Qualitative comparison of active compounds between red and green Mariposa Christia Vespertillonis leaves extracts

Osman, Mohamed Syazwan; Ghani, Zaidi Ab; Ismail, Normah; Razak, Noor ‘Aina Abdul; Jaapar, Jefri; Ariff, Mohd Azahar Mohd

doi:10.1063/1.5002476

Cited by 7 publications

(3 citation statements)

References 10 publications

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“…The process took about 60 minutes. The resulting oil was then submitted for qualitative analysis using Liquid Chromatography-Mass Spectrometry (LCMS) to identify the active compounds (24).…”

Section: Extraction Methodsmentioning

confidence: 99%

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A Review on Pharmacological Properties of Christia vespertilionis

Ibrahim¹,

Amom²,

Dasiman³

et al. 2022

MJMHS

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Commonly referred to as ‘daun rerama’, Christia vespertilionis has increased in popularity in traditional and modern medicine. This review aims to report the relevance of this plant in terms of its traditional uses, pharmacological actions, phytoconstituents, extractions methods, and identify the research gaps and future potentials. The review is conducted as per PRISMA guidelines; a database search was conducted in Web of Science, Science Direct, Scopus and Google Scholar from 1996 to 2021. Results show that to date, phytochemicals such as alkaloids, flavonoids, quinones, and others have been identified, corresponding to its range of pharmacological activities that include anti-cancer, anti-malaria, and antioxidant. There have also been claims of antidiabetic activity but not supported by enough scientific evidence. Study on molecular and gene expression was still lacking. There is a good future in the research of this plant with many potential aspects to be investigated.

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Section: Extraction Methodsmentioning

confidence: 99%

“…A study discovered the compound linoleate in the extract of C. vespertilionis (red leave) after analysis using LC-MS (24). Linoleate is a polyunsaturated omega-6 fatty acid ester that has anti-inflammatory, acne-reducing, and moisture-retaining effects when applied topically to the skin.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

A Review on Pharmacological Properties of Christia vespertilionis

Ibrahim¹,

Amom²,

Dasiman³

et al. 2022

MJMHS

View full text Add to dashboard Cite

show abstract

“…Based on recent reports, the leaves of C. vespertilionis were shown to exhibit anti-malarial, anti-inflammatory, anti-proliferative and anti-cancer effects against various cancer types [8,15,17,18]. Aside from that, the plant was also reported to contain a variety of phytocompounds including polyphenols, alkaloids, and terpenoids which may be constituents that are responsible for the antioxidant and anti-cancer activities [8,15,19].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Christia vespertilionis Root and Leaf Extracts and Fractions against Breast Cancer Cell Lines

et al. 2020

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Christia vespertilionis, commonly known as ‘Daun Rerama’, has recently garnered attention from numerous sources in Malaysia as an alternative treatment. Its herbal decoction was believed to show anti-inflammatory and anti-cancer effects. The present study investigated the cytotoxicity of the extract of root and leaf of C. vespertilionis. The plant parts were successively extracted using the solvent maceration method. The most active extract was further fractionated to afford F1–F8. The cytotoxic effects were determined using MTT assay against human breast carcinoma cell lines (MCF-7 and MDA-MB-231). The total phenolic content (TPC) of the extracts were determined. The antioxidant properties of the extract were also studied using DPPH and β-carotene bleaching assays. The ethyl acetate root extract demonstrated selective cytotoxicity especially against MDA-MB-231 with the highest TPC and antioxidant properties compared to others (p < 0.05). The TPC and antioxidant results suggest the contribution of phenolic compounds toward its antioxidant strength leading to significant cytotoxicity. F3 showed potent cytotoxic effects while F4 showed better antioxidative strength compared to others (p < 0.05). Qualitative phytochemical screening of the most active fraction, F3, suggested the presence of flavonoids, coumarins and quinones to be responsible toward the cytotoxicity. The study showed the root extracts of C. vespertilionis to possess notable anti-breast cancer effects.

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