Qualitative Platelet Abnormalities in Idiopathic Thrombocytopenic Purpura

Clancy, R. L.; Jenkins, Elizabeth A.; Firkin, Barry G.

doi:10.1056/nejm197203232861202

Cited by 113 publications

(40 citation statements)

References 11 publications

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“…This would seem to indicate that immunoglobulin administration also decreases the adherent and/or circulating anti platelet antibodies. In other words, after immuno globulin treatment the immunological thrombocytopathy described in some ITP patients by Clancy et al [21 ] and Stuart et al [22] would disappear.…”

Section: Discussionmentioning

confidence: 91%

Successful Treatment of a Steroid-Resistant Form of Idiopathic Thrombocytopenic Purpura in Pregnancy with High Doses of Intravenous Immunoglobulins

et al. 1987

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Idiopathic thrombocytopenic purpura (ITP) during pregnancy may cause serious bleeding in the mother and fetus. Therapy with high-dose intravenous immunoglobulins has caused an immediate and predictable rise in platelet count in both adults and children with chronic or acute ITP. We report our experience in managing a woman near term in pregnancy. The patient demonstrated a rapid increase in platelet count, delivered without excessive bleeding and had a normal child with normal platelet count. Intravenous immunoglobulins may offer a new and safe way to control maternal and fetal platelet counts during pregnancy, delivery and neonatal period.

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Section: Discussionmentioning

confidence: 91%

Successful Treatment of a Steroid-Resistant Form of Idiopathic Thrombocytopenic Purpura in Pregnancy with High Doses of Intravenous Immunoglobulins

et al. 1987

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“…Evidence for such a mechanism is supported by Zahavi and Marder's study (34) of a patient with an undifferentiated connective tissue disease. Additional evidence is offered in reports of impaired platelet aggregation in some patients with idiopathic thrombocytopenic purpura (35). Presumed antiplatelet antibodies in patients with SLE have been reported (36-38).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of abnormal platelet aggregation in systemic lupus erythematosus

Dorsch

Meyerhoff

1982

Arthritis & Rheumatism

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Platelet aggregation was measured in 14 patients with systemic lupus erythematosus (SLE) and 13 normal controls. Ten SLE patients (group I) showed decreased responsiveness to collagen, while aggregation was normal in 4 (group 11). Group I patients also responded poorly to epinephrine. Platelets from SLE patients did not differ from controls in the production of malondialdehyde in response to N-ethylmaleimide, suggesting intact prostaglandin synthetic pathways. However, a significant decrease (P < 0.005) in platelet levels of the dense granule constituent, serotonin, was noted in group I SLE patients. Treatment of SLE platelet-rich plasma with deoxyribonuclease (DNase) resulted in enhancement of collagen-induced aggregation in 4 group I SLE patients, but not in 1 group I1 or 8 normal individuals. These results suggest that defective aggregation in SLE platelets may be partially related to a storage pool deficiency state. However, the ability to restore aggregation to collagen by digestion of platelet-rich plasma with DNase indicates that the defect is reversible and that it is perhaps mediated by plasma or platelet-associated DNA.In 1974, Regan et a1 (1) described abnormalities in the aggregation of platelets obtained from 12 of 21

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“…18]. Generally, the anti coagulants are directed against prothrombin activator complexes, factors VIII and IX [9,13,14,17,18], and very rarely against factors XI [4][5][6][7][8][9][10][11][12] and XII [6,7].…”

Section: Discussionmentioning

confidence: 99%

Circulating Anticoagulant against Factor XI and Thrombocytopenia with Platelet Aggregation Inhibition in Systemic Lupus Erythematosus

Leone¹,

Accorrà²,

Boni³

1977

Acta Haematol

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In a patient with systemic lupus erythematosus, anticoagulant activity directed against factor XI was found together with thrombocytopenia. In the serum globulin fraction, antiplatelet antibodies and an activity-inhibiting platelet aggregation could also be found. A possible correlation between the inhibition of platelet aggregation and the anticoagulant activity directed against factor XI is discussed

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Qualitative Platelet Abnormalities in Idiopathic Thrombocytopenic Purpura

Cited by 113 publications

References 11 publications

Successful Treatment of a Steroid-Resistant Form of Idiopathic Thrombocytopenic Purpura in Pregnancy with High Doses of Intravenous Immunoglobulins

Successful Treatment of a Steroid-Resistant Form of Idiopathic Thrombocytopenic Purpura in Pregnancy with High Doses of Intravenous Immunoglobulins

Mechanisms of abnormal platelet aggregation in systemic lupus erythematosus

Circulating Anticoagulant against Factor XI and Thrombocytopenia with Platelet Aggregation Inhibition in Systemic Lupus Erythematosus

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