Qualitative and Quantitative Analysis of Bioactive Principles in Zingiberis Rhizoma by Means of High Performance Liquid Chromatography and Gas Liquid Chromatography. On the Evaluation of Zinglberis Rhizoma and Chemical Change of Constituents during Zingiberis Rhizoma Processing

Yoshikawa, Masayuki; Hatakeyama, Shoko; Chatani, Nobuyasu; Nishino, Yukie; Yamahara, Johji

doi:10.1248/yakushi1947.113.4_307

Cited by 43 publications

(18 citation statements)

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“…high-performance liquid chromatographic (Yoshikawa et al, 1994;He et al, 1998;Nakazawa and Ohsawa, 2002) and gas-chromatographic-mass-spectrometric (GC-MS) methods (Harvey, 1981;Chen et al, 1986) have been developed for the analysis of [6]-gingerol and [6]-shogaol in plant extract, but neither of the MS methods was developed for the quantitative analysis in biological matrices. The analytical methods were primarily used for identification of the mass spectra of the gingerol standards (Harvey, 1981) and for the identification of the pungent compounds in ginger.…”

Section: Severalmentioning

confidence: 99%

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

Kubra

Rao

2012

Critical Reviews in Food Science and Nutrition

156

118

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Ginger rhizome (Zingiber officinale Roscoe) is widely cultivated as a spice for its aromatic and pungent components. The essential oil and oleoresins from ginger are valuable products responsible for the characteristic flavor and pungency. Both are used in several food products such as soft beverages and also in many types of pharmaceutical formulations. More than 100 compounds have been reported from ginger, some of which are isolated and characterized, others are tentatively identified by GC-MS and / or LC-MS. [6]-Gingerol, the major gingerol in ginger rhizomes, has been found to possess many interesting pharmacological and physiological activities, such as anti-inflammatory, analgesic, and cardiotonic effects. Ginger is considered as "generally recognized as safe" (GRAS) by Food and Drug Administration (FDA), USA. Due to all these properties, ginger has gained considerable attention in developed countries in recent years, especially for its use in the treatment of inflammatory conditions. The present review is a persuasive presentation of the current information on processing, chemistry, biological activities, and medicinal uses of ginger. Further studies are required for the validation of the beneficial uses. Formulation for novel products and new usages may emerge in the years to come, based on the revealed results of various studies.

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Section: Severalmentioning

confidence: 99%

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

Kubra

Rao

2012

Critical Reviews in Food Science and Nutrition

156

118

View full text Add to dashboard Cite

show abstract

“…Numerous constituents have been reported to be present in Z. officinale, including volatile essential oil, tannins, flavonoids, sulphonatated compounds and pungent principles like zingerone, gingerols and shogaols (Yoshikawa et al, 1993;Ali et al, 2008). In general, flavonoids and tannins (Galvez et al l993;Miranda et al, 1993), and recently zingerone , have been reported to present antidiarrhoeal activity, which has been credited to inhibition of intestinal motility and secretion (Di Carlo et al, 1993) and antimicrobial action (Lutterodt et al, 1999).…”

Section: Zingiber Officinale Roscoe Zingiberaceae (Gengibre)mentioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Medicinal plants have been used in traditional medicine for several thousand years all over the world. In this sense, information from Brazilian ethnic groups on folk medicine have contributed to the discovery of pharmacological activities from various plant-derived agents potentially leading to the innovative drugs. The Caatinga (semi-arid) vegetation is a highly threatened biome, covering a vast area in northeastern Brazil and has suffered from strong human influence for many decades. Many plants species found in the Caatinga have been widely used in folk medicine and for commercial manufacturing of phytotherapeutic products. Thus, the present review aims to disseminate to the scientific community some known species of medicinal plants found in the Caatinga that have been studied and analyzed in pharmacological scientific assays. Among the species that stood out for their local importance and multiplicity of uses were: Amburana cearensisand Zingiber officinalis L. (gengibre). The present study shows that several herbal constituents from Caatinga plants, whose pharmacological actions have been well characterized, may be relevant candidates for future and innovative therapeutic development.

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“…One study has documented the ability of several extracts of ginger to protect against ameliorating carbon tetrachloride and acetaminophen-induced acute hepatotoxicity (Yemitan and Izegbu 2006). Despite the identification of more than 400 compounds, [6]-shogaol, [6]-gingerol, [8]-gingerol, and [10]-gingerol have been identified as major biologically active components responsible for antiemetic, antipyretic, anti-cancer, and anti-inflammatory effects (Yoshikawa et al 1993;Nakazawa and Ohsawa 2002). Several studies have reported that [6]-gingerol had various pharmacological functions, such as anti-apoptotic (Kim et al 2007), anti-oxidant, anti-inflammatory properties (Phan et al 2005) via the inhibition of cytokine formation, and antimelanogenesis to suppress melanin synthesis through the activation of the PI3K signaling pathway (Huang et al 2011).…”

Section: Introductionmentioning

confidence: 99%

[10]-Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells

Ryu

Chung

2014

In Vitro Cell.Dev.Biol.-Animal

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The present study was designed to investigate the molecular mechanisms of [10]-gingerol activity against HCT116 human colon cancer cells. [10]-Gingerol inhibited the proliferation of HCT116 cells by 50% at a concentration of 30 μM, and this inhibition was dose-dependent accompanied by the morphological changes indicative of apoptosis. Furthermore, flow cytometric analysis showed that [10]-gingerol increased DNA in the sub-G1 phase of the cell cycle, and the extent of apoptosis was confirmed by Annexin V and PI double staining. Analysis of the mechanism of these events indicated that [10]-gingerol-treated cells exhibited an increased ratio of Bax/Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner, which are hallmarks of apoptosis. Moreover, [10]-gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, c-Jun N-terminal kinase (JNK), p38 MAPK (p38), and extracellular signal-regulated kinase (ERK). This is the first report to demonstrate the cytotoxic effect of [10]-gingerol on human colon cancer cells, as well as the first to describe its possible chemotherapeutic potentials.

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Qualitative and Quantitative Analysis of Bioactive Principles in Zingiberis Rhizoma by Means of High Performance Liquid Chromatography and Gas Liquid Chromatography. On the Evaluation of Zinglberis Rhizoma and Chemical Change of Constituents during Zingiberis Rhizoma Processing

Cited by 43 publications

References 0 publications

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

[10]-Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells

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