“…7,8 Reported barriers include lack of confidence in the use of AAPs, and healthcare professionals believing that AAPs should be used only with certain types of patients. 9,10 Another possible reason for the 312 paucity of AAP use is that primary healthcare professionals are not convinced of the applicability of AAPs to their patients, 11,12 since the recommendation of AAP effectiveness is based on the outcome of randomised controlled trials (RCTs) 13 and not from "real-life" populations where most patients would not qualify for enrolment in a classic RCT. 14 Moreover, the frequent clinical care and monitoring of patients in RCTs is not typical of 'real-world' clinical situations.…”