Qualitative and quantitative analysis of polycyclic polyprenylated acylphloroglucinols from Garcinia species using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry

Zhou, Yan; Lee, Stephanie J.; Choi, Franky Fung Kei; Xu, Gang; Liu, Xin; Song, Jing‐Zheng; Li, Songlin; Qiao, Chun‐Feng; Xu, Hong‐Xi

doi:10.1016/j.aca.2010.08.010

Cited by 22 publications

(11 citation statements)

References 33 publications

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“…Members of the genus Garcinia from the family Guitefferae are considered as a rich and valuable source of bioactive compounds [41–44]. In a study by Pereira et al .…”

Section: Resultsmentioning

confidence: 99%

In Vitro Anti-Listerial Activities of Crude n-Hexane and Aqueous Extracts of Garcinia kola (heckel) Seeds

Penduka

Okoh

2011

IJMS

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We assessed the anti-Listerial activities of crude n-hexane and aqueous extracts of Garcinia kola seeds against a panel of 42 Listeria isolates previously isolated from wastewater effluents in the Eastern Cape Province of South Africa and belonging to Listeria monocytogenes, Listeria grayi and Listeria ivanovii species. The n-hexane fraction was active against 45% of the test bacteria with zones of inhibition ranging between 8–17 mm, while the aqueous fraction was active against 29% with zones of inhibition ranging between 8–11 mm. The minimum inhibitory concentrations (MIC) were within the ranges of 0.079–0.625 mg/mL for the n-hexane extract and 10 to >10 mg/mL for the aqueous extract. The rate of kill experiment carried out for the n-hexane extract only, revealed complete elimination of the initial bacterial population for L. grayi (LAL 15) at 3× and 4× MIC after 90 and 60 min; L. monocytogenes (LAL 8) at 3× and 4× MIC after 60 and 15 min; L. ivanovii (LEL 18) at 3× and 4× MIC after 120 and 15 min; L. ivanovii (LEL 30) at 2, 3 and 4× MIC values after 105, 90 and 15 min exposure time respectively. The rate of kill activities were time- and concentration-dependant and the extract proved to be bactericidal as it achieved a more than 3log10 decrease in viable cell counts after 2 h exposure time for all of the four test organisms at 3× and 4× MIC values. The results therefore show the potential presence of anti-Listerial compounds in Garcinia kola seeds that can be exploited in effective anti-Listerial chemotherapy.

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“…Members of the genus Garcinia from the family Guitefferae are considered as a rich and valuable source of bioactive compounds [41–44]. In a study by Pereira et al .…”

Section: Resultsmentioning

confidence: 99%

In Vitro Anti-Listerial Activities of Crude n-Hexane and Aqueous Extracts of Garcinia kola (heckel) Seeds

Penduka

Okoh

2011

IJMS

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“…Twenty-eight cynandione A derivatives including 4 known and 24 novel components from the roots of the two species were identified. Zhou et al thoroughly investigated polyprenylated acylphloroglucinols (PPAPs) in the plant of Garcinia species [146,147]. PPAPs featuring a highly oxygenated and densely substituted bicyclo[3.3.1]nonane-2,4,9-trione core decorated with prenyl or geranyl side chains, have remarkable pharmacological effects.…”

Section: Miscellaneous Compoundsmentioning

confidence: 99%

“…PID is a product ion scan mode in which the mass spectrometer switches back and forth continuously between MS and MS/MS survey conditions with low and high collision energies until a given product ion is detected. In another study, fragmentation of the deprotonated molecules was conducted by in-source dissociation techniques based on cone voltage fragmentation and then multiple mass spectrometry (MS/MS) using ramping collision energy were applied to further break down the resulting product ions [146]. Two new PPAPs isomers present in minor amount in the extracts of G. oblongifolia were identified.…”

Section: Miscellaneous Compoundsmentioning

confidence: 99%

Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry

Guo

Chen

et al. 2013

Journal of Pharmaceutical and Biomedical Analysis

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161

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“…Quadrupole time‐of‐flight mass spectrometry (Q‐TOF/MS) allows the generation of mass information with higher accuracy and precision for the identification of known or unknown compounds. This technique can be used to produce candidate empirical formulae which, at the mass accuracy of less than 5 ppm, significantly reduce the number of possible structures of putative compounds []. Mass spectrometry Elevated Energy (MS E ) can provide parallel alternating scans for acquisition at either low collision energy to obtain precursor ion information, or ramping of high collision energy to obtain full‐scan accurate mass fragment, precursor ion, and neutral loss information [].…”

Section: Introductionmentioning

confidence: 99%

Ultra performance liquid chromatography coupled with electrospray and atmospheric pressure chemical ionization (ESCi)‐quadrupole time‐of‐flight mass spectrometry with novel mass spectrometry^{Elevated Energy} (MS^E) data collection technique: Determination and pharmacokinetics, tissue distribution and biliary excretion study of ergone in rat

Zhao

Cheng

Wei

et al. 2012

J of Separation Science

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Ergosta-4,6,8(14),22-tetraen-3-one (ergone) has been proved to have novel antitumor effects on HepG2 cells. The aim of this study was to investigate the pharmacokinetics, tissue distribution, and biliary excretion of ergone in rats following a single oral administration (5, 10, and 20 mg/kg). The levels of ergone in plasma, tissues, and bile were measured by ultra performance liquid chromatography coupled with electrospray and atmospheric pressure chemical ionization (ESCi)-quadrupole time-of-flight mass spectrometry with novel mass spectrometry(Elevated Energy) (MS(E)) data collection technique method. The results show ergone was distributed and eliminated from rat plasma and in non-linear pharmacokinetics from a dose range of 5-20 mg/kg. The ergone was found to distribute widely in the internal organs, with tissue concentrations in order of lungs, spleen, liver, intestine, kidneys, heart, stomach, parorchis, teasticles, and brain. At 12 h after dosing, the tissue concentrations in the organs were markedly decreased. The lungs, spleen, and liver were the dominant organs with high tissue concentrations that might be the primary sites for metabolism and elimination of ergone. Total recoveries of ergone within 24 h in bile were 34.14%.

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Qualitative and quantitative analysis of polycyclic polyprenylated acylphloroglucinols from Garcinia species using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry

Cited by 22 publications

References 33 publications

In Vitro Anti-Listerial Activities of Crude n-Hexane and Aqueous Extracts of Garcinia kola (heckel) Seeds

In Vitro Anti-Listerial Activities of Crude n-Hexane and Aqueous Extracts of Garcinia kola (heckel) Seeds

Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography–mass spectrometry

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