BACKGROUND Social media in scientific research offers a unique digital observatory of human behaviours and hence great opportunities to conduct research at large scale, answering complex sociodemographic questions. We focus on the identification and assessment of biases in social-media-administered surveys. OBJECTIVE This study aims to shed light on population, self-selection, and behavioural biases, empirically comparing the consistency between self-reported information collected traditionally versus social-media-administered questionnaires, including demographic and psychometric attributes. METHODS We engaged a demographically representative cohort of young adults in Italy (approximately 4,000 participants) in taking a traditionally administered online survey and then, after one year, we invited them to use our ad hoc Facebook application (988 accepted) where they filled in part of the initial survey. We assess the statistically significant differences indicating population, self-selection, and behavioural biases due to the different context in which the questionnaire is administered.