Qualitative and quantitative use of micropollutants as source and process indicators. A review

Warner, W. Keith; Licha, Tobias; Nödler, Karsten

doi:10.1016/j.scitotenv.2019.05.385

Cited by 58 publications

(32 citation statements)

References 207 publications

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“…The pharmaceutical contaminants observed at the 75% of RSQA sites without NPDES-permitted discharges, however, confirm previous conclusions that WWTP outfalls are not the only important pathways of pharmaceutical contaminants to urban/suburban streams [1,7,88,89]. Other potential urban-gradient sources of pharmaceuticals to streams include aging sewer infrastructure [90,91], combined (sanitary/stormwater) sewer overflows [92][93][94][95][96], private septic and on-site waste-handling systems [97][98][99], gray-water systems [100][101][102], green space and golf course wastewater reuse [103], and animal waste runoff [104][105][106].…”

Section: Pharmaceutical Mixtures Were Common In All Regionssupporting

confidence: 84%

Multi-region assessment of pharmaceutical exposures and predicted effects in USA wadeable urban-gradient streams

et al. 2020

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Human-use pharmaceuticals in urban streams link aquatic-ecosystem health to human health. Pharmaceutical mixtures have been widely reported in larger streams due to historical emphasis on wastewater-treatment plant (WWTP) sources, with limited investigation of pharmaceutical exposures and potential effects in smaller headwater streams. In 2014-2017, the United States Geological Survey measured 111 pharmaceutical compounds in 308 headwater streams (261 urban-gradient sites sampled 3-5 times, 47 putative lowimpact sites sampled once) in 4 regions across the US. Simultaneous exposures to multiple pharmaceutical compounds (pharmaceutical mixtures) were observed in 91% of streams (248 urban-gradient, 32 low-impact), with 88 analytes detected across all sites and cumulative maximum concentrations up to 36,142 ng/L per site. Cumulative detections and concentrations correlated to urban land use and presence/absence of permitted WWTP discharges, but pharmaceutical mixtures also were common in the 75% of sampled streams without WWTP. Cumulative exposure-activity ratios (EAR) indicated widespread transient exposures with high probability of molecular effects to vertebrates. Considering the potential individual and interactive effects of the detected pharmaceuticals and the recognized analytical underestimation of the pharmaceutical-contaminant (unassessed parent compounds, metabolites, degradates) space, these results demonstrate a nationwide environmental concern and the need for watershed-scale mitigation of in-stream pharmaceutical contamination.

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Section: Pharmaceutical Mixtures Were Common In All Regionssupporting

confidence: 84%

Multi-region assessment of pharmaceutical exposures and predicted effects in USA wadeable urban-gradient streams

et al. 2020

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“…Water micropollutants are known as contaminants found in small concentrations (trace levels of ng/L to μg/L) in the aquatic environment [1]. They include various types of natural or synthetic substances such as drugs (antidiabetic medicines, anaesthetics, analgesics, anti-inflammatories, antihypertensives, antivirals, fungicides, antibiotics, diuretics, anxiolytics, anticonvulsants, antidepressants, antihistamines, lipid-regulators) [2][3][4], personal care products (fragrances, disinfectants, UV filters, repellents) [5,6], hormones (estrogens, testosterone, progesterone, mestranol) [7][8][9], chemicals (plasticizers, surfactants, dyes) used in different industrial areas (food, textile, paint, polymers) [10,11], pesticides (insecticides, herbicides, fungicides) [12,13] etc.…”

Section: Introductionmentioning

confidence: 99%

An Eco-Friendly Solution for the Efficient Elimination of Pentoxifylline from Water: An Operational Performance Investigation

Gavrilă¹,

Simion²,

Grigoraș³

et al. 2020

Rev. Chim.

