Quality assessment of <i>Penthorum chinense</i> Pursh through multicomponent qualification and fingerprint, chemometric, and antihepatocarcinoma analyses

Sun, Zong-Liang; Zhang, Yuzhen; Zhang, Feng; Zhang, Jiawei; Zheng, Guolin; Tan, Ling; Wang, Chong‐Zhi; Zhou, Ling; Zhang, Qi‐Hui; Yuan, Chun‐Su

doi:10.1039/c8fo00754c

Cited by 22 publications

(14 citation statements)

References 23 publications

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“…Moreover, pinocembrin activates glycogen synthase kinase 3β by acting on SIRT3, thereby enhancing the degradation of Smad protein [10]. Pinocembrin-7- O -[3ʺ- O -galloyl-4ʺ,6ʺ-hexahydroxydiphenoyl]-β-glucose is the derivative of pinocembrin, and it significantly contributes to the hepatoprotective effects of the latter [59]. This finding indicates that pinocembrin can be used as a drug candidate for the treatment of liver diseases.…”

Section: Pharmacological Effects Of Pinocembrinmentioning

confidence: 99%

Advances in Biosynthesis, Pharmacology, and Pharmacokinetics of Pinocembrin, a Promising Natural Small-Molecule Drug

et al. 2019

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Pinocembrin is one of the most abundant flavonoids in propolis, and it may also be widely found in a variety of plants. In addition to natural extraction, pinocembrin can be obtained by biosynthesis. Biosynthesis efficiency can be improved by a metabolic engineering strategy and a two-phase pH fermentation strategy. Pinocembrin poses an interest for its remarkable pharmacological activities, such as neuroprotection, anti-oxidation, and anti-inflammation. Studies have shown that pinocembrin works excellently in treating ischemic stroke. Pinocembrin can reduce nerve damage in the ischemic area and reduce mitochondrial dysfunction and the degree of oxidative stress. Given its significant efficacy in cerebral ischemia, pinocembrin has been approved by China Food and Drug Administration (CFDA) as a new treatment drug for ischemic stroke and is currently in progress in phase II clinical trials. Research has shown that pinocembrin can be absorbed rapidly in the body and easily cross the blood–brain barrier. In addition, the absorption/elimination process of pinocembrin occurs rapidly and shows no serious accumulation in the body. Pinocembrin has also been found to play a role in Parkinson’s disease, Alzheimer’s disease, and specific solid tumors, but its mechanisms of action require in-depth studies. In this review, we summarized the latest 10 years of studies on the biosynthesis, pharmacological activities, and pharmacokinetics of pinocembrin, focusing on its effects on certain diseases, aiming to explore its targets, explaining possible mechanisms of action, and finding potential therapeutic applications.

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Section: Pharmacological Effects Of Pinocembrinmentioning

confidence: 99%

Advances in Biosynthesis, Pharmacology, and Pharmacokinetics of Pinocembrin, a Promising Natural Small-Molecule Drug

et al. 2019

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“…Autophagy plays an important role in the pathogenesis of alcohol hepatitis, although it has not been reported in the treatment of alcohol hepatitis with PCP [ 101 ].…”

Section: Discussionmentioning

confidence: 99%

An Overview of the Mechanism of Penthorum chinense Pursh on Alcoholic Fatty Liver

Zhao

Liao

Zhou

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Alcohol liver disease (ALD) caused by excessive alcohol consumption is a progressive disease, and alcohol fatty liver disease is the primary stage. Currently, there is no approved drug for its treatment. Abstinence is the best way to heal, but patients’ compliance is poor. Unlike other chronic diseases, alcohol fatty liver disease is not caused by nutritional deficiencies; it is caused by the molecular action of ingested alcohol and its metabolites. More and more studies have shown the potential of Penthorum chinense Pursh (PCP) in the clinical use of alcohol fatty liver treatment. The purpose of this paper is to reveal from the essence of PCP treatment of alcohol liver mechanism mainly by the ethanol dehydrogenase (ADH) and microsomal ethanol oxidation system-dependent cytochrome P4502E1 (CYP2E1) to exert antilipogenesis, antioxidant, anti-inflammatory, antiapoptotic, and autophagy effects, with special emphasis on its mechanisms related to SIRT1/AMPK, KEAP-1/Nrf2, and TLR4/NF-κB. Overall, data from the literature shows that PCP appears to be a promising hepatoprotective traditional Chinese medicine (TCM).

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“…Flavonoids are common active components in herbs, which show a variety of biological activities, including not only antioxidation but also bacteriostatic effects [32] . Previous studies reported that quercetin and pinocembrin-7-O-β-glucoside [33][34][35] are abundant in PCP. Both compounds showed antibacterial activity [36,37] .…”

Section: Discussionmentioning

confidence: 99%

A comparison of the biological activities of ethyl acetate fractions from the stems and leaves of Penthorum chinense Pursh

Jiang¹,

Ding²,

Liu³

et al. 2020

Front. Agr. Sci. Eng.

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Penthorum chinense Pursh (PCP) is a popular traditional medicinal plant in China, widely used for the treatment of a variety of liver diseases. Although it has been long recognized that the main active elements of PCP are contained in ethyl acetate fraction (EAF), little is known so far in terms of the relative effectiveness of EAF derived from the stems versus leaves of this plant. In the current study, we prepared EAF by reflux extraction and sequential extraction from the stems (SEAF) and leaves (LEAF) of PCP and tested their hepatoprotective efficacies. The extract rates and flavonoid contents of LEAF were higher than those of SEAF. EAFs ( > 50 μg$mL -1 ) prevented lipid accumulation in cells and protected against lipotoxicity injury when the concentration exceeded 25 μg$mL -1 . More than 95% free radicals released by 2,2-diphenyl-1-picrylhydrazyl (DPPH) were eliminated by 25 μg$mL -1 SEAF and 50 μg$mL -1 LEAF, respectively. Further, EAFs (25 μg$mL -1 ) also showed protective antioxidant effects, with the activity of LEAF being significantly higher than that of SEAF. EAFs (10 mg$mL -1 ) also showed similar unspecific bacteriostatic activity. In comparison with SEAF, LEAF contained more flavonoids and had a higher anti-oxidation capability and for these reasons we suggest it should be better for clinical use.

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Quality assessment of Penthorum chinense Pursh through multicomponent qualification and fingerprint, chemometric, and antihepatocarcinoma analyses

Cited by 22 publications

References 23 publications

Advances in Biosynthesis, Pharmacology, and Pharmacokinetics of Pinocembrin, a Promising Natural Small-Molecule Drug

Advances in Biosynthesis, Pharmacology, and Pharmacokinetics of Pinocembrin, a Promising Natural Small-Molecule Drug

An Overview of the Mechanism of Penthorum chinense Pursh on Alcoholic Fatty Liver

A comparison of the biological activities of ethyl acetate fractions from the stems and leaves of Penthorum chinense Pursh

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