Quality Assessment ofPolygonum cuspidatumandPolygonum multiflorumby1H NMR Metabolite Fingerprinting and Profiling Analysis

Frédérich, Michel; Wauters, Jean-Noël; Tits, Monique; Jason, Charlotte; Tullio, Pascal De; Heyden, Yvan Van der; Fan, Guorong; Angenot, Luc

doi:10.1055/s-0030-1250132

Cited by 30 publications

(20 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…P. multiflorum is especially well known for its reputed anti-ageing benefits and is believed to be longevity promoting when consumed daily for an extended period (Bensky et al, 2004). P. cuspidatum elaborates trans-resveratrol, (a stilbene) and emodin, physicon, chrysophanol, and polydatin (hyroxyanthraquinones) while P. multiflorum produces 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside emodine and physicon (Frederich et al, 2011). In the present study, P.…”

Section: Discussionsupporting

confidence: 49%

Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells

Steele

Truong

Govindaraghavan

et al. 2013

Neurochemistry International

View full text Add to dashboard Cite

Munch, G. (2013). Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells. Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry, 62 (5), 522-529. Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells AbstractAge is the leading risk factor for many of the most prevalent and devastating diseases including neurodegenerative diseases. A number of herbal medicines have been used for centuries to ameliorate the deleterious effects of ageing-related diseases and increase longevity. Oxidative stress is believed to play a role in normal ageing as well as in neurodegenerative processes. Since many of the constituents of herbal extracts are known antioxidants, it is believed that restoring oxidative balance may be one of the underlying mechanisms by which medicinal herbs can protect against ageing and cognitive decline. Based on the premise that astrocytes are key modulators in the progression of oxidative stress associated neurodegenerative diseases, 13 herbal extracts purported to possess anti-ageing properties were tested for their ability to protect U373 human astrocytes from hydrogen peroxide induced cell death. To determine the contribution of antioxidant activity to the cytoprotective ability of extracts, total phenol content and radical scavenging capacities of extracts were examined. Polygonum multiflorum, amongst others, was identified as possessing potent antioxidant and cytoprotective properties. Not surprisingly, total phenol content of extracts was strongly correlated with antioxidant capacity. Interestingly, when total phenol content and radical scavenging capacities of extracts were compared to the cytoprotective properties of extracts, only moderately strong correlations were observed. This finding suggests the involvement of multiple protective mechanisms in the beneficial effects of these medicinal herbs. AbstractAge is the leading risk factor for many of the most prevalent and devastating diseases including neurodegenerative diseases. A number of herbal medicines have been used for centuries to ameliorate the deleterious effects of ageing-related diseases and increase longevity. Oxidative stress is believed to play a role in normal ageing as well as in neurodegenerative processes. Since many of the constituents of herbal extracts are known antioxidants, it is believed that restoring oxidative balance may be one of the underlying mechanisms by which medicinal herbs can protect against ageing and cognitive decline. Based on the premise that astrocytes are key modulators in the progression of oxidative stress associated neurodegenerative diseases, 13 herbal extracts purported to possess antiageing properties were tested for their ability to protect U373 human astrocytes from hydrogen peroxide induced cell death. To determine the contribution of antioxidant activity to the cytoprotective ab...

show abstract

Section: Discussionsupporting

confidence: 49%

Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells

Steele

Truong

Govindaraghavan

et al. 2013

Neurochemistry International

View full text Add to dashboard Cite

show abstract

“…The chemical composition of these two species is similar, the major compounds being stilbenes and anthraquinone derivatives (Frédérich et al 2011). They can be differentiated by identification of their stilbene derivatives; however, some confusion exists within the pharmaceutical market regarding P. multiflorum and P. cuspidatum (Frédérich et al 2011), so we cannot exclude that in our case, P. multiflorum had been used instead of P. cuspidatum.…”

Section: Discussionmentioning

confidence: 90%

Hepatotoxicity of green tea: an update

2015

View full text Add to dashboard Cite

Green tea (GT), obtained from the leaves of Camellia sinensis (L.) Kuntze (Fam. Theaceae), is largely used for its potential health benefits such as reduction in risk of cardiovascular diseases and weight loss. Nevertheless, it is suspected to induce liver damage. Present work reviews the hepatic adverse reactions associated with GT-based herbal supplements, published by the end of 2008 to March 2015. A systematic research was carried out on PubMed, MedlinePlus, Scopus and Google Scholar databases, without any language restriction. Moreover, some accessible databases on pharmacovigilance or phytovigilance were consulted. The causality assessment was performed using the CIOMS/RUCAM score. Nineteen cases of hepatotoxicity related to the consumption of herbal products containing GT were identified. The hepatic reactions involved mostly women (16/19); the kind of liver damage was generally classified as hepatocellular (16/19). The causality assessment between consumption of herbal preparation and hepatic reaction resulted as probable in eight cases and as possible in eleven cases. In seven cases, patients used preparations containing only GT, while twelve reactions involved patients who took multicomponent preparations (MC). The reactions induced by GT had a generally long latency (179.1 ± 58.95 days), and the outcome was always resolution, with recovery time of 64.6 ± 17.78 days. On the contrary, liver injury associated with MC had a shorter latency (44.7 ± 13.85 days) and was more serious in four cases that required liver transplantation and, when resolution occurred, the recovery time was longer (118.9 ± 38.79). MC preparations contained numerous other components, many of which are suspected to induce liver damage, so it is difficult to ascribe the toxicity to one specific component, e.g., GT. Present data confirm a certain safety concern with GT, even if the number of hepatic reactions reported is low considering the great extent of use of this supplement. The mechanism of GT hepatotoxicity remains unclear, but factors related to the patient are becoming predominant. A major safety concern exists when GT is associated with other ingredients that can interact between them and with GT, enhancing the risk of liver damage. Patients should be discouraged from using herbal or dietary supplements containing complex mixtures and should be encouraged to use herbal and dietary supplement possibly under supervision of healthcare professionals.

show abstract

“…More particularly in the pharmaceutical field, metabolomic techniques and applications find scope from drug discovery to clinical development of new medicines. This includes target identification and validation, elucidation of the mechanisms of action of drugs, lead identification [9,10], identification of drug efficacy or pathology biomarkers [11][12][13], toxicological analysis by identification of safety biomarkers [14][15][16] but also quality control, particularly of medicinal plants [17,18] and bioactive drug discovery from natural sources [19] .…”

Section: Introductionmentioning

confidence: 99%