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In recent years, more and more pollutants (including pharmaceuticals, personal care products, pesticides, herbicides, hormones, chemicals) are detected in the aquatic environment. Even if they are encountered in very low concentrations, the toxicological data reveal that they represent a major risk both for the water living organisms and for human beings. Moreover, an important resistance to the classical methods applied at wastewater treatment plants characterizes them. Aeration, coagulation, flocculation, sedimentation, filtration, adsorption, oxidation, activated sludge treatments are often either insufficient or completely ineffective. To overcome these drawbacks, many researches were dedicated to the development of new effective techniques for the removal of these water pollutants. Advanced oxidation methods are widely reported as being of the most efficient ones. In this article, we investigate the utility of the photocatalysis as a sustainable alternative for the enhanced elimination of an emergent water micropollutant. We evaluate here the impact of several parameters (catalyst type and concentration, contaminant concentration, radiant flux intensity) on the process efficiency. The targeted compound involved in the experiments was the pentoxifylline (a drug used in the treatment of diseases such as diabetic neuropathy, osteoradionecrosis or hepatic fibrogenesis). The registered pollutant removal rate under the selected reaction conditions (photocatalyst type: ZnO; photocatalyst concentration: 0.5 g/L; incident light flux: 9.52 mW/cm2; natural pH) reached values near to 100 % providing new insights on the viability and the efficiency of the evaluated methodology.

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“…It should be pointed out that one of the main particularities of this ratio is that the proportion of SMX and TMP used in human medication is similar worldwide (if we except several European countries, in which the SMX/TMP ratios are found to be proportional with the use of TMP alone), allowing its use at a global scale. Hence, unlike other chemical markers that require in -depth knowledge of the catchment studied (McCance et al, 2018;Warner et al, 2019), the SMX/TMP ratio is suitable for the evaluation of the main origin of wastewaters by comparison to the theoretical value calculated here.…”

Section: Potential Of Smx/tmp Ratio To Be Used As a Markermentioning

confidence: 95%

“…Several markers have been developed in order to easily obtain information about wastewater contamination of environmental compartments (Tran et al, 2019b;Warner et al, 2019). Among the targeted emerging contaminants, the use of the most resilient ones as markers has been assessed, i.e.…”

Section: Introductionmentioning

confidence: 99%

Sulfamethoxazole/Trimethoprim ratio as a new marker in raw wastewaters: A critical review

Thiebault

2020

Science of The Total Environment

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Global Trimethoprim (TMP) and Sulfamethoxazole (SMX) occurrences in raw wastewaters were systematically collected from the literature (n=140 articles) in order to assess the relevance of using the SMX/TMP ratio as a marker of the main origin of wastewaters. These two antibiotics were selected due to their frequent use in association (i.e. co-trimoxazole) in a 5:1 ratio (SMX:TMP) for medication purposes, generating a unique opportunity to globally evaluate the validity of this ratio based on concentration values. Several parameters (e.g. sorption, biodegradation) may affect the theoretical SMX/TMP ratio. However, the collected data highlighted the good agreement between the theoretical ratio and the experimental one, especially in wastewater treatment plant influents and hospital effluents. Only livestock effluents displayed a very high SMX/TMP ratio, indicative of the very significant use of sulfonamide alone in this industry. Conversely, several countries displayed low SMX/TMP ratio values, highlighting local features in the human pharmacopoeia. This review provides new insights in order to develop an easy to handle and sound marker of wastewater origins (i.e. human/livestock), beyond atypical local customs.

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Qualitative and quantitative use of micropollutants as source and process indicators. A review

Cited by 58 publications

References 207 publications

Multi-region assessment of pharmaceutical exposures and predicted effects in USA wadeable urban-gradient streams

Multi-region assessment of pharmaceutical exposures and predicted effects in USA wadeable urban-gradient streams

An Eco-Friendly Solution for the Efficient Elimination of Pentoxifylline from Water: An Operational Performance Investigation

Sulfamethoxazole/Trimethoprim ratio as a new marker in raw wastewaters: A critical review

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