient for pharmacy personnel and storage, cheaper, lessen microbe contamination, usage of medical equipment, and monitoring time by nurse [10]. The total parenteral nutrition (3-in-1) that contains lipid tends to cause physical instability with the presence of electrolyte, especially polyvalent cation [11].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Sodium Chloride 0.9% Infusion Solution and Ringer’s Solution on Particle Size of Intravenous Lipid Emulsion (Intralipid 20%)

Bangun

Nil²,

Arianto³

2016

Asian J Pharm Clin Res

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Objective: To study the effect of admixing intralipid (IL) with sodium chloride (NaCl) 0.9% infusion solution or Ringer's solution (RS) on physical stability of IL.Methods: Incompatibility test was done in two methods of admixture, i.e. in one container (1:1) and through three-way stopcock (1:2). They were observed for 24 hrs on its emulsion type, pH, microscopic observation of lipid globules, and globules size. Results:The results of admixing IL and electrolyte solution (NaCl or RS) in one container and through three-way stopcock showed no changes in color and emulsion type (O/W). Physical stability evaluation results of IL and NaCl admixture in one container and through three-way stopcock showed that the pH value was 5.1 and 5.2, respectively, and microscopic observation of lipid globules and its size showed coalescence on 24 hrs with size 625.16 nm (one container) and stable during 24 hrs (three-way stopcock). Physical stability evaluation results of IL and RS admixture in one container and through three-way stopcock showed that the pH value was 4.9 and 5.1, respectively, and microscopic observation of lipid globules and its size showed coalescence on 12 hrs with size 572.81 nm (one container) and flocculation on 24 hrs with size 558.12 nm (three-way stopcock). Conclusion:Admixing electrolyte solution (NaCl or RS) and IL in one container and through three-way stopcock causes the larger globule size of IL.

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Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design

Abstract: Within a 72-hour testing period there was no significant increase in droplet size, i.e. the studied admixtures remained stable considering droplet size median as the criterion of stability.

Cited by 2 publications

References 15 publications

Investigation of short-term stability of parenteral nutrition nanoemulsions prepared under laboratory conditions

Investigation of short-term stability of parenteral nutrition nanoemulsions prepared under laboratory conditions

The Effect of Sodium Chloride 0.9% Infusion Solution and Ringer’s Solution on Particle Size of Intravenous Lipid Emulsion (Intralipid 20%)

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