Qualitative β-hCG urine assays may be misleading in the presence of molar pregnancy: a case report

Davison, Chris M.; Kaplan, Richard M; Wenig, T. Linda N.; Burmeister, David D.

doi:10.1016/j.jemermed.2004.02.009

Cited by 15 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Partial mole have triploid karyotype of maternal and paternal origin and presence of fetal/embryonic tissue. [3][4][5] Hydatidiform mole changes to invasive mole in 7-17% and metastasis occurs in 4% of cases. The invasive mole and choriocarcinoma comprises the term malignant trophoblastic disease.…”

Section: Discussionmentioning

confidence: 99%

“…1 in 5 women need chemotherapy after a molar pregnancy. 3 Chemotherapy is given if hcg level begins to rise/is detectable after a 4-6 months/if choriocarcnoma is found in tissue sample.…”

Section: Discussionmentioning

confidence: 99%

“…However large levels of serum hcg can cause oversaturation of the assay system, resulting in false negative result in urine pregnancy test. 3 However the gynecologist must be aware of this clinical entity and this can be resolved by further evaluation of serum quantification of β hcg by DPC immulite assay to detect serum β hcg and urine sample with 1:10 dilution for pregnancy test. 3,4…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molar pregnancy with false negative urine pregnancy test, the hook effect

Gupta¹

2021

IJOGR

View full text Add to dashboard Cite

Molar pregnancy is characterized by high level of serum β hcg which can be usually detected by urine pregnancy test as a first screening test. Urine pregnancy test is also used as the first screening test for patients of reproductive age presenting with gynecological problem in order to exclude pregnancy. Rarely large amounts of β human chorionic gonadotrophin (hcg) may cause a false negative result due to over saturation of the assay system, known as, 'the hook effect'. This can result clinical dilemma in the diagnosis and delay in the management. When there is clinical features of molar pregnancy, the knowledge of "The Hook Effect" will help at arriving at the diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

“…1 in 5 women need chemotherapy after a molar pregnancy. 3 Chemotherapy is given if hcg level begins to rise/is detectable after a 4-6 months/if choriocarcnoma is found in tissue sample.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Molar pregnancy with false negative urine pregnancy test, the hook effect

Gupta¹

2021

IJOGR

View full text Add to dashboard Cite

show abstract

“…Interestingly, sandwich chromatographic immuno‐assays, such as qualitative β‐hCG assays, may produce false‐negative results in the presence of excessively high antigen concentrations. This phenomenon is known as the “high‐dose hook effect.” This effect may result in a false‐negative qualitative β‐hCG result 8 , 9 . Those cases with false‐negative serum assay results require dilution of the samples and retesting if sonography shows evidence of molar pregnancy 8 , 10 …”

Section: Discussionmentioning

confidence: 99%

“…Because of earlier diagnoses of molar pregnancies, the commonly reported clinical findings of molar pregnancy such as large theca lutein cysts and hyperthyroidism are rare 8 , 9 . Several studies have reported that sonography correctly showed molar pregnancy before evacuation in less than 60% of cases 12 , 13 .…”

Section: Discussionmentioning

confidence: 99%

Atypical Presentations of Molar Pregnancy

Mohamed

Al-Hendy

Ghamande

et al. 2016

J of Ultrasound Medicine

View full text Add to dashboard Cite

In modern practice , the diagnosis of molar pregnancy is made at an early gestational age. The opportunity to diagnose gestational trophoblastic disease (GTD) using sonography alone occurs less frequently. The classic appearance of a "snowstorm" in the endometrial cavity and bilateral theca lutein cysts still applies to the diagnosis of second-trimester GTD. The diagnosis of first-trimester GTD requires increased clinical suspicion. If the sonographic appearance of the pregnancy is atypical, GTD should be included in the differential diagnosis. Additional nonimaging criteria such as serial quantitative β-human chorionic gonadotropin levels, pathologic examination, and p57 (cyclin-dependent kinase inhibitor 1C protein) immunostaining can accurately confirm the diagnosis of GTD.

show abstract

Current awareness in prenatal diagnosis

2004

Prenatal Diagnosis

View full text Add to dashboard Cite

In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of prenatal diagnosis. Each bibliography is divided into 17 sections: 1 Books, Reviews & Symposia; 2 General Interest; 3 Normal Fetal Development; 4 Gametogenesis and Pre‐implantation Diagnosis; 5 First Trimester Diagnosis; 6 Second Trimester Diagnosis; 7 Fetal Diagnosis by Ultrasound and Other Imaging; 8 Maternal Screening; 9 Screening for Carriers of Genetic Abnormality; 10 Technological Developments; 11 Confined Placental Mosaicism and Uniparental Disomy; 12 Molecular Cytogenetics; 13 Fetal Cells in Maternal Circulation; 14 Fetal Therapy; 15 Psychosocial Aspects; 16 Epidemiology and Environmental Factors; 17 Developmental Pathology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

show abstract

Qualitative β-hCG urine assays may be misleading in the presence of molar pregnancy: a case report

Cited by 15 publications

References 15 publications

Molar pregnancy with false negative urine pregnancy test, the hook effect

Molar pregnancy with false negative urine pregnancy test, the hook effect

Atypical Presentations of Molar Pregnancy

Current awareness in prenatal diagnosis

Contact Info

Product

Resources

About