Quality analysis of different marketed brands of paracetamol available in Bangladesh

Kar, Auditi; Amin, Mohammad Nurul; Hossain, Mohammad Salim; Mukul, Emdadul Hasan; Rashed, Saif Uddin; Ibrahim, Ibrahim

doi:10.3329/icpj.v4i9.24473

Cited by 7 publications

(15 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Friability Test. This method is also called as the attritionresistance method and testing the ability of a tablet to resist mechanical fracture during handling and manufacturing [16,17].…”

Section: Biomed Research Internationalmentioning

confidence: 99%

Consumers’ Perception of Generic Medicines and Evaluation of In Vitro Quality Control Parameters of Locally Manufactured Paracetamol Tablets in Asmara, Eritrea: A Cross-Sectional Study

Idris

Hassan

Hassen

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Generic medicines are clinically equivalent and can be used interchangeably for their intended use. Globally, the usage of generic medicines is highly recommended because of their affordability and accessibility. However, consumers hold a negative perception and attitude of using generic medicine as they consider it poor and having inferior quality compared to branded medicines. This study was conducted to assess the consumers’ general view of generic medicines and in vitro evaluation of a locally produced generic medicine, paracetamol. An analytical and cross-sectional study was conducted in three selected hospitals, and in vitro quality control evaluation was done in National Drug Quality Control Laboratory between October 26 and November 21, 2017, in Asmara, Eritrea. A systematic random sampling design was employed, and the data was collected using a questionnaire and a check-list for recording the quality control parameters of paracetamol tablets. A total of 403 respondents were included in the study. The majority of the study participants were females (61.8%). Generally, about half (49.1%) of the respondents choose locally manufactured paracetamol over the imported ones. More than half (68.5%) of the respondents did not believe expensive medicines are of better quality. The main reason consumers prefer the local paracetamol (Azemol) tablet to the imported one was due to their good experience (62.1%). About three-fourths (78.1%) of the consumers also believed that medicines manufactured abroad confer higher quality. At the multivariate level, having educational backgrounds such as elementary ( AOR = 4.19 , 95% CI: 1.251, 14.035) and junior ( AOR = 2.4 , 95% CI: 1.146, 5.028) was associated with preferability to local paracetamol as a pain killer over the brand ones. The in vitro test of the local paracetamol met the standard specification for the identification test, weight variation test, pharmacopeial test, friability test, disintegration test, and dissolution test. In conclusion, the majority of the consumers considered local paracetamol as having an inferior quality when compared with brand paracetamol. However, the reality revealed that the local paracetamol was of the same quality as the brand ones. To facilitate widespread use of generic medicines, healthcare professionals should educate consumers on the advantages of these medicines.

show abstract

“…Friability Test. This method is also called as the attritionresistance method and testing the ability of a tablet to resist mechanical fracture during handling and manufacturing [16,17].…”

Section: Biomed Research Internationalmentioning

confidence: 99%

Consumers’ Perception of Generic Medicines and Evaluation of In Vitro Quality Control Parameters of Locally Manufactured Paracetamol Tablets in Asmara, Eritrea: A Cross-Sectional Study

Idris

Hassan

Hassen

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Various studies conducted in Malaysia, Palestine, Pakistan, Bangladesh, and India have investigated brands of paracetamol and fulfilled the requirements on USP for disintegration time. 3,7,[19][20][21] Dissolution was another parameter directly related to the absorption and bioavailability of the drug. Drugs with poor dissolution profiles will not be sufficiently available in the body to produce the desired therapeutic outcome.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…9 Paracetamol is being the most frequently counterfeited medication; studies have been conducted on its quality assessment in different countries. 2,7,[9][10][11][12][13] Usually, a single generic drug is manufactured by different companies under different brand names. In many countries, the drug is also manufactured by small scale manufacturers which may be widely distributed or locally consumed.…”

Section: Introductionmentioning

confidence: 99%

“… 5 , 6 Patients may lack the specialized knowledge to detect whether the product they are using is of good quality or not. 7 Counterfeited medications have can mislead especially if they are coped to make it look like the original product so that the patients are unlikely suspicious. According to WHO, (2017) the prevalence of fake medicines was higher in developing countries with week regulations, enforcement, and scarcity of supply of essential medicines, unregulated market, and unaffordable prices.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In-vitro Evaluations of Quality Control Parameters of Paracetamol Tablets Marketed in Gondar City, Northwest Ethiopia

Abebe¹,

Beressa²,

Yimer³

2020

DHPS

View full text Add to dashboard Cite

Background The aim of this research was to evaluate quality control parameters of available brands of paracetamol tablets in Gondar city since standard quality parameters are essential for a better quality of the product. The different brands of paracetamol tablets were obtained from local pharmacies in Gondar town and the University of Gondar (UOG) hospital pharmacies. Methods Five brands of paracetamol, from each, 102 tablets were collected from private pharmacies, government health centers, and UOG pharmacies. The popular brands in the city, Panadol, Para-denk, Paramol, Paracetamol (EPHARM), and Cadimol, conventional tablets of 500 mg strength were chosen and the tablets were assessed for different quality parameters: weight variation, hardness, friability, disintegration, dissolution, and drug content (assay) using compendial methods. The tablets were evaluated to check if they comply with the specifications of USP (United States Pharmacopeia). Results From the results, it was observed that all the brands of paracetamol have passed the tests and met the specifications of USP. Results of weight variation, hardness, friability, and disintegration time ranged from 0.46 to 1.11%, 117.0 to 174.70 N, 0.07 to 0.63%, and 01 to 08 minutes for all the tablets, respectively. The dissolution profiles of all the brands are within the acceptable label claim. The assay results showed that the drug content of the paracetamol brands ranged from 95.04% to 106.81%. The dissolution rate was significantly different (p < 0.05) as compared to code 1 with all brands tested at 30 minutes. The disintegration time of different brands was also significantly different from the comparator (code 1) except code 2. Conclusion Based on the finding from this study, there were no significant deviations from pharmacopeia standards and specifications. The brands studied were safe enough and could be used to achieve the desired therapeutic effect.

show abstract

Comparative in-vitro analysis of different brands of paracetamol tablets available in Nepal

Thakuri¹,

Yadav²,

Chhetri³

2016

J Coast Life Med

View full text Add to dashboard Cite

Quality analysis of different marketed brands of paracetamol available in Bangladesh

Cited by 7 publications

References 19 publications

Consumers’ Perception of Generic Medicines and Evaluation of In Vitro Quality Control Parameters of Locally Manufactured Paracetamol Tablets in Asmara, Eritrea: A Cross-Sectional Study

Consumers’ Perception of Generic Medicines and Evaluation of In Vitro Quality Control Parameters of Locally Manufactured Paracetamol Tablets in Asmara, Eritrea: A Cross-Sectional Study

In-vitro Evaluations of Quality Control Parameters of Paracetamol Tablets Marketed in Gondar City, Northwest Ethiopia

Comparative in-vitro analysis of different brands of paracetamol tablets available in Nepal

Contact Info

Product

Resources

About