Qualitative/quantitative determination of sulfamethazine in swine tissue by gas chromatographic/electron impact mass spectrometry using a stable isotope labeled internal standard

Fragmentation pathways of sulphonamides under electrospray tandem mass spectrometric conditions

“…With the aid of literature references23–26 and of Mass Frontier™ (Thermo Finnigan), an AI software package that deals with the interpretation and prediction of mass spectra, structures can be assigned to some of the main fragment ions observed for the sulphonamides. In the case of the amino‐sulphonamides, e.g.…”

“… Structures proposed for the fragment ions of the amino‐sulphonamides according to literature references23–26 and Mass Frontier. …”

“…The common fragment ions produced by the known sulphonamide drugs have been reported. In certain cases, studies have been carried out for detailed identification of the structures of the fragment ions produced 23–27. However, in the majority of the publications, only the most bond facile cleavages are reported, and therefore structures are proposed mainly for the fragment ions that do not involve rearrangements.…”

Gas liquid chromatography chemical ionization selected ion monitoring assay for glycerol formal in animal tissues

“…Combined gas-liquid chromatography (GLC)-mass spectrometry with selected ion monitoring is an often-employed approach for quantifying compounds of biological interest at the parts per billion level (Carlin et al, 1980;Garland and Powell, 1981;Suhre et al, 1981). No characteristic ions of high intensity were produced from glycerol formal by using electron impact ionization, but chemical ionization (isobutane reagent gas) mass spectrometry appeared to offer a potentially suitable method for detection and quantification of glycerol formal.…”

“…packed column with no isomer separation can be used with confidence to determine total glycerol formal residue levels. Use of a mass spectrometric based detection assay system offers the opportunity for utilizing a heavy isotope labeled analogue of the compound of interest as the internal standard (Carlin et al, 1980; Suhre et al, 1981). Glycerol formal-d2 was prepared from glycerol and perdeuterioparaformaidehyde.…